Is pK OK?

Since Hasselbalch1 introduced his logarithmic form of Henderson's2 equation (pH = pK′ + log HC03-/αPC02) it has been used to define the acid–base status of patients by providing the means for the calculation of one of the three variables — pH, carbon dioxide tension (PC02), or bicarbonate concentration (HCO3- ) — from knowledge of the other two. In most clinical laboratories today, pH and PC02 are measured, and HC03- is calculated from the equation. However, there are pitfalls inherent in this use of the equation. It is often forgotten that the . . .

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