Brief Report: Integration of PrEP Services Into Routine Antenatal and Postnatal Care Experiences From an Implementation Program in Western Kenya

Background: Programmatic approaches for delivering pre-exposure prophylaxis (PrEP) to pregnant and postpartum women in settings with high HIV burden are undefined. The PrEP Implementation for Young Women and Adolescents (PrIYA) Program developed approaches for delivering PrEP in maternal child health (MCH) clinics. Methods: Under the PrIYA Program, nurse-led teams worked with MCH staff at 16 public, faith-based, and private facilities in Kisumu, Kenya, to determine optimal clinic flow for PrEP integration into antenatal care (ANC) and postnatal care (PNC). A program-dedicated nurse facilitated integration. HIV-uninfected women were screened for behavioral risk factors; same-day PrEP was provided to interested and medically eligible women. PrEP and MCH services were evaluated using standardized flow mapping and time-and-motion surveys. Results: Clinics developed 2 approaches for integrating PrEP delivery within ANC/PNC: (1) co-delivery: ANC/PNC and PrEP services delivered by same MCH nurse or (2) sequential services: PrEP services after ANC/PNC by a PrEP-specialized nurse. Three clinics selected co-delivery and 13 sequential services, based on patient volume and space availability. Overall, 86 ANC/PNC visits were observed. Clients who initiated PrEP took a median of 18 minutes (interquartile range 15–26) for PrEP-related activities (risk assessment, PrEP counseling, creatinine testing, dispensation, and documentation) in addition to other routine ANC/PNC activities. For clients who declined PrEP, an additional 13 minutes (interquartile range 7–15) was spent on PrEP-related risk assessment and counseling. Conclusions: PrEP delivery within MCH used co-delivery or sequential approaches. The moderate additional time burden for PrEP initiation in MCH would likely decline with community awareness and innovations such as group/peer counseling or expedited dispensing.

[1]  J. Ickovics "Bundling" HIV prevention: integrating services to promote synergistic gain. , 2008, Preventive medicine.

[2]  O. Müller,et al.  Antenatal Care Services in Rural Uganda , 2012, Qualitative health research.

[3]  S. Rule,et al.  Subcutaneous vs intravenous rituximab in patients with non-Hodgkin lymphoma: a time and motion study in the United Kingdom , 2014, Journal of medical economics.

[4]  J. Hargreaves,et al.  Universal voluntary HIV testing in antenatal care settings: a review of the contribution of provider‐initiated testing & counselling , 2012, Tropical medicine & international health : TM & IH.

[5]  F. Bigirimana,et al.  Building Health System Capacity Through Implementation Research: Experience of INSPIRE—A Multi-country PMTCT Implementation Research Project , 2017, Journal of acquired immune deficiency syndromes.

[6]  M. Porta,et al.  A randomised controlled clinical trial of nurse-, dietitian- and pedagogistled Group Care for the management of Type 2 diabetes , 2008, Journal of endocrinological investigation.

[7]  S. Maman,et al.  Promoting male partner HIV testing and safer sexual decision making through secondary distribution of self-tests by HIV-negative female sex workers and women receiving antenatal and post-partum care in Kenya: a cohort study. , 2016, The lancet. HIV.

[8]  L. Wolf,et al.  Frequent detection of acute HIV infection in pregnant women , 2007, AIDS.

[9]  S. Lewin,et al.  The provision of TB and HIV/AIDS treatment support by lay health workers in South Africa: a time-and-motion study , 2014, Human Resources for Health.

[10]  Springer Fachmedien Wiesbaden,et al.  Service , 2018, Wirtschaftsinformatik Manag..

[11]  C. Zeh,et al.  Prevalence, incidence and correlates of HSV-2 infection in an HIV incidence adolescent and adult cohort study in western Kenya , 2017, PloS one.

[12]  S. Leshabari,et al.  CenteringPregnancy-Africa: a pilot of group antenatal care to address Millennium Development Goals. , 2013, Midwifery.

[13]  J. Baeten,et al.  “I Did Not Want to Give Birth to a Child Who has HIV”: Experiences Using PrEP During Pregnancy Among HIV-Uninfected Kenyan Women in HIV-Serodiscordant Couples , 2017, Journal of acquired immune deficiency syndromes.

