What fires prometheus? The link between inflammation and regeneration following chronic liver injury.

[1]  M. Vukcevic,et al.  Plasma and platelet serotonin levels in patients with liver cirrhosis. , 2007, World journal of gastroenterology.

[2]  N. Tygstrup,et al.  Thy-1 is expressed in hepatic myofibroblasts and not oval cells in stem cell-mediated liver regeneration. , 2007, The American journal of pathology.

[3]  T. Vanhaecke,et al.  Differentiation of neonatal rat epithelial cells from biliary origin into immature hepatic cells by sequential exposure to hepatogenic cytokines and growth factors reflecting liver development. , 2007, Toxicology in vitro : an international journal published in association with BIBRA.

[4]  E. Kuipers,et al.  Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus–specific immune response , 2007, Hepatology.

[5]  M. Kremer,et al.  Impaired liver regeneration and increased oval cell numbers following T cell–mediated hepatitis , 2007, Hepatology.

[6]  N. Tygstrup,et al.  Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell–mediated liver regeneration , 2007, Hepatology.

[7]  P. Doherty,et al.  Virus-Specific CD8+ T Cells in the Liver: Armed and Ready to Kill1 , 2007, The Journal of Immunology.

[8]  W. Alexander,et al.  Opposing roles of gp130‐mediated STAT‐3 and ERK‐1/2 signaling in liver progenitor cell migration and proliferation , 2007, Hepatology.

[9]  W. Parks,et al.  Transforming growth factor‐beta differentially regulates oval cell and hepatocyte proliferation , 2007, Hepatology.

[10]  J. Olynyk,et al.  Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet. , 2007, The international journal of biochemistry & cell biology.

[11]  J. Olynyk,et al.  Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice. , 2007, Journal of hepatology.

[12]  J. O’Shea,et al.  T(H)-17 differentiation: of mice and men. , 2007, Nature Immunology.

[13]  P. Doherty,et al.  Virus-Specific CD 8 T Cells in the Liver : Armed and Ready to Kill 1 , 2007 .

[14]  J. Olynyk,et al.  Evaluation of the "Cellscreen" system for proliferation studies on liver progenitor cells. , 2006, European journal of cell biology.

[15]  B. Petersen,et al.  Oval cell response in 2-acetylaminofluorene/partial hepatectomy rat is attenuated by short interfering RNA targeted to stromal cell-derived factor-1. , 2006, The American journal of pathology.

[16]  H. Jaeschke,et al.  Role of neutrophils in acute inflammatory liver injury , 2006, Liver international : official journal of the International Association for the Study of the Liver.

[17]  J. Sicklick,et al.  Interleukin-15 increases hepatic regenerative activity. , 2006, Journal of hepatology.

[18]  P. Charneau,et al.  Plasticity of Hepatic Cell Differentiation: Bipotential Adult Mouse Liver Clonal Cell Lines Competent to Differentiate In Vitro and In Vivo , 2006, Stem Cells.

[19]  J. Olynyk,et al.  Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo , 2006, Hepatology.

[20]  W. Jochum,et al.  Platelet-Derived Serotonin Mediates Liver Regeneration , 2006, Science.

[21]  Yu-Tseung Liu,et al.  Activation of anti-hepatitis C virus responses via Toll-like receptor 7. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[22]  B. Rehermann,et al.  The liver as an immunological organ , 2006, Hepatology.

[23]  J. Olynyk,et al.  Author for Correspondence , 1996 .

[24]  B. Rehermann,et al.  The liver as an immunological organ , 2004 .

[25]  R. Kastelein,et al.  TGF-beta, a 'double agent' in the immune pathology war. , 2006, Nature immunology.

[26]  M. Alison,et al.  Liver cancer: the role of stem cells , 2005, Cell proliferation.

[27]  K. Hayashi,et al.  Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2‐acetylaminofluorene/partial hepatectomy model in rats , 2005, Journal of gastroenterology and hepatology.

