Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol.

[1]  S. Hamm-Alvarez,et al.  The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. , 2008, American journal of physiology. Cell physiology.

[2]  M. Edman,et al.  Characterization of β-hexosaminidase secretion in rabbit lacrimal gland , 2006 .

[3]  L. Medina-Kauwe,et al.  Novel Fiber-Dependent Entry Mechanism for Adenovirus Serotype 5 in LacrimalAcini , 2006, Journal of Virology.

[4]  S. Hamm-Alvarez,et al.  Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis. , 2006, Experimental eye research.

[5]  D. Zoukhri.  Effect of inflammation on lacrimal gland function. , 2006, Experimental eye research.

[6]  C. Ding,et al.  Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. , 2006, Experimental eye research.

[7]  M. Edman,et al.  Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland. , 2006, Experimental eye research.

[8]  M. Lemp.  Dry eye (Keratoconjunctivitis Sicca), rheumatoid arthritis, and Sjögren's syndrome. , 2005, American journal of ophthalmology.

[9]  D. Kalman,et al.  Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells , 2005, Journal of Cell Science.

[10]  C. Okamoto,et al.  Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. , 2005, American journal of physiology. Cell physiology.

[11]  C. Ding,et al.  Mucosal immunity and self-tolerance in the ocular surface system. , 2005, The ocular surface.

[12]  T. Ritter,et al.  Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis , 2005, Journal of autoimmune diseases.

[13]  L. Medina-Kauwe,et al.  Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland , 2004, Gene Therapy.

[14]  S. Hamm-Alvarez,et al.  Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. , 2004, Experimental eye research.

[15]  L. Labree,et al.  Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis. , 2004, Investigative ophthalmology & visual science.

[16]  S. Hamm-Alvarez,et al.  Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells , 2004, Journal of cellular physiology.

[17]  L. Medina-Kauwe,et al.  Modulation of secretory functions in epithelia by adenovirus capsid proteins. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[18]  M. Kessels,et al.  Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. , 2003, Molecular biology of the cell.

[19]  J. Buring,et al.  Prevalence of dry eye syndrome among US women. , 2003, American journal of ophthalmology.

[20]  S. Hamm-Alvarez,et al.  Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells , 2003, Journal of Cell Science.

[21]  T. Ritter,et al.  Tumor Necrosis Factor Inhibitor Gene Expression Suppresses Lacrimal Gland Immunopathology in a Rabbit Model of Autoimmune Dacryoadenitis , 2003, Cornea.

[22]  M. Trousdale,et al.  Lacrimal Histopathology and Ocular Surface Disease in a Rabbit Model of Autoimmune Dacryoadenitis , 2003, Cornea.

[23]  T. Ritter,et al.  Expression of IL-10 and TNF-Inhibitor Genes in Lacrimal Gland Epithelial Cells Suppresses Their Ability to Activate Lymphocytes , 2002, Cornea.

[24]  R. Cheney,et al.  Human myosin-Vc is a novel class V myosin expressed in epithelial cells. , 2002, Journal of cell science.

[25]  A. Solomon,et al.  The Diagnosis and Management of Dry Eye: A Twenty-five–Year Review , 2000, Cornea.

[26]  R. Fox,et al.  Sjögren’s syndrome: current therapies remain inadequate for a common disease , 2000, Expert opinion on investigational drugs.

[27]  S. Hamm-Alvarez,et al.  Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini , 2000, Current eye research.

[28]  C. Fathman,et al.  A gene therapy approach to treatment of autoimmune disease , 1998, Immunologic research.

[29]  S. Hamm-Alvarez,et al.  Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells. , 1998, Journal of cell science.

[30]  V. Tuohy,et al.  Gene therapy in the treatment of autoimmune disease. , 1998, Immunology today.

[31]  P. Robbins,et al.  Gene therapy in autoimmune diseases , 1998 .

[32]  Michael S. German,et al.  The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract , 1997, Nature Biotechnology.

[33]  S. Hamm-Alvarez,et al.  Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity. , 1997, Experimental eye research.

[34]  Ronald G. Crystal,et al.  Transfer of Genes to Humans: Early Lessons and Obstacles to Success , 1995, Science.

[35]  A. Mircheff,et al.  Fluid phase endocytosis by isolated rabbit lacrimal gland acinar cells. , 1995, Experimental eye research.

[36]  M. Segerberg-konttinen.  Focal adenitis in lacrimal and salivary glands. A post-mortem study. , 1988, Scandinavian journal of rheumatology.

[37]  H. Hidaka,et al.  Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. , 1987, The Journal of biological chemistry.