论文信息 - AS Triazine Acyclonucleosides: Potential Inhibitors of Pyrimidine Enzymes1

AS Triazine Acyclonucleosides: Potential Inhibitors of Pyrimidine Enzymes1

Abstract Seven as-triazine-3,5-dione acyclonucleosides were synthesized and evaluated as inhibitors of orotate phosphoribosyltransferase (OPRTase, EC 2.4.2.10), orotidine 5′-monophosphate decarboxylase (ODCase, EC 4.1.2.23), uridine phosphorylase (UrdPase, EC 2.4.2.3), and thymidine phosphorylase (dThdPase, EC 2.4.2.4).

S. Purkayastha | F. Naguib | R. P. Panzica | M. H. Kouni | B. H. Lazrek

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