The role of the DLPFC in inductive reasoning of MCI patients and normal agings: An fMRI study

Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal agings, and whether the activation pattern of this region was different between MCI patients and normal agings. The fMRI results indicated that MCI patients had no difference from normal agings in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal agings, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal agings. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of agings, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations.

[1]  C. Semenza,et al.  Inductive reasoning and implicit memory: evidence from intact and impaired memory systems , 2004, Neuropsychologia.

[2]  B. Tabashnik,et al.  Development time and resistance to Bt crops , 1999, Nature.

[3]  Vinod Goel,et al.  Differential involvement of left prefrontal cortexin inductive and deductive reasoning , 2004, Cognition.

[4]  Edward E. Smith,et al.  Inductive Reasoning in Alzheimer's Disease , 2001, Brain and Cognition.

[5]  長濱康弘,et al.  Cerebral activation during performance of a Card Sorting Test(カード分類検査の実行中に観察される大脳の賦活部位) , 1997 .

[6]  A. Ischebeck,et al.  An fMRI study of the numerical Stroop task in individuals with and without minimal cognitive impairment , 2008, Cortex.

[7]  Z. Katsarou,et al.  Deductive and Inductive Reasoning in Parkinson's Disease Patients and Normal Controls: Review and Experimental Evidence , 1997, Cortex.

[8]  Kewei Chen,et al.  Arithmetic processing in the brain shaped by cultures. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[9]  M S Gazzaniga,et al.  Dissociation of language and cognition. A psychological profile of two disconnected right hemispheres. , 1984, Brain : a journal of neurology.

[10]  Yiyu Yao,et al.  The Neural Mechanism of Human Numerical Inductive Reasoning Process: A Combined ERP and fMRI Study , 2006, WImBI.

[11]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[12]  Lars Nyberg,et al.  Altered Prefrontal Brain Activity in Persons at Risk for Alzheimer's Disease: An fMRI Study , 2003, International Psychogeriatrics.

[13]  Dawn Langdon,et al.  The Role of the Left Hemisphere in Verbal and Spatial Reasoning Tasks , 2000, Cortex.

[14]  James K. Kroger,et al.  Rostrolateral Prefrontal Cortex Involvement in Relational Integration during Reasoning , 2001, NeuroImage.

[15]  Ning Zhong,et al.  ERP characteristics of sentential inductive reasoning in time and frequency domains , 2010, Cognitive Systems Research.

[16]  P. Fox,et al.  Temporal dissociation of parallel processing in the human subcortical outputs , 1999, Nature.

[17]  Andrew J Saykin,et al.  Cholinergic enhancement of frontal lobe activity in mild cognitive impairment. , 2004, Brain : a journal of neurology.

[18]  S. Kapur,et al.  The seats of reason? An imaging study of deductive and inductive reasoning , 1997, Neuroreport.

[19]  C. Martin,et al.  Dyscalculia in the early stages of Alzheimer's disease , 1999, Acta neurologica Scandinavica.

[20]  A. Drzezga,et al.  Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[21]  L M Parsons,et al.  New Evidence for Distinct Right and Left Brain Systems for Deductive versus Probabilistic Reasoning. , 2001, Cerebral cortex.