Shear modulus estimation with vibrating needle stimulation

An ultrasonic shear wave imaging technique is being developed for estimating the complex shear modulus of biphasic hydropolymers including soft biological tissues. A needle placed in the medium is vibrated along its axis to generate harmonic shear waves. Doppler pulses synchronously track particle motion to estimate shear wave propagation speed. Velocity estimation is improved by implementing a k-lag phase estimator. Fitting shear-wave speed estimates to the predicted dispersion relation curves obtained from two rheological models, we estimate the elastic and viscous components of the complex shear modulus. The dispersion equation estimated using the standard linear solid-body (Zener) model is compared with that from the Kelvin-Voigt model to estimate moduli in gelatin gels in the 50 to 450 Hz shear wave frequency bandwidth. Both models give comparable estimates that agree with independent shear rheometer measurements obtained at lower strain rates.

[1]  H. Kanai Propagation of vibration caused by electrical excitation in the normal human heart. , 2009, Ultrasound in medicine & biology.

[2]  Shigao Chen,et al.  Shearwave dispersion ultrasound vibrometry (SDUV) for measuring tissue elasticity and viscosity , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[3]  Y. Yamakoshi,et al.  Ultrasonic imaging of internal vibration of soft tissue under forced vibration , 1990, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  H. Kanai,et al.  Propagation of spontaneously actuated pulsive vibration in human heart wall and in vivo viscoelasticity estimation , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  Mamoru Yamamoto,et al.  Errors in the Determination of Wind Speed by Doppler Radar , 1989 .

[6]  Mostafa Fatemi,et al.  Quantifying elasticity and viscosity from measurement of shear wave speed dispersion. , 2004, The Journal of the Acoustical Society of America.

[7]  J. Jensen Estimation of Blood Velocities Using Ultrasound: A Signal Processing Approach , 1996 .

[8]  C. Kasai,et al.  Real-Time Two-Dimensional Blood Flow Imaging Using an Autocorrelation Technique , 1985, IEEE Transactions on Sonics and Ultrasonics.

[9]  Michael F Insana,et al.  Poro-viscoelastic behavior of gelatin hydrogels under compression-implications for bioelasticity imaging. , 2009, Journal of biomechanical engineering.

[10]  N. Tschoegl The Phenomenological Theory of Linear Viscoelastic Behavior , 1989 .

[11]  M. Zaman,et al.  The biomechanical integrin. , 2010, Journal of biomechanics.

[12]  A. Wineman,et al.  A quasi-correspondence principle for Quasi-Linear viscoelastic solids , 2008 .

[13]  Kenneth Hoyt,et al.  Real-time shear velocity imaging using sonoelastographic techniques. , 2007, Ultrasound in medicine & biology.

[14]  J. Greenleaf,et al.  Remote measurement of material properties from radiation force induced vibration of an embedded sphere. , 2002, The Journal of the Acoustical Society of America.

[15]  Caroline Maleke,et al.  Quantitative viscoelastic parameters measured by harmonic motion imaging , 2009, Physics in medicine and biology.

[16]  L. Khazanovich The elastic-viscoelastic correspondence principle for non-homogeneous materials with time translation non-invariant properties , 2008 .

[17]  Milan Makale,et al.  Cellular mechanobiology and cancer metastasis. , 2007, Birth defects research. Part C, Embryo today : reviews.

[18]  Michael F. Insana,et al.  Complex shear modulus of thermally-damaged liver , 2009, 2009 IEEE International Ultrasonics Symposium.

[19]  A. Manduca,et al.  Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. , 1995, Science.

[20]  Michael F. Insana,et al.  Doppler ultrasound systems designed for tumor blood flow imaging , 2004, IEEE Transactions on Instrumentation and Measurement.

[21]  Amit Jain,et al.  Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices. , 2010, Biomaterials.

[22]  José M. Carcione,et al.  Wave Fields in Real Media: Wave Propagation in Anisotropic, Anelastic and Porous Media , 2011 .

[23]  Marko Orescanin,et al.  Material properties from acoustic radiation force step response. , 2009, The Journal of the Acoustical Society of America.

[24]  S. Emelianov,et al.  Assessment of shear modulus of tissue using ultrasound radiation force acting on a spherical acoustic inhomogeneity , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[25]  T. Oliphant,et al.  Acoustic shear-wave imaging using echo ultrasound compared to magnetic resonance elastography. , 2000, Ultrasound in medicine & biology.

[26]  F. Windmeijer,et al.  R-Squared Measures for Count Data Regression Models With Applications to Health-Care Utilization , 1996 .

[27]  E. Madsen,et al.  Ultrasonic shear wave properties of soft tissues and tissuelike materials. , 1983, The Journal of the Acoustical Society of America.

[28]  M. Fink,et al.  Supersonic shear imaging: a new technique for soft tissue elasticity mapping , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[29]  Armando Manduca,et al.  Quantitative assessment of hepatic fibrosis in an animal model with magnetic resonance elastography , 2007, Magnetic resonance in medicine.

[30]  Pravas R. Mahapatra,et al.  Practical Algorithms for Mean Velocity Estimation in Pulse Doppler Weather Radars Using a Small Number of Samples , 1983, IEEE Transactions on Geoscience and Remote Sensing.

[31]  Michael F Insana,et al.  Ultrasonic measurements of breast viscoelasticity. , 2007, Medical physics.