[28]  S. Thorgeirsson,et al.  Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion , 2005, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[29]  G. McCaughan,et al.  Intrahepatic immunity: a tale of two sites? , 2005, Trends in immunology.

[30]  N. Fausto Tweaking liver progenitor cells , 2005, Nature Medicine.

[31]  C. Ambrose,et al.  TWEAK induces liver progenitor cell proliferation. , 2005, The Journal of clinical investigation.

[32]  J. Olynyk,et al.  Liver inflammation and cytokine production, but not acute phase protein synthesis, accompany the adult liver progenitor (oval) cell response to chronic liver injury , 2005, Immunology and cell biology.

[33]  L. Van Kaer,et al.  Hepatocytes Express Abundant Surface Class I MHC and Efficiently Use Transporter Associated with Antigen Processing, Tapasin, and Low Molecular Weight Polypeptide Proteasome Subunit Components of Antigen Processing and Presentation Pathway1 , 2005, The Journal of Immunology.

[34]  J. Olynyk,et al.  Hepatic expression of the tumor necrosis factor family member lymphotoxin‐β is regulated by interleukin (IL)‐6 and IL‐1β: transcriptional control mechanisms in oval cells and hepatoma cell lines , 2005, Liver international : official journal of the International Association for the Study of the Liver.

[35]  N. Fausto,et al.  Mechanisms of liver regeneration and their clinical implications. , 2005, Journal of hepato-biliary-pancreatic surgery.

[36]  G. Morgan,et al.  Dose‐ and time‐dependent oval cell reaction in acetaminophen‐induced murine liver injury , 2005, Hepatology.

[37]  J. Olynyk,et al.  Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture. , 2005, Experimental cell research.

[38]  Jean S. Campbell,et al.  Differential regulation of rodent hepatocyte and oval cell proliferation by interferon γ , 2005, Hepatology.

[39]  G. Michalopoulos,et al.  Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury , 2005, Hepatology.

[40]  M. Smyth,et al.  Differential lymphotoxin‐β and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury , 2005, Hepatology.

[41]  David C. Lee,et al.  Heparin-binding Epidermal Growth Factor-like Growth Factor Links Hepatocyte Priming with Cell Cycle Progression during Liver Regeneration* , 2005, Journal of Biological Chemistry.

[42]  R. Bataller,et al.  Amendment history : Corrigendum ( April 2005 ) Liver fibrosis Ramón Bataller , 2018 .

[43]  G. D'offizi,et al.  CD1d expression by hepatocytes is a main restriction element for intrahepatic T-cell recognition. , 2005, Journal of biological regulators and homeostatic agents.

[44]  N. Martin,et al.  Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat. , 2004, The American journal of pathology.

[45]  G. Yeoh,et al.  Direct effects of interleukin‐6 on liver progenitor oval cells in culture , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[46]  Jonas Larsson,et al.  Intact signaling by transforming growth factor β is not required for termination of liver regeneration in mice , 2004, Hepatology.

[47]  R. Taub Liver regeneration: from myth to mechanism , 2004, Nature Reviews Molecular Cell Biology.

[48]  S. Thorgeirsson,et al.  In vitro differentiation of rat liver derived stem cells results in sensitization to TNFα‐mediated apoptosis , 2004, Hepatology.

[49]  G. McCaughan,et al.  The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. , 2004, The Journal of clinical investigation.

[50]  F. Balkwill Cancer and the chemokine network , 2004, Nature Reviews Cancer.

[51]  P. Charneau,et al.  Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[52]  A. West,et al.  Nomenclature of the finer branches of the biliary tree: Canals, ductules, and ductular reactions in human livers , 2004, Hepatology.

[53]  A. Miyajima,et al.  Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M receptor knockout mice , 2004, Hepatology.

[54]  G. Yeoh,et al.  TNF/LTα double knockout mice display abnormal inflammatory and regenerative responses to acute and chronic liver injury , 2004, Cell and Tissue Research.

[55]  M. Alison Characterization of the Differentiation Capacity of Rat-Derived Hepatic Stem Cells , 2003, Seminars in liver disease.

[56]  T. Roskams,et al.  Progenitor cells in diseased human liver. , 2003, Seminars in liver disease.

[57]  T. Roskams,et al.  Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. , 2003, The American journal of pathology.

[58]  P. Knolle,et al.  Control of immune responses by savenger liver endothelial cells. , 2003, Swiss medical weekly.

[59]  A. West,et al.  Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells. , 2003, Journal of hepatology.

[60]  J. Olynyk,et al.  Upregulation of lymphotoxin β expression in liver progenitor (oval) cells in chronic hepatitis C , 2003 .

[61]  E. Scott,et al.  Mouse A6–positive hepatic oval cells also express several hematopoietic stem cell markers , 2003, Hepatology.

[62]  N. Van Rooijen,et al.  ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice. , 2003, Gastroenterology.

[63]  J. Albrecht,et al.  Evidence That Cyclin D1 Mediates Both Growth and Proliferation Downstream of TOR in Hepatocytes* , 2003, The Journal of Biological Chemistry.

[64]  J. Olynyk,et al.  Upregulation of lymphotoxin beta expression in liver progenitor (oval) cells in chronic hepatitis C. , 2003, Gut.

[65]  E. Sandgren,et al.  Hepatic microenvironment affects oval cell localization in albumin-urokinase-type plasminogen activator transgenic mice. , 2003, The American journal of pathology.

[66]  Humphrey Hodgson,et al.  The role of non-parenchymal cells in liver growth. , 2002, Seminars in cell & developmental biology.

[67]  L. Koniaris,et al.  Cytokine-Responsive Gene-2/IFN-Inducible Protein-10 Expression in Multiple Models of Liver and Bile Duct Injury Suggests a Role in Tissue Regeneration1 , 2001, The Journal of Immunology.

[68]  B. Petersen Hepatic "stem" cells: coming full circle. , 2001, Blood cells, molecules & diseases.

[69]  S. Thorgeirsson,et al.  Origin and structural evolution of the early proliferating oval cells in rat liver. , 2001, The American journal of pathology.

[70]  A. Sette,et al.  Virus‐specific CD8+ T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection , 2001, European journal of immunology.

[71]  P. Knolle,et al.  Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. , 2001, Archivum immunologiae et therapiae experimentalis.

[72]  N. Fausto,et al.  Impaired Preneoplastic Changes and Liver Tumor Formation in Tumor Necrosis Factor Receptor Type 1 Knockout Mice , 2000, The Journal of experimental medicine.

[73]  H. Ljunggren,et al.  Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance , 2000, Nature Medicine.

[74]  T. Roskams,et al.  Deep intralobular extension of human hepatic ‘progenitor cells’ correlates with parenchymal inflammation in chronic viral hepatitis: can ‘progenitor cells’ migrate? , 2000, The Journal of pathology.

[75]  J. Lunz,et al.  Concanavalin A simultaneously primes liver hematopoietic and epithelial progenitor cells for parallel expansion during liver regeneration after partial hepatectomy in mice , 2000, Hepatology.

[76]  H. Saito,et al.  Perihepatic lymphadenopathy in chronic liver diseases , 2000, Journal of gastroenterology and hepatology.

[77]  Guido Gerken,et al.  Local control of the immune response in the liver , 2000, Immunological reviews.

[78]  L. Yin,et al.  Proliferation of hepatic lineage cells of normal C57BL and interleukin‐6 knockout mice after cocaine‐induced periportal injury , 2000, Hepatology.

[79]  D. Metz,et al.  The liver as a site of T‐cell apoptosis: graveyard, or killing field? , 2000, Immunological reviews.

