Synthesis and biological evaluation of new N-alkylcarbazole derivatives as STAT3 inhibitors: preliminary study.
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E. Novellino | A. Carcereri de Prati | M. Sala | Mariagrazia Napoli | C. Saturnino | M. Sinicropi | Hisanori Suzuki | C. Palladino | A. Botta | Chiara Palladino
[1] Mingyao Liu,et al. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway. , 2010, Carcinogenesis.
[2] Hanmant Gaikwad,et al. Synthesis and cytotoxicity evaluation of 1-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]-3-aryl-1H-pyrazole-5-carboxylic acid derivatives. , 2010, European journal of medicinal chemistry.
[3] P. Cohen,et al. Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. , 2010, Bioorganic & Medicinal Chemistry.
[4] B. Perry,et al. Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. , 2006, The Journal of investigative dermatology.
[5] B. Pfeiffer,et al. Synthesis and cytotoxic activity of pyranocarbazole analogues of ellipticine and acronycine. , 2004, Chemical & pharmaceutical bulletin.
[6] O. Moltedo,et al. Synthesis and preliminary biological evaluation of a new pyridocarbazole derivative covalently linked to a thymidine nucleoside as a potential targeted antitumoral agent. I. , 2003, Chemical & pharmaceutical bulletin.
[7] Hua Yu,et al. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth , 2002, Oncogene.
[8] R. Dhir,et al. Stat3 activation in prostatic carcinomas , 2002, The Prostate.
[9] D. Frank,et al. The role of STATs in apoptosis. , 2002, Current molecular medicine.
[10] J. Turkson,et al. STAT proteins: novel molecular targets for cancer drug discovery , 2000, Oncogene.
[11] L. Poulain,et al. Biological properties of 5,11-dimethyl-6H-pyrido[3,2-b]carbazoles: a new class of potent antitumour drugs. , 2000, Anti-cancer drug design.
[12] D. Tweardy,et al. Interleukin‐6 induces prostate cancer cell growth accompanied by activation of Stat3 signaling pathway , 2000, The Prostate.
[13] P. Rothman,et al. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. , 1997, Journal of immunology.
[14] C. Watson,et al. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. , 1995, British Journal of Cancer.
[15] J. Darnell,et al. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. , 1994, Science.
[16] G. Nabel,et al. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[17] Hua Yu,et al. Tumour immunology: Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment , 2007, Nature Reviews Immunology.
[18] J. Turkson,et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. , 1999, Immunity.
[19] C. Saturnino,et al. In vitro cytotoxicity of carbazole derivatives. V. 9-Halogeno-substituted 5,11-dimethyl-6H-pyrido[3,2-b]carbazoles , 1997 .
[20] J. Darnell,et al. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. , 1995, Annual review of biochemistry.
[21] P. Cranwell,et al. 683. A synthesis of ellipticine , 1962 .