Microchannel Reactors: Applications and Use in Process Development

Recent research results on microchannel reactors are reviewed with particular reference to their applications and use as a cost effective tool during process development tasks. The high surface to volume ratio, efficient heat and mass transfer characteristics, vastly improved fluid mixing etc., allow precision control of reaction with improved conversions, selectivities and yields of desired products. The reaction times are shorter as compared to the conventional reactors with less degradation and side products. Scalability and optimization are also significantly easier. The article reviews variety of applications to catalysis, polymers, advanced materials, biosystems, organic reaction etc., with emphasis on the related engineering science issues.

[1]  S. Ekström,et al.  Microfluidic components for protein characterization. , 2001, Journal of biotechnology.

[2]  Edward P.L. Roberts,et al.  Hydrodynamic voltammetry in microreactors: multiphase flow , 2002 .

[3]  T. Fukuyama,et al.  A Copper‐Free Sonogashira Coupling Reaction in Ionic Liquids and Its Application to a Microflow System for Efficient Catalyst Recycling. , 2002 .

[4]  B. Bockrath,et al.  A pulse-flow microreactor study of coal-catalyst interactions , 1992 .

[5]  Otto Woerz Microreactors as Tools in Chemical Research , 2001 .

[6]  H. Rase,et al.  AN AUTOMATIC PRECISION MICROREACTOR , 1965 .

[7]  Soomin Park,et al.  Preparation of melamine resin micro/nanocapsules by using a microreactor and telomeric surfactants , 2003 .

[8]  S. Haswell,et al.  The investigation of an equilibrium dependent reaction for the formation of enamines in a microchemical system. , 2001, Lab on a chip.

[9]  M. K. Sarkar,et al.  Kinetics of thermal cracking of light hydrocarbon mixture by pulsed microreactor , 1979 .

[10]  M. Morris,et al.  Effects of alkaline hydrolysis and dynamic coating on the electroosmotic flow in polymeric microfabricated channels. , 2000, Analytical chemistry.

[11]  Takehiko Kitamori,et al.  A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions , 2004, Science.

[12]  Paul Watts,et al.  1,4-addition of enolates to alpha,beta-unsaturated ketones within a micro reactor. , 2002, Lab on a chip.

[13]  Anthony F. Volpe,et al.  Gas phase oxidation of ethane to acetic acid using high-throughput screening in a massively parallel microfluidic reactor system , 2003 .

[14]  Klavs F. Jensen,et al.  Microfabricated Differential Reactor for Heterogeneous Gas Phase Catalyst Testing , 2002 .

[15]  B Allen,et al.  Design of a prototype miniature bioreactor for high throughput automated bioprocessing , 2003 .

[16]  Tom McCreedy,et al.  Fabrication techniques and materials commonly used for the production of microreactors and micro total analytical systems , 2000 .

[17]  K. Okuyama,et al.  Nanoparticle Separation in Salted Droplet Microreactors , 2002 .

[18]  G. Maria,et al.  Modelling and scaleup of the kinetics with deactivation of methylcyclohexane dehydrogenation for hydrogen energy storage , 1996 .

[19]  K. Sefiane,et al.  Simulation and Design of a Non-adiabatic Multiphase Microreactor , 2003 .

[20]  Brian H Warrington,et al.  A Hantzsch synthesis of 2-aminothiazoles performed in a heated microreactor system. , 2002, Lab on a chip.

[21]  Tibor Chován,et al.  Microfabricated devices in biotechnology and biochemical processing. , 2002, Trends in biotechnology.

[22]  Zengin,et al.  High-Throughput Testing of Heterogeneous Catalyst Libraries Using Array Microreactors and Mass Spectrometry. , 1999, Angewandte Chemie.

[23]  Computer simulation of transport processes in biosensor microreactors , 1998 .

[24]  H. Rase,et al.  Continuous Stirred Microreactors as a Laboratory Tool , 1978 .

[25]  Paul Watts,et al.  Green chemistry: synthesis in micro reactors , 2003 .

[26]  S. Haswell,et al.  The Application of Microreactor Technology for the Synthesis of 1,2-Azoles , 2004 .

[27]  Tom McCreedy,et al.  On-chip catalysis using a lithographically fabricated glass microreactor—the dehydration of alcohols using sulfated zirconia , 2000 .

[28]  M. Akhtar,et al.  Permutational organic synthesis in addressable microreactors (POSAMTM): An efficient, inexpensive and versatile solid-phase protocol for the preparation of libraries of compounds on the 0.01 to 1.0 millimole (or larger) scale , 1997 .

[29]  D. Agar,et al.  The capillary-microreactor: a new reactor concept for the intensification of heat and mass transfer in liquid–liquid reactions , 2003 .

