Subversion of antigenic expression in neoplasia: Lessons from immunohistology of teratomas

Many examples of inappropriate expression of intermediate filaments and other cell identity markers are known to occur in diagnostic tumor pathology. In the present study, this subversion of antigenic differentiation in tumors has been investigated using teratomas as a model, as these unique tumors not only mimic developing tissues but also show carcinomatous elements. Ten cases of teratoma (eight immature, two mature) were studied immunohistochemically using a panel of 13 commonly used cell identity markers, including intermediate filaments. Examples of antigenic coexpression and transbarrier expression in various morphologically mature and immature tissues were noted to be similar to those seen in various tumors. Carcinomatous elements in teratomas were non‐reactive rather than showing antigenic aberrations. Hence, this study strengthens the proposition that antigenic subversion in neoplasia is related to the process of maturation and differentiation, rather than malignant transformation.

[1]  K. Joshi,et al.  Immunohistochemical analysis of human embryos and fetuses: an insight into the mechanism of subversion of antigenic differentiation in neoplasia. , 1997, Archives of pathology & laboratory medicine.

[2]  J. Chi,et al.  Immunohistochemical Detection of S-100, S-1OOα, S-100β Proteins, Glial Fibrillary Acidic Protein, and Neuron Specific Enolase in the Prenatal and Adult Human Salivary Glands , 1993 .

[3]  A. Gupta,et al.  Teratomas in pediatric age group: experience with 75 cases. , 1993, Indian pediatrics.

[4]  Y. Nakazato,et al.  Expression of intermediate filaments in neuroendocrine tumors. , 1990, Archives of pathology & laboratory medicine.

[5]  K. Notohara,et al.  Glial Fibrillary Acidic Protein Immunoreactivity of Chondrocytes in Immature and Mature Teratomas , 1990, Acta pathologica japonica.

[6]  S. Martin,et al.  Intermediate Filament Expression in Astrocytic Neoplasms , 1989, The American journal of surgical pathology.

[7]  K. Geisinger,et al.  Immature neural elements in immature teratomas. An immunohistochemical and ultrastructural study. , 1988, American journal of clinical pathology.

[8]  A. Gown,et al.  Smooth muscle cells can express cytokeratins of "simple" epithelium. Immunocytochemical and biochemical studies in vitro and in vivo. , 1988, The American journal of pathology.

[9]  N. Azumi,et al.  The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms. A comprehensive immunohistochemical study on formalin- and alcohol-fixed tumors. , 1987, American journal of clinical pathology.

[10]  V. Lehto,et al.  A dual expression of cytokeratin and neurofilaments in bronchial carcinoid cells , 1985, International journal of cancer.

[11]  R. Wollmann,et al.  S-100 protein in human chondrocytes , 1982, Nature.

[12]  J. Keeling,et al.  Teratomas in children. , 1973, Archives of disease in childhood.

[13]  J. Chi,et al.  Immunohistochemical detection of S-100, S-100 alpha, S-100 beta proteins, glial fibrillary acidic protein, and neuron specific enolase in the prenatal and adult human salivary glands. , 1993, Pathology, research and practice.