From systems biology to analytic problems: comment on the paper "On the interplay between mathematics and biology, hallmarks toward a new systems biology" by N. Bellomo et al.

The new systems approach in biological sciences proposed in [1] is a constructive reply to the hints of the scientific community [2] and opens new research paths toward developments of new mathematical methods to model the living matter. This comment focuses on some analytic and modeling issues which are somewhat related to my personal scientific knowhow. I look forward to the answer to them as a critical analysis on the topics presented in the following might contribute to research activity in the field and, specifically, to the complex interplay between mathematics and biology. Therefore, after some introductory comment, I pose, for each issue, a specific question.