[30]  Pierre M. Adler,et al.  Optimal design and operation of a separating microreactor , 1999 .

[31]  A. Rougé,et al.  Microchannel reactors for fast periodic operation: the catalytic dehydration of isopropanol , 2001 .

[32]  G. Gavalas,et al.  A multiple microreactor system for parallel catalyst preparation and testing , 2002 .

[33]  John M Woodley,et al.  The use of microscale processing technologies for quantification of biocatalytic Baeyer-Villiger oxidation kinetics. , 2002, Biotechnology and bioengineering.

[34]  G. D. Bellos,et al.  The use of a three phase microreactor to investigate HDS kinetics , 2003 .

[35]  Catalytic Cracking over Crystalline Aluminosilicates. I. Instantaneous Rate Measurements for Hexadecane Cracking , 1969 .

[36]  G. Whitesides,et al.  Catalytic activity of native enzymes during capillary electrophoresis: an enzymic microreactor , 1993 .

[37]  Shahriyar Taghavi-Moghadam,et al.  Microreaction Technology as a Novel Approach to Drug Design, Process Development and Reliability , 2001 .

[38]  J. Burns,et al.  Development of a Microreactor for Chemical Production , 1999 .

[39]  Evan O. Jones,et al.  High efficiency and low carbon monoxide micro-scale methanol processors , 2004 .

[40]  K. Mae,et al.  Production of titania nanoparticles by using a new microreactor assembled with same axle dual pipe , 2004 .

[41]  B. Bockrath,et al.  A Pulse Flow Microreactor Study of Hydrogen Spillover from Palladium on Carbon to Silica and Polyvinylphenol , 1997 .

[42]  S. Dukhin,et al.  Electrokinetic phenomena of the second kind and their applications , 1991 .

[43]  K. Westerterp,et al.  The particle as microreactor: catalytic propylene polymerizations with supported metallocenes and Ziegler-Natta catalysts , 1999 .

[44]  J. Büchs,et al.  Device for sterile online measurement of the oxygen transfer rate in shaking flasks. , 2001, Biochemical engineering journal.

[45]  J. Harris,et al.  Aromatization of propane over a zeolite catalyst in both a microreactor and pilot plant , 1992 .

[46]  S. Haswell,et al.  The aldol reaction of silyl enol ethers within a micro reactor. , 2001, Lab on a chip.

[47]  Paul Watts,et al.  Benchmarking of Microreactor Applications , 2004 .

[48]  J. Goodwin,et al.  Characterization of Catalytic Surfaces by Isotopic-Transient Kinetics during Steady-State Reaction , 1995 .

[49]  Tianhong Cui,et al.  Fabrication of microreactors for dehydrogenation of cyclohexane to benzene , 2000 .

[50]  Development of a microreactor-based parallel catalyst analysis system for synthesis gas conversion , 2003 .

[51]  Holger Löwe,et al.  Steering of Liquid Mixing Speed in Interdigital Micro Mixers – From Very Fast to Deliberately Slow Mixing , 2004 .

[52]  Colin Ramshaw,et al.  A Microreactor for the Nitration of Benzene and Toluene , 2002 .

[53]  H. Fierz,et al.  A New Multipurpose Microreactor for Process Safety Studies , 2003 .

[54]  G. Yablonskii,et al.  Moment-Based Analysis of Transient Response Catalytic Studies (TAP Experiment) , 1998 .

[55]  Peter Styring,et al.  The use of a novel microreactor for high throughput continuous flow organic synthesis , 2000 .

[56]  S. Goto,et al.  Simulation of membrane microreactor for fuel cell with methane feed , 2003 .

[57]  Hideaki Maeda,et al.  Preparation of functionalized nanostructures on microchannel surface and their use for enzyme microreactors , 2004 .

[58]  H. Günthard,et al.  Detection and identification of free radicals in the gaseous-phase ozonolysis of ethylene: microreactor-matrix ESR spectroscopy , 1983 .

[59]  K. Sotowa,et al.  Fabrication of a Microevaporator Equipped with a Piezoelectrically-Driven Diaphragm Pump , 2003 .

[60]  D. Schweich,et al.  Hydrodesulfurization catalyst evaluation in an upflow three-phase microreactor , 1998 .

[61]  S. Büttgenbach,et al.  A micro plasma reactor for fluorinated waste gas treatment , 2004 .

[62]  Frantisek Svec,et al.  Enzymatic microreactor-on-a-chip: protein mapping using trypsin immobilized on porous polymer monoliths molded in channels of microfluidic devices. , 2002, Analytical chemistry.

[63]  Wolfgang Ehrfeld,et al.  State-of-the-art in microreaction technology : concepts, manufacturing and applications , 1999 .

