Solid-phase synthesis of five-dimensional libraries via a tandem Petasis–Ugi multi-component condensation reaction

Abstract Five-dimensional libraries of dipeptide amides are readily prepared using a solid-phase tandem Petasis–Ugi multi-component condensation protocol on either a RINK amine or Universal RINK isonitrile resin. The method is practical and can be automated to prepare a large number of compounds useful for high throughput biological screening.