A genomic search for linkage of neurofibromatosis to RFLPs.

Our initial attempt to map NF was directed towards chromosomes 4 and 19, both of which had provided positive evidence for linkage in previous reports. This analysis showed no evidence in support of either hypothesis. Our second attempt at mapping NF was a general search of the genome, analysing a set of markers selected according to their degree of polymorphism, chromosomal location, ease of use, and availability. Data for linkage analysis were obtained from 17 multiplex families which are segregating a gene for NF. Linkage analyses were performed using PAP. Of note is the lod score of +1.17 at a recombination fraction of 0.1 between NF and the centromere of chromosome 17.

[1]  M. Pericak-Vance,et al.  Genetic linkage of von Recklinghausen neurofibromatosis to the nerve growth factor receptor gene , 1987, Cell.

[2]  Y. Nakamura,et al.  Variable number of tandem repeat (VNTR) markers for human gene mapping. , 1987, Science.

[3]  M. Skolnick,et al.  The Genetic Aspects of Neurofibromatosis a , 1986, Annals of the New York Academy of Sciences.

[4]  M. Spence,et al.  Genetic Linkage Analysis of Neurofibromatosis with DNA Markers a , 1986, Annals of the New York Academy of Sciences.

[5]  H. Willard,et al.  Detection of restriction fragment length polymorphisms at the centromeres of human chromosomes by using chromosome-specific alpha satellite DNA probes: implications for development of centromere-based genetic linkage maps. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[6]  D. Shaw,et al.  Linkage analysis of peripheral neurofibromatosis (Von Recklinghausen disease) and chromosome 19 markers linked to myotonic dystrophy. , 1986, Journal of medical genetics.

[7]  M. Spence,et al.  Linkage analysis of neurofibromatosis (von Recklinghausen disease). , 1983, Journal of medical genetics.

[8]  A. Culebras,et al.  Coincidence of neurofibromatosis and myotonic dystrophy in a kindred. , 1981, Journal of medical genetics.

[9]  M. Skolnick,et al.  Linkage analysis of Von Recklinghausen neurofibromatosis: Chromosomes 4 and 19 , 1986, Genetic epidemiology.

[10]  E. Shooter,et al.  A discordant sibship analysis between beta-NGF and neurofibromatosis. , 1985, American journal of human genetics.