[64]  T. Becker,et al.  Air pollution monitoring using tin-oxide-based microreactor systems , 2000 .

[65]  Hongwu Cui,et al.  Simultaneous pyrolysis of ethane-propane mixture in pulsed microreactor system , 1986 .

[66]  M. Harada,et al.  Growth Processes for Nanometer-Scale Au-Particles in Water-in Oil Microemulsions , 1999 .

[67]  Zhicheng Zhang,et al.  In situ coating of microreactor inner wall with nickel nano-particles prepared by γ-irradiation in magnetic field , 2004 .

[68]  S. Haswell,et al.  On-chip separation of peptides prepared within a micro reactor. , 2003, Chemical communications.

[69]  David Linke,et al.  Application of microstructured reactor technology for the photochemical chlorination of alkylaromatics , 2002 .

[70]  S. E. Voltz,et al.  Application of a Kinetic Model for Comparison of Catalytic Cracking in a Fixed Bed Microreactor and a Fluidized Dense Bed , 1974 .

[71]  Asterios Gavriilidis,et al.  Catalyst preparation and deactivation issues for nitrobenzene hydrogenation in a microstructured falling film reactor , 2003 .

[72]  J. Chan,et al.  Mechanistic organic chemistry in a microreactor. Zeolite-controlled photooxidations of organic sulfides. , 2002, The Journal of organic chemistry.

[73]  S. K. Bej,et al.  Studies on the performance of a microscale trickle bed reactor using different sizes of diluent , 2000 .

[74]  Milena Koudelka-Hep,et al.  Microreactor and electrochemical detectors fabricated using Si and EPON SU-8 , 2000 .

[75]  N. Harries,et al.  A numerical model for segmented flow in a microreactor , 2003 .

[76]  J. Guin,et al.  Comparative study of gas-liquid mass transfer coefficients in stirred autoclaves, tubing bomb microreactors, and bubble columns , 1984 .

[77]  Nathalie Tanchoux,et al.  Microreactors for Dynamic, High Throughput Screening of Fluid/Liquid Molecular Catalysis , 2000 .

[78]  J. C. Schouten,et al.  Design of a microstructured reactor with integrated heat-exchanger for optimum performance of a highly exothermic reaction , 2001 .

[79]  Klaus Schubert,et al.  MlCROSTRUCTURE DEVICES FOR APPLICATIONS IN THERMAL AND CHEMICAL PROCESS ENGINEERING , 2023, Proceeding of Heat Transfer and Transport Phenomena in Microscale.

[80]  Lee M. Pua,et al.  Industrial Microchannel Devices: Where Are We Today? , 2003 .

[81]  G. Rao,et al.  Low-cost microbioreactor for high-throughput bioprocessing. , 2001, Biotechnology and bioengineering.

[82]  K. Yeung,et al.  An investigation of Knoevenagel condensation reaction in microreactors using a new zeolite catalyst , 2004 .

[83]  Hossein Salimi-Moosavi,et al.  Electroosmotic Pumping of Organic Solvents and Reagents in Microfabricated Reactor Chips , 1997 .

[84]  N. Mishchuk,et al.  Superfast Electrophoresis of Conducting Dispersed Particles , 1998 .

[85]  D. M. Nace Catalytic Cracking over Crystalline Aluminosilicates. Microreactor Study of Gas Oil Cracking , 1970 .

[86]  R. Takigiku,et al.  Online Microreactors/Capillary Electrophoresis/Mass Spectrometry for the Analysis of Proteins and Peptides , 1995 .

[87]  Hiroyuki Nakamura,et al.  Interface configuration of the two layered laminar flow in a curved microchannel , 2004 .

[88]  D. J. Harrison,et al.  Capillary electrophoresis and sample injection systems integrated on a planar glass chip , 1992 .

[89]  R. Chambers,et al.  Microreactors for elemental fluorine , 1999 .

[90]  Paul Watts,et al.  Investigation of racemisation in peptide synthesis within a micro reactor. , 2002, Lab on a chip.

[91]  Klavs F. Jensen,et al.  Design issues for membrane-based, gas phase microchemical systems , 2000 .

[92]  Menderes Levent,et al.  Production of hydrogen-rich gases from steam reforming of methane in an automatic catalytic microreactor , 2003 .

[93]  Peter Pfeifer,et al.  Water gas shift reaction and selective oxidation of CO in microreactors , 2004 .

[94]  Dionisios G. Vlachos,et al.  Microreactor Modeling for Hydrogen Production from Ammonia Decomposition on Ruthenium , 2004 .

[95]  E. Sahlin,et al.  Fabrication of microchannel structures in fluorinated ethylene propylene. , 2002, Analytical chemistry.

