Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.

[1]  B. Pizer,et al.  Posterior fossa syndrome following brain tumour resection: review of pathophysiology and a new hypothesis on its pathogenesis , 2015, Child's Nervous System.

[2]  C. Mullighan,et al.  Genomics in acute lymphoblastic leukaemia: insights and treatment implications , 2015, Nature Reviews Clinical Oncology.

[3]  D. Ellison,et al.  An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes , 2015, Nature Genetics.

[4]  T. Gajewski,et al.  Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity , 2015, Nature.

[5]  Vivien Marx,et al.  Cancer: A most exceptional response , 2015, Nature.

[6]  Kenneth R. Parrish,et al.  Improving drug delivery to primary and metastatic brain tumors: Strategies to overcome the blood–brain barrier , 2015, Clinical pharmacology and therapeutics.

[7]  F. Cappuzzo,et al.  First-line crizotinib versus chemotherapy in ALK-positive lung cancer. , 2014, The New England journal of medicine.

[8]  Giles W. Robinson,et al.  Medulloblastoma—translating discoveries from the bench to the bedside , 2014, Nature Reviews Clinical Oncology.

[9]  R. Jain,et al.  Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. , 2014, Cancer cell.

[10]  J. Nathans,et al.  Canonical WNT signaling components in vascular development and barrier formation. , 2014, The Journal of clinical investigation.

[11]  D. Rowitch,et al.  Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis , 2014, Cell.

[12]  K. Yeom,et al.  MRI Surrogates for Molecular Subgroups of Medulloblastoma , 2014, American Journal of Neuroradiology.

[13]  Michael Kahn,et al.  Can we safely target the WNT pathway? , 2014, Nature Reviews Drug Discovery.

[14]  C. Kuo,et al.  Developmental and pathological angiogenesis in the central nervous system , 2014, Cellular and Molecular Life Sciences.

[15]  A. Biankin,et al.  Mining the genomes of exceptional responders , 2014, Nature Reviews Cancer.

[16]  Roland Eils,et al.  Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. , 2014, Cancer cell.

[17]  Christina S. Leslie,et al.  CSF-1R inhibition alters macrophage polarization and blocks glioma progression , 2013, Nature Medicine.

[18]  M. Junttila,et al.  Influence of tumour micro-environment heterogeneity on therapeutic response , 2013, Nature.

[19]  Scott L. Pomeroy,et al.  Medulloblastomics: the end of the beginning , 2012, Nature Reviews Cancer.

[20]  C. Sander,et al.  Genome Sequencing Identifies a Basis for Everolimus Sensitivity , 2012, Science.

[21]  K. Plate,et al.  Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression , 2012, The Journal of experimental medicine.

[22]  Steven J. M. Jones,et al.  Subgroup-specific structural variation across 1,000 medulloblastoma genomes , 2012, Nature.

[23]  Matthew J. Betts,et al.  Dissecting the genomic complexity underlying medulloblastoma , 2012, Nature.

[24]  Jill P. Mesirov,et al.  MEDULLOBLASTOMA EXOME SEQUENCING UNCOVERS SUBTYPE-SPECIFIC SOMATIC MUTATIONS , 2012, Nature.

[25]  Elaine R. Mardis,et al.  Novel mutations target distinct subgroups of medulloblastoma , 2012, Nature.

[26]  M. Roussel,et al.  A mouse model of the most aggressive subgroup of human medulloblastoma. , 2012, Cancer cell.

[27]  F. Charron,et al.  The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence , 2011, Science.

[28]  L. Pusztai,et al.  Gene expression profiling in breast cancer: classification, prognostication, and prediction , 2011, The Lancet.

[29]  W. Yung,et al.  An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. , 2011, Cancer cell.

[30]  Hendrik Witt,et al.  Medulloblastoma comprises four distinct molecular variants. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  Bengt R. Johansson,et al.  Pericytes regulate the blood–brain barrier , 2010, Nature.

[32]  B. Barres,et al.  Pericytes are required for blood–brain barrier integrity during embryogenesis , 2010, Nature.

[33]  B. Barres,et al.  The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells , 2010, PloS one.

[34]  Yiai Tong,et al.  Subtypes of medulloblastoma have distinct developmental origins , 2010, Nature.

[35]  G. Kruh,et al.  Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors. , 2010, Neuro-oncology.

[36]  M. Corada,et al.  The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. , 2010, Developmental cell.

[37]  J. Nathans,et al.  Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization , 2009, Cell.

[38]  R. Moon,et al.  Transcription-based reporters of Wnt/beta-catenin signaling. , 2009, Cold Spring Harbor protocols.

[39]  Calvin J Kuo,et al.  Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis , 2009, Proceedings of the National Academy of Sciences.

[40]  Andrew P. McMahon,et al.  Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature , 2008, Science.

[41]  Robert Machold,et al.  Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. , 2008, Cancer cell.

[42]  H. Aburatani,et al.  Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer , 2007, Nature.

[43]  K. Hynynen,et al.  Chemotherapy delivery issues in central nervous system malignancy: a reality check. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[44]  T. Merchant,et al.  Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. , 2006, The Lancet. Oncology.

[45]  T. Curran,et al.  Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[46]  M. Hatten,et al.  The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. , 2005, Genes & development.

[47]  Claire L Weston,et al.  beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[48]  J. Kessler,et al.  Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma , 2005, Development.

[49]  J. Heimans,et al.  Dose-related vincristine-induced peripheral neuropathy with unexpected off-therapy worsening , 2005, Neurology.

[50]  R. Nusse,et al.  The Wnt signaling pathway in development and disease. , 2004, Annual review of cell and developmental biology.

[51]  S. Grossman,et al.  Penetration of intra-arterially administered vincristine in experimental brain tumor. , 2004, Neuro-oncology.

[52]  J A Firth,et al.  Endothelial barriers: from hypothetical pores to membrane proteins * , 2002, Journal of anatomy.

[53]  V. Perry,et al.  Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo , 1998, Neuroscience.

[54]  M. Scott,et al.  Altered neural cell fates and medulloblastoma in mouse patched mutants. , 1997, Science.

[55]  A. Schinkel,et al.  P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. , 1996, The Journal of clinical investigation.

[56]  A. Tonnel,et al.  Endothelial cells , 1991 .