Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with new onset diabetes: a nationwide cohort study

Diabetes increases the risk of hepatocellular carcinoma (HCC), however, the time‐relationship between hepatitis B virus and diabetes for the development of HCC remains unclear.

[1]  R. Loomba,et al.  Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non‐alcoholic fatty liver disease , 2012, Alimentary pharmacology & therapeutics.

[2]  H. Adami,et al.  Role of diabetes mellitus in the etiology of hepatocellular carcinoma. , 2000, Journal of the National Cancer Institute.

[3]  E. Bugianesi,et al.  Obesity and liver cancer. , 2014, Clinics in liver disease.

[4]  N. Kato,et al.  Type 2 diabetes and hepatocellular carcinoma: A case–control study in patients with chronic hepatitis B , 2012, International journal of cancer.

[5]  Ding‐Shinn Chen,et al.  Increased risk of cirrhosis and its decompensation in chronic hepatitis B patients with newly diagnosed diabetes: a nationwide cohort study. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[6]  Jaw-Town Lin,et al.  Association between nucleoside analogues and risk of hepatitis B virus–related hepatocellular carcinoma recurrence following liver resection. , 2012, JAMA.

[7]  M. Sampson,et al.  Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in type 2 diabetes , 2006, Diabetologia.

[8]  H. El‐Serag,et al.  Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. , 2004, Gastroenterology.

[9]  Chien-Jen Chen,et al.  Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. , 2010, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[10]  Chien-Jen Chen,et al.  Hepatitis B e antigen and the risk of hepatocellular carcinoma. , 2002, The New England journal of medicine.

[11]  Chien-Jen Chen,et al.  Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. , 2013, American journal of epidemiology.

[12]  Lu-Yu Hwang,et al.  Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus , 2002, Hepatology.

[13]  Yu-Hsuan Lin,et al.  Agreement between self-reported and health insurance claims on utilization of health care: A population study. , 2009, Journal of clinical epidemiology.

[14]  Ching-Lan Cheng,et al.  Validation of the national health insurance research database with ischemic stroke cases in Taiwan , 2011, Pharmacoepidemiology and drug safety.

[15]  F. Hu,et al.  The global implications of diabetes and cancer , 2014, The Lancet.

[16]  G. Farrell Insulin resistance, obesity, and liver cancer. , 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[17]  Xilin Yang,et al.  Enhancers and attenuators of risk associations of chronic hepatitis B virus infection with hepatocellular carcinoma in type 2 diabetes. , 2013, Endocrine-related cancer.

[18]  D. Nelson,et al.  Review article: the management of hepatocellular carcinoma , 2010, Alimentary pharmacology & therapeutics.

[19]  R. Deyo,et al.  Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. , 1992, Journal of clinical epidemiology.

[20]  D. Seidel,et al.  Systematic review: the association between obesity and hepatocellular carcinoma – epidemiological evidence , 2010, Alimentary pharmacology & therapeutics.

[21]  C. la Vecchia,et al.  The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.

[22]  R O Morgan,et al.  Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study , 2005, Gut.

[23]  Qiwen Ben,et al.  Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: A systematic review and meta‐analysis of cohort studies , 2012, International journal of cancer.

[24]  M. Abraham,et al.  Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis , 2012, Hepatology.

[25]  Guan-Tarn Huang,et al.  Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. , 2006, JAMA.

[26]  R. Gray A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk , 1988 .

[27]  H. El‐Serag,et al.  The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[28]  Chien-Jen Chen,et al.  Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. , 2008, Gastroenterology.