[96]  Edmund G Seebauer,et al.  Porous anodic alumina microreactors for production of hydrogen from ammonia , 2004 .

[97]  D. Vlachos Stochastic modeling of chemical microreactors with detailed kinetics—induction times and ignitions of H2 in air , 1998 .

[98]  J. C. Schouten,et al.  Development of the kinetic model of platinum catalyzed ammonia oxidation in a microreactor , 2002 .

[99]  K. Jensen Microreaction engineering * is small better? , 2001 .

[100]  C Gärtner,et al.  Polymer based micro-reactors. , 2001, Journal of biotechnology.

[101]  Robert Hermann,et al.  Methods for Intense Aeration, Growth, Storage, and Replication of Bacterial Strains in Microtiter Plates , 2000, Applied and Environmental Microbiology.

[102]  Sunwon Park,et al.  Modeling and Control of a Microthermal Cycler for DNA Polymerase Chain Reaction , 2003 .

[103]  E. Morgan,et al.  Versatile microreactor and extractor , 1986 .

[104]  M. Vellekoop,et al.  High-resolution liquid volume detection in sub-nanoliter reactors , 2000 .

[105]  T. Maeder,et al.  A microreactor-based system for the study of fast exothermic reactions in liquid phase: characterization of the system , 2004 .

[106]  Wolfgang Ehrfeld,et al.  Direct fluorination of toluene using elemental fluorine in gas/liquid microreactors , 2000 .

[107]  Sau Man Lai,et al.  Knoevenagel condensation reaction in zeolite membrane microreactor , 2003 .

[108]  D. M. Nace Catalytic Cracking over Crystalline Aluminosilicates. II. Application of Microreactor Technique to Investigation of Structural Effects of Hydrocarbon Reactants , 1969 .

[109]  Hydrogen production in a reverse-flow autothermal catalytic microreactor: From evidence of performance enhancement to innovative reactor design , 2003 .

[110]  Thomas Bayer,et al.  Micro mixing effects in continuous radical polymerization , 2000 .

[111]  S H DeWitt,et al.  Microreactors for chemical synthesis. , 1999, Current opinion in chemical biology.

[112]  Paul Watts,et al.  Micro Reactors: Principles and Applications in Organic Synthesis. , 2002 .

[113]  J. Dwyer,et al.  The catalytic isomerisation of cyclopropane over NaCoX zeolites using a pulsed Microreactor , 1978 .

[114]  Tatsuo Ushijima,et al.  New methods for increasing productivity by using microreactors of planar pumping and alternating pumping types , 2004 .

[115]  Jens Anders Branebjerg,et al.  Microfluidics-a review , 1993 .

[116]  D Weuster-Botz,et al.  Parallel substrate feeding and pH-control in shaking-flasks. , 2001, Biochemical engineering journal.

[117]  D. Rogers,et al.  DTA apparatus as a catalytic microreactor with on-line analysis of the products , 1989 .

[118]  Klavs F. Jensen,et al.  Microchemical systems: Status, challenges, and opportunities , 1999 .

[119]  G. Centi,et al.  The reaction mechanism of alkane selective oxidation on vanadyl pyrophosphate catalysts. Features gleaned from TAP reactor transient response studies , 1993 .

[120]  Y. Popineau,et al.  Acetylation of pea isolate in a torus microreactor. , 1997, Biotechnology and bioengineering.

[121]  M. G. Alonso-Amigo Polymer Microfabrication for Microarrays, Microreactors and Microfluidics , 2000 .

[122]  V. Hessel,et al.  Novel Liquid‐Flow Splitting Unit Specifically Made for Numbering‐Up of Liquid/Liquid Chemical Microprocessing , 2003 .

[123]  A. Maureen Rouhi MICROREACTORS EYED FOR INDUSTRIAL USE , 2004 .

[124]  F. Wurm,et al.  Small-scale bioreactor system for process development and optimization. , 2001, Biochemical engineering journal.

[125]  Paul Watts,et al.  Solution phase synthesis of β-peptides using micro reactors , 2002 .

[126]  K. Sotowa,et al.  Fabrication of Parallel Microchannel Reactors for Use in Catalyst Testing , 2002 .

[127]  G. Groppi,et al.  Kinetic measurements of CH4 combustion over a 10% PdO/ZrO2 catalyst using an annular flow microreactor , 2003 .

[128]  J. C. Schouten,et al.  Optimization of heat transfer characteristics, flow distribution, and reaction processing for a microstructured reactor/heat-exchanger for optimal performance in platinum catalyzed ammonia oxidation , 2003 .

[129]  M. D. Croon,et al.  Design of a molybdenum high throughput microreactor for high temperature screening of catalytic coