Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.

[1]  S. Cho,et al.  Magnolol Inhibits LPS-induced NF-κB/Rel Activation by Blocking p38 Kinase in Murine Macrophages. , 2010, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

[2]  M. Pan,et al.  Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice. , 2010, Journal of agricultural and food chemistry.

[3]  Y. Ho,et al.  Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1. , 2009, Journal of agricultural and food chemistry.

[4]  Jah-yao Liu,et al.  Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo. , 2009, Cancer letters.

[5]  K. Kang,et al.  Overexpression of ErbB2 induces invasion of MCF10A human breast epithelial cells via MMP-9. , 2009, Cancer letters.

[6]  J. Ahn,et al.  Ets-1 upregulates HER2-induced MMP-1 expression in breast cancer cells. , 2008, Biochemical and biophysical research communications.

[7]  B. Shen,et al.  HER2-dependent MMP-7 expression is mediated by activated STAT3. , 2008, Cellular signalling.

[8]  Wun-Jae Kim,et al.  Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells. , 2008, Biochemical pharmacology.

[9]  Jah-yao Liu,et al.  Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. , 2008, Carcinogenesis.

[10]  M. Moasser.  The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis , 2007, Oncogene.

[11]  Jah-yao Liu,et al.  Human manganese superoxide dismutase suppresses HER2/neu‐mediated breast cancer malignancy , 2007, FEBS letters.

[12]  Kuo-Hsin Chen,et al.  Mechanisms for the magnolol‐induced cell death of CGTH W‐2 thyroid carcinoma cells , 2007, Journal of cellular biochemistry.

[13]  T. Okamoto,et al.  Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor κB , 2007 .

[14]  Shyr‐Yi Lin,et al.  Involvement of Ras/Raf‐1/ERK actions in the magnolol‐induced upregulation of p21 and cell‐cycle arrest in colon cancer cells , 2007, Molecular carcinogenesis.

[15]  H. Cheung,et al.  Magnolol suppresses NF-κB activation and NF-κB regulated gene expression through inhibition of IkappaB kinase activation , 2007 .

[16]  R. Zeillinger,et al.  In ovarian cancer the prognostic influence of HER2/neu is not dependent on the CXCR4/SDF-1 signalling pathway , 2007, British Journal of Cancer.

[17]  M. Ono,et al.  Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs , 2006, Clinical Cancer Research.

[18]  B. Aggarwal,et al.  Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-κB Activation Pathway , 2006, Molecular Cancer Research.

[19]  Xianglin Shi,et al.  MMP‐2 mediates ethanol‐induced invasion of mammary epithelial cells over‐expressing ErbB2 , 2006, International journal of cancer.

[20]  A. Dueñas-González,et al.  Prognostic, predictive and therapeutic implications of HER2 in invasive epithelial ovarian cancer. , 2006, Cancer treatment reviews.

[21]  Ming Tan,et al.  ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. , 2006, Cancer research.

[22]  E. Musgrove.  Cyclins: Roles in mitogenic signaling and oncogenic transformation , 2006, Growth factors.

[23]  H. Lane,et al.  ERBB receptors and cancer: the complexity of targeted inhibitors , 2005, Nature Reviews Cancer.

[24]  Xiaoke Huang,et al.  Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells. , 2005, Cancer research.

[25]  A. Moon,et al.  H-Ras-specific Activation of Rac-MKK3/6-p38 Pathway , 2005, Journal of Biological Chemistry.

[26]  W. Fong,et al.  Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid. , 2005, The international journal of biochemistry & cell biology.

[27]  V. Kosma,et al.  Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Breast Cancer with a Special Reference to Activator Protein-2, HER2, and Prognosis , 2004, Clinical Cancer Research.

[28]  Eun-sook Kim,et al.  TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. , 2004, International journal of oncology.

[29]  S. Eccles,et al.  Signaling pathways required for matrix metalloproteinase‐9 induction by betacellulin in head‐and‐neck squamous carcinoma cells , 2004, International journal of cancer.

[30]  Jongsung Lee,et al.  In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. , 2004, European journal of pharmacology.

[31]  K. Makino,et al.  Upregulation of IKKα/IKKβ by integrin-linked kinase is required for HER2/neu-induced NF-κB antiapoptotic pathway , 2004, Oncogene.

[32]  H. Nagase,et al.  Inhibitory effect of magnolol on tumour metastasis in mice , 2003, Phytotherapy research : PTR.

[33]  Y. Mitsumoto,et al.  Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells. , 2003, European journal of pharmacology.

[34]  T. Tsai,et al.  Effector mechanism of magnolol‐induced apoptosis in human lung squamous carcinoma CH27 cells , 2003, British journal of pharmacology.

[35]  Moshe Oren,et al.  Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis , 2002, Oncogene.

[36]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[37]  Y. Ho,et al.  Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells , 2001, Molecular carcinogenesis.

[38]  M. Stack,et al.  Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association. , 2001, Cancer research.

[39]  C. C. Lin,et al.  Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis , 2001, Phytotherapy research : PTR.

[40]  Y. Yarden,et al.  Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.

[41]  J. P. Lee,et al.  Antifungal activity of magnolol and honokiol , 2000, Archives of pharmacal research.

[42]  C. Teng,et al.  Anti-inflammatory and analgesic effects of magnolol , 1992, Naunyn-Schmiedeberg's Archives of Pharmacology.

[43]  E. Rosenthal,et al.  Breast cancer cells with inhibition of p38α have decreased MMP-9 activity and exhibit decreased bone metastasis in mice , 2004, Clinical & Experimental Metastasis.