Is More Neurogenesis Always Better?

The clinical relevance of increasing neurogenesis in the adult mammalian brain is being questioned as increasing the number of new neurons has positive effects on some brain functions but not others.

[1]  E. Kandel,et al.  Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus , 2006, Proceedings of the National Academy of Sciences.

[2]  M. Drew,et al.  Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment , 2006, Nature Neuroscience.

[3]  K. Jin,et al.  Alzheimer's disease drugs promote neurogenesis , 2006, Brain Research.

[4]  Tao Yang,et al.  Small molecule approaches for promoting neurogenesis. , 2006, Current Alzheimer research.

[5]  N. Barbaro,et al.  Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy , 2006, Annals of neurology.

[6]  L. Colgin,et al.  Society for Neuroscience , 2005, Nature.

[7]  J. Flier,et al.  Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance , 2005, Science.

[8]  Rene Hen,et al.  Young and excitable: the function of new neurons in the adult mammalian brain , 2005, Current Opinion in Neurobiology.

[9]  H. Cameron,et al.  New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors , 2005, The Journal of cell biology.

[10]  A. Becker,et al.  Increased neurogenesis in a rat ketamine model of schizophrenia , 2004, Biological Psychiatry.

[11]  J. Rawlins,et al.  Regional dissociations within the hippocampus—memory and anxiety , 2004, Neuroscience & Biobehavioral Reviews.

[12]  R. Hen,et al.  Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants , 2003, Science.

[13]  H. Cameron,et al.  Short‐term and long‐term survival of new neurons in the rat dentate gyrus , 2003, The Journal of comparative neurology.

[14]  Oleg Shupliakov,et al.  Evidence for neurogenesis in the adult mammalian substantia nigra , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Jack M Parent,et al.  Rat forebrain neurogenesis and striatal neuron replacement after focal stroke , 2002, Annals of neurology.

[16]  O. Lindvall,et al.  Neuronal replacement from endogenous precursors in the adult brain after stroke , 2002, Nature Medicine.

[17]  Eberhard Fuchs,et al.  Adult neurogenesis: a compensatory mechanism for neuronal damage , 2001, European Archives of Psychiatry and Clinical Neuroscience.

[18]  Eric J. Nestler,et al.  Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus , 2000, The Journal of Neuroscience.

[19]  F. Gage,et al.  Neurogenesis in the adult human hippocampus , 1998, Nature Medicine.

[20]  Jason S. Snyder,et al.  Inhibition of neurogenesis interferes with hippocampus‐dependent memory function , 2006, Hippocampus.

[21]  G. Kempermann,et al.  Lifespan Development and the Brain: Adult Neurogenesis , 2006 .

[22]  E. Gould,et al.  Neurogenesis may relate to some but not all types of hippocampal‐dependent learning , 2002, Hippocampus.

[23]  P. Rakic Progress: Neurogenesis in adult primate neocortex: an evaluation of the evidence , 2002, Nature Reviews Neuroscience.