Evidence for a heritable predisposition to death due to influenza.

Animal model studies and human epidemiological studies have shown that some infectious diseases develop primarily in individuals with an inherited predisposition. A heritable contribution to the development of severe influenza virus infection (i.e., that which results in death) has not previously been hypothesized or tested. Evidence for a heritable contribution to death due to influenza was examined using a resource consisting of a genealogy of the Utah population linked to death certificates in Utah over a period of 100 years. The relative risks of death due to influenza were estimated for the relatives of 4,855 individuals who died of influenza. Both close and distant relatives of individuals who died of influenza were shown to have a significantly increased risk of dying of influenza, consistent with a combination of shared exposure and genetic effects. These data provide strong support for a heritable contribution to predisposition to death due to influenza.

[1]  N. Tien,et al.  Risk Factors for Human Infection with Avian Influenza A H5N1, Vietnam, 2004 , 2006, Emerging infectious diseases.

[2]  B. Horne,et al.  Evidence for a Heritable Component in Death Resulting From Aortic and Mitral Valve Diseases , 2004, Circulation.

[3]  Yi Guan,et al.  Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia , 2006, Nature Medicine.

[4]  Niall Johnson,et al.  Updating the Accounts: Global Mortality of the 1918-1920 "Spanish" Influenza Pandemic , 2002, Bulletin of the history of medicine.

[5]  A. Heinzmann,et al.  TLR-4 and CD14 Polymorphisms in Respiratory Syncytial Virus Associated Disease , 2007, Disease markers.

[6]  G. Malécot,et al.  Les mathématiques de l'hérédité , 1948 .

[7]  A A Hicks,et al.  Familial aggregation of Parkinson's disease in Iceland. , 2000, The New England journal of medicine.

[8]  M. Skolnick,et al.  Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. , 1992, Science.

[9]  A. Wallace,et al.  Who should get influenza vaccine? , 1993, Journal of American college health : J of ACH.

[10]  Alun Thomas,et al.  Familial Associations between Cancer Sites , 1999, Comput. Biomed. Res..

[11]  A. Macnalty.  The pandemic of influenza of 1918-1919. , 1946, The Medical press.

[12]  L. Jorde,et al.  Inbreeding in the Utah Mormons: an evaluation of estimates based on pedigrees, isonymy, and migration matrices , 1989, Annals of human genetics.

[13]  Timothy M. Uyeki,et al.  Family Clustering of Avian Influenza A (H5N1) , 2005, Emerging infectious diseases.

[14]  Ezekiel J Emanuel,et al.  Who Should Get Influenza Vaccine When Not All Can? , 2006, Science.

[15]  N. Camp,et al.  Lobular breast cancer: Excess familiality observed in the Utah Population Database , 2005, International journal of cancer.

[16]  Siavash Ghaffari,et al.  A candidate prostate cancer susceptibility gene at chromosome 17p , 2001, Nature Genetics.

[17]  T McLellan,et al.  Genetic distances between the Utah Mormons and related populations. , 1984, American journal of human genetics.

[18]  N. Camp,et al.  A genealogical assessment of heritable predisposition to aneurysms. , 2003, Journal of neurosurgery.

[19]  S. Narod,et al.  Genetic epidemiology of prostate cancer. , 1999, Biochimica et biophysica acta.

[20]  M. Skolnick,et al.  Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus , 1994, Nature Genetics.

[21]  Steven E. Bayer,et al.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.

[22]  David E. Swayne,et al.  Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus , 2006, Nature.

[23]  A. Cheung,et al.  A Population-Based Assessment of the Familial Component of Chronic Kidney Disease Mortality , 2006, American Journal of Nephrology.

[24]  B. Horne,et al.  Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database. , 2006, American heart journal.

[25]  M H Skolnick,et al.  Familiality of cancer in Utah. , 1994, Cancer research.