A cancer-associated galactosyltransferase isoenzyme.

GALACTOSYLTRANSFERASE has been studied in human serum, and early reports failed to demonstrate an elevation of total serum galactosyltransferase in malignant disease.1 , 2 Subsequent electrophoretic studies from this laboratory revealed that, although the majority of the serum enzyme runs as a single broad peak on polyacrylamide gels, serum specimens from patients with cancer contain a second and electrophoretically distinct isoenzyme, referred to as galactosyltransferase isoenzyme II (or GT-II).3 , 4 In this report these initial findings are extended, and we present results on 387 patients with malignant and nonmalignant disorders, confirming the correlation of GT-II with cancer. Materials and Methods Patient Material Serum . . .

[1]  C. Ip,et al.  Increase in serum and tissue glycosyltransferases and glycosidases in tumor-bearing rats. , 1977, Cancer research.

[2]  D. Kessel,et al.  Variation of levels of plasma guanosine diphosphate L-fucose:beta-D-galactosyl alpha-2-L-fucosyltransferase in acute adult leukemia. , 1977, Cancer research.

[3]  D. Podolsky,et al.  Cancer-associated serum galactosyltransferase activity. Demonstration in an animal model system. , 1977, The Journal of biological chemistry.

[4]  D. Podolsky,et al.  Cancer-associated isoenzyme of serum galactosyltransferase. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[5]  D. Podolsky,et al.  Galactosyltransferase activities in human sera: detection of a cancer-associated isoenzyme. , 1975, Biochemical and biophysical research communications.

[6]  H. Bosmann,et al.  Alterations of Surface Properties of Chick Embryo Fibroblasts Infected with Four Rous Sarcoma Viruses Producing Distinctive Cell Transformation 1 , 1974, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[7]  T. Hall,et al.  Enzyme activity in invasive tumors of human breast and colon. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Y. S. Kim,et al.  Glycosyltransferases in human blood.I. Galactosyltransferase in human serum and erythrocyte membranes. , 1972, The Journal of clinical investigation.