The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1
暂无分享,去创建一个
[1] J. Blenis,et al. Structural and functional analysis of pp70S6k. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[2] B. Dérijard,et al. Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation (*) , 1995, The Journal of Biological Chemistry.
[3] A. Abo,et al. Rac GTPase interacts with GAPs and target proteins through multiple effector sites. , 1995, The EMBO journal.
[4] R. Pearson,et al. The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. , 1995, The EMBO journal.
[5] S. Schreiber,et al. Control of p70 S6 kinase by kinase activity of FRAP in vivo , 1995, Nature.
[6] R. Pearson,et al. Rapamycin, Wortmannin, and the Methylxanthine SQ20006 Inactivate p70s6k by Inducing Dephosphorylation of the Same Subset of Sites (*) , 1995, The Journal of Biological Chemistry.
[7] A. Ashworth,et al. An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1 , 1995, Science.
[8] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[9] L. Cantley,et al. Rho Family GTPases Bind to Phosphoinositide Kinases (*) , 1995, The Journal of Biological Chemistry.
[10] A. Sharrocks,et al. Integration of MAP kinase signal transduction pathways at the serum response element. , 1995, Science.
[11] M. Karin,et al. Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs , 1995, Cell.
[12] R. Treisman,et al. The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF , 1995, Cell.
[13] P. Crespo,et al. The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway , 1995, Cell.
[14] J. Avruch,et al. Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[15] Andrius Kazlauskas,et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.
[16] C. Nobes,et al. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia , 1995, Cell.
[17] P. Hawkins,et al. PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase , 1995, Current Biology.
[18] L. Lim,et al. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts , 1995, Molecular and cellular biology.
[19] Jiahuai Han,et al. Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*) , 1995, The Journal of Biological Chemistry.
[20] F. McCormick,et al. An essential role for Rac in Ras transformation , 1995, Nature.
[21] L. Mahadevan,et al. Parallel signal processing among mammalian MAPKs. , 1995, Trends in biochemical sciences.
[22] Jiahuai Han,et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms , 1995, Science.
[23] R. Abraham,et al. Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells (*) , 1995, The Journal of Biological Chemistry.
[24] J. Blenis,et al. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP , 1995, Molecular and cellular biology.
[25] A. Toker,et al. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. , 1994, The Journal of biological chemistry.
[26] G L Johnson,et al. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. , 1994, Science.
[27] A. Abo,et al. Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. , 1994, Science.
[28] S. Bagrodia,et al. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. , 1994, The Journal of biological chemistry.
[29] Paul Tempst,et al. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs , 1994, Cell.
[30] Andrius Kazlauskas,et al. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase , 1994, Nature.
[31] J. Blenis,et al. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation , 1994, Molecular and cellular biology.
[32] Stuart L. Schreiber,et al. A mammalian protein targeted by G1-arresting rapamycin–receptor complex , 1994, Nature.
[33] A. Fernández,et al. Nuclear localization of p85s6k: functional requirement for entry into S phase. , 1994, The EMBO journal.
[34] S. Aaronson,et al. Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. , 1994, The Journal of biological chemistry.
[35] L. Lim,et al. A brain serine/threonine protein kinase activated by Cdc42 and Rac1 , 1994, Nature.
[36] A. Ashkenazi,et al. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. , 1993, The Journal of biological chemistry.
[37] S. Elledge,et al. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 , 1993, Nature.
[38] L. Lim,et al. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42 , 1993, Nature.
[39] H. Lane,et al. p70s6k function is essential for G1 progression , 1993, Nature.
[40] A. Hall,et al. Different structural organization of Ras and Rho effector domains. , 1993, Oncogene.
[41] J. Exton,et al. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. , 1993, The Journal of biological chemistry.
[42] H. Hanafusa,et al. The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels. , 1992, Molecular and cellular biology.
[43] C. Crews,et al. Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[44] J. Avruch,et al. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. , 1992, Science.
[45] Anne J. Ridley,et al. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.
[46] Anne J. Ridley,et al. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling , 1992, Cell.
[47] G. Crabtree,et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase , 1992, Nature.
[48] G. Crabtree,et al. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.
[49] T. Roberts,et al. Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[50] S. Aaronson,et al. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product , 1991, Nature.
[51] J. Blenis,et al. Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. , 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[52] John Calvin Reed,et al. Differential regulation of the p72-74 RAF-1 kinase in 3T3 fibroblasts expressing ras or src oncogenes. , 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[53] L A Herzenberg,et al. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[54] C. Marshall,et al. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21 ras to the plasma membrane , 1990, Cell.
[55] D. Lowy,et al. Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1. , 1990, Science.
[56] N. Sigal,et al. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. , 1990, Journal of immunology.
[57] J. Hartley,et al. Thymic lymphoma induction by the AKT8 murine retrovirus , 1988, The Journal of experimental medicine.
[58] S. Aaronson,et al. Isolation of a new human oncogene from a diffuse B-cell lymphoma , 1985, Nature.
[59] J. Blenis,et al. The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. , 1995, Current opinion in cell biology.
[60] P. Hawkins,et al. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. , 1995, Journal of cell science.
[61] S. Ferrari,et al. S6 phosphorylation and the p70s6k/p85s6k. , 1994, Critical reviews in biochemistry and molecular biology.
[62] N. Williams. Both p21^ and pp60^ are required, but neither is sufficient, to activate the Raf-1 kinase. , 1992 .