[14]  K. Brown,et al.  Occupational stress, job satisfaction and job performance among hospital nurses in Kampala, Uganda. , 2011, Journal of nursing management.

[15]  C. Pfeiffer,et al.  Antenatal care in practice: an exploratory study in antenatal care clinics in the Kilombero Valley, south-eastern Tanzania , 2011, BMC pregnancy and childbirth.

[16]  Jennifer A. Unger,et al.  Sexual Behavior and Vaginal Practices During Pregnancy and Postpartum: Implications for HIV Prevention Strategies , 2017, Journal of acquired immune deficiency syndromes.

[17]  M. van der Doef,et al.  Job conditions, job satisfaction, somatic complaints and burnout among East African nurses. , 2012, Journal of clinical nursing.

[18]  L. Koenig,et al.  Adherence to antiretroviral medications for HIV pre-exposure prophylaxis: lessons learned from trials and treatment studies. , 2013, American journal of preventive medicine.

[19]  Katrien Fransen,et al.  Preexposure prophylaxis for HIV infection among African women. , 2012, The New England journal of medicine.

[20]  M. Petzold,et al.  Early antenatal care visit: a systematic analysis of regional and global levels and trends of coverage from 1990 to 2013 , 2017, The Lancet. Global health.

[21]  A. Milovic,et al.  Evaluation of the Nova StatSensor® XpressTM Creatinine Point-Of-Care Handheld Analyzer , 2015, PloS one.

[22]  L. Myer,et al.  Delivering preexposure prophylaxis to pregnant and breastfeeding women in Sub-Saharan Africa: the implementation science frontier. , 2017, AIDS.

[23]  M. Newell,et al.  The Contribution of Maternal HIV Seroconversion During Late Pregnancy and Breastfeeding to Mother-to-Child Transmission of HIV , 2012, Journal of acquired immune deficiency syndromes.

[24]  A. Jahn,et al.  How much time do health services spend on antenatal care? Implications for the introduction of the focused antenatal care model in Tanzania , 2006, BMC pregnancy and childbirth.

[25]  Stephen Pearson,et al.  The Implications of Shortages of Health Professionals for Maternal Health in Sub-Saharan Africa , 2006, Reproductive health matters.

[26]  Effects of a Prenatal Care Intervention on the Self-Concept and Self-Efficacy of Adolescent Mothers , 2001, Journal of Perinatal Education.

[27]  B. Mustanski,et al.  High Rate of Discontinuation May Diminish PrEP Coverage Among Young Men Who Have Sex with Men , 2018, AIDS and Behavior.

[28]  J. Ickovics,et al.  Pregnancy as a window of opportunity for HIV prevention: effects of an HIV intervention delivered within prenatal care. , 2009, American journal of public health.

[29]  Robert T. Chen,et al.  Correlates of prevalent HIV infection among adults and adolescents in the Kisumu incidence cohort study, Kisumu, Kenya , 2015, International journal of STD & AIDS.

[30]  B. Chi,et al.  The landscape for HIV pre-exposure prophylaxis during pregnancy and breastfeeding in Malawi and Zambia: A qualitative study , 2019, PloS one.

[31]  S. Maman,et al.  Promoting Partner Testing and Couples Testing through Secondary Distribution of HIV Self-Tests: A Randomized Clinical Trial , 2016, PLoS medicine.

[32]  C. Duncombe,et al.  Integrating antiretroviral therapy into antenatal care and maternal and child health settings: a systematic review and meta-analysis. , 2013, Bulletin of the World Health Organization.

[33]  N. Shaffer,et al.  Impact of Maternal HIV Seroconversion during Pregnancy on Early Mother to Child Transmission of HIV (MTCT) Measured at 4-8 Weeks Postpartum in South Africa 2011-2012: A National Population-Based Evaluation , 2015, PloS one.

[34]  Creating Sustainable Collaborations for Implementation Science: The Case of the NIH-PEPFAR PMTCT Implementation Science Alliance , 2016, Journal of acquired immune deficiency syndromes.

[35]  J. Haggerty,et al.  Providing information on pregnancy complications during antenatal visits: unmet educational needs in sub-Saharan Africa. , 2009, Health policy and planning.

[36]  Megha L Mehrotra,et al.  Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. , 2014, The Lancet. Infectious diseases.