[80]  D. Doherty,et al.  Innate and adaptive lymphoid cells in the human liver , 2000, Immunological reviews.

[81]  S. Friedman Molecular Regulation of Hepatic Fibrosis, an Integrated Cellular Response to Tissue Injury* , 2000, The Journal of Biological Chemistry.

[82]  L. Rogge,et al.  IL‐12 receptor regulation in IL‐12‐deficient BALB / c and C57BL / 6 mice , 2000, European journal of immunology.

[83]  V. Desmet,et al.  The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. , 1999, Journal of hepatology.

[84]  M. Serra,et al.  Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis. , 2000, Journal of hepatology.

[85]  S. Thorgeirsson,et al.  Modulation of the gene network connected to interferon-γ in liver regeneration from oval cells , 1999 .

[86]  C. Rabourdin-Combe,et al.  Death by neglect as a deletional mechanism of peripheral tolerance. , 1999, International immunology.

[87]  Y. Ito,et al.  Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[88]  Yoshiaki Ito,et al.  Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer , 1999, The EMBO journal.

[89]  A. Demetris,et al.  Mitosis and apoptosis in the liver of interleukin‐6–deficient mice after partial hepatectomy , 1999, Hepatology.

[90]  J. Olynyk,et al.  Oval cell numbers in human chronic liver diseases are directly related to disease severity. , 1999, The American journal of pathology.

[91]  G. Gerken,et al.  Endotoxin down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells. , 1999, Journal of immunology.

[92]  P. van Eyken,et al.  Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. , 1998, Journal of hepatology.

[93]  S. Thorgeirsson,et al.  Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver , 1998, Hepatology.

[94]  B. Vainer,et al.  Interleukin-15 and its role in chronic inflammatory diseases , 1998, Inflammation Research.

[95]  G. Michalopoulos,et al.  Hepatic oval cells express the hematopoietic stem cell marker thy‐1 in the rat , 1998, Hepatology.

[96]  B. Bacon,et al.  Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction. , 1998, The American journal of pathology.

[97]  C. Rabourdin-Combe,et al.  Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival , 1998, European journal of immunology.

[98]  T. Ishikawa,et al.  Serum levels of IL‐10, IL‐15 and soluble tumour necrosis factor‐alpha (TNF‐α) receptors in type C chronic liver disease , 1997, Clinical and experimental immunology.

[99]  E. Furth,et al.  Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice , 1996, Science.

[100]  S. Thung,et al.  Identification of bipotential progenitor cells in human liver regeneration. , 1996, Laboratory investigation; a journal of technical methods and pathology.

[101]  V. Fung,et al.  Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. , 1994, Science.

[102]  P. Godowski,et al.  In vivo response of hepatocytes to growth factors requires an initial priming stimulus , 1994, Hepatology.

[103]  S. Thorgeirsson,et al.  Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[104]  F. Oesch,et al.  Persistence of the cholangiocellular and hepatocellular lesions observed in rats fed a choline-deficient/DL-ethionine-supplemented diet. , 1992, Carcinogenesis.

[105]  H. Pitot,et al.  Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor , 1991, Hepatology.

[106]  G. Schütz,et al.  Hepatocyte differentiation in vitro: initiation of tyrosine aminotransferase expression in cultured fetal rat hepatocytes , 1989, The Journal of cell biology.

[107]  N. Fausto,et al.  Production of hepatocellular carcinoma by oval cells: cell cycle expression of c-myc and p53 at different stages of oval cell transformation. , 1989, Cancer research.

[108]  J. Mead,et al.  Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[109]  R. Locksley,et al.  Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets , 1989, The Journal of experimental medicine.

[110]  C. Florén,et al.  Ultrasound Examination in Diffuse Liver Disease , 1987, Acta radiologica.

[111]  R S McCuskey,et al.  Phagocytosis, an unrecognized property of murine endothelial liver cells , 1986, Hepatology.

[112]  E. Farber Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene. , 1956, Cancer research.