Sculponeatin A promotes the ETS1-SYVN1 interaction to induce SLC7A11/xCT-dependent ferroptosis in breast cancer.

[1]  Y. Si,et al.  The direct STAT3 inhibitor 6-ethoxydihydrosanguinarine exhibits anticancer activity in gastric cancer , 2022, Acta Materia Medica.

[2]  Yongqiang Liu,et al.  Silybin has therapeutic efficacy against non-small cell lung cancer through targeting of Skp2 , 2022, Acta Materia Medica.

[3]  Cristina Mayor-Ruiz,et al.  Chasing molecular glue degraders: screening approaches. , 2022, Chemical Society reviews.

[4]  Shasha Cheng,et al.  Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor preventing metastasis in triple-negative breast cancer cells , 2022, Acta Materia Medica.

[5]  N. Zheng,et al.  Defining molecular glues with a dual-nanobody cannabidiol sensor , 2022, Nature communications.

[6]  Shaoyan Hu,et al.  HUWE1 Causes an Immune Imbalance in Immune Thrombocytopenic Purpura by Reducing the Number and Function of Treg Cells Through the Ubiquitination Degradation of Ets-1 , 2021, Frontiers in Cell and Developmental Biology.

[7]  Jie Shen,et al.  G protein pathway suppressor 2 suppresses gastric cancer by destabilizing epidermal growth factor receptor , 2021, Cancer science.

[8]  Y. Liu,et al.  Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells , 2021, Acta Pharmacologica Sinica.

[9]  B. Jiang,et al.  KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma. , 2021, Cancer letters.

[10]  Y. Si,et al.  Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer. , 2021, Chinese journal of natural medicines.

[11]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[12]  G. Kroemer,et al.  Broadening horizons: the role of ferroptosis in cancer , 2021, Nature Reviews Clinical Oncology.

[13]  Hamid Ehsan,et al.  Relapsed breast cancer complicated by isolated brain metastasis , 2020, Clinical case reports.

[14]  L. Zhuang,et al.  Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy , 2020, Protein & Cell.

[15]  Peng Huang,et al.  xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling. , 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

[16]  Yanfen Liu,et al.  The E3 Ubiquitin Ligase SYVN1 Ubiquitinates Atlastins to Remodel the Endoplasmic Reticulum Network , 2020, iScience.

[17]  Xiaodong Liu,et al.  Cystine‐glutamate antiporter xCT as a therapeutic target for cancer , 2020, Cell biochemistry and function.

[18]  M. Barry,et al.  Health-related quality of life following breast reconstruction compared to total mastectomy and breast-conserving surgery among breast cancer survivors: a systematic review and meta-analysis , 2020, Breast Cancer.

[19]  P. Shang,et al.  Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. , 2020, Cancer letters.

[20]  Y. Liu,et al.  Ethoxysanguinarine, a Novel Direct Activator of AMP-Activated Protein Kinase, Induces Autophagy and Exhibits Therapeutic Potential in Breast Cancer Cells , 2020, Frontiers in Pharmacology.

[21]  Aimin Li,et al.  MiR-532-3p suppresses colorectal cancer progression by disrupting the ETS1/TGM2 axis-mediated Wnt/β-catenin signaling , 2019, Cell Death & Disease.

[22]  Xiang-Jun Lu,et al.  Web 3DNA 2.0 for the analysis, visualization, and modeling of 3D nucleic acid structures , 2019, Nucleic Acids Res..

[23]  P. Sorensen,et al.  Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance , 2019, Proceedings of the National Academy of Sciences.

[24]  Ying Liu,et al.  Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia. , 2019, Journal of pharmacological sciences.

[25]  Fan Wang,et al.  A thermosensitive gel based on w1/o/w2 multiple microemulsions for the vaginal delivery of small nucleic acid , 2019, Drug delivery.

[26]  A. Furlan,et al.  Ets-1 drives breast cancer cell angiogenic potential and interactions between breast cancer and endothelial cells , 2018, International journal of oncology.

[27]  Y. Liu,et al.  Polyphyllin I inhibits growth and invasion of cisplatin-resistant gastric cancer cells by partially inhibiting CIP2A/PP2A/Akt signaling axis. , 2018, Journal of pharmacological sciences.

[28]  Liduan Zheng,et al.  Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression , 2018, Oncogene.

[29]  J. Tagne,et al.  ETS1 regulates Twist1 transcription in a KrasG12D/Lkb1−/− metastatic lung tumor model of non-small cell lung cancer , 2018, Clinical & Experimental Metastasis.

[30]  Peter C. Hollenhorst,et al.  ETS1 induction by the microenvironment promotes ovarian cancer metastasis through focal adhesion kinase. , 2018, Cancer letters.

[31]  T. Liang,et al.  Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway , 2017, The Journal of Biological Chemistry.

[32]  Shanfa Lu,et al.  Overview of Medicinally Important Diterpenoids Derived from Plastids. , 2017, Mini reviews in medicinal chemistry.

[33]  Pei Zhou,et al.  HDOCK: a web server for protein–protein and protein–DNA/RNA docking based on a hybrid strategy , 2017, Nucleic Acids Res..

[34]  Y. Liu,et al.  Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy , 2016, Oncotarget.

[35]  A. Jemal,et al.  Cancer statistics in China, 2015 , 2016, CA: a cancer journal for clinicians.

[36]  J. Dittmer.  The role of the transcription factor Ets1 in carcinoma. , 2015, Seminars in cancer biology.

[37]  W. Gu,et al.  Ferroptosis as a p53-mediated activity during tumour suppression , 2015, Nature.

[38]  K. Itoh,et al.  Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition , 2014, Molecular and Cellular Biology.

[39]  Zhiping Weng,et al.  ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers , 2014, Bioinform..

[40]  Matthew E. Welsch,et al.  Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis , 2014, eLife.

[41]  Han-Dong Sun,et al.  Diterpenoids from Isodon sculponeatus. , 2014, Fitoterapia.

[42]  Peter M. Kasson,et al.  GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit , 2013, Bioinform..

[43]  Rajash Pallai,et al.  Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells , 2012, Transcription.

[44]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[45]  Wei‐Lie Xiao,et al.  ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity. , 2009, Journal of natural products.

[46]  G. Kachalova,et al.  Regulation of the transcription factor Ets‐1 by DNA‐mediated homo‐dimerization , 2008, The EMBO journal.

[47]  Wei‐Lie Xiao,et al.  Sculponins A–C, three new 6,7-seco-ent-kauranoids from Isodon sculponeatus , 2007 .

[48]  J. Baert,et al.  Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation , 2007, Oncogene.

[49]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[50]  L. Garrett-Sinha,et al.  Cellular and Molecular Life Sciences Review of Ets1 Structure, Function, and Roles in Immunity , 2022 .