Convexity dural chondroma: a case report with pathological and molecular analysis.

Chondromas are rare benign tumors that commonly originate from the base of the skull, while those arising from the dura mater are less common. Although the molecular mechanism underlying its pathogenesis remains largely unknown, 12q13-15 rearrangements followed by the activation of HMGA2, which is associated with cell proliferation, have been reported in soft tissue chondromas. A recent comprehensive analysis of mesenchymal tumors identified an IDH1/2 mutation in cartilaginous tumors. However, these alterations have not yet been examined in dural chondromas. We here described clinical and pathological features in a new case of convexity dural chondroma with the wildtype IDH1/2 and expression of HMGA2 and reviewed the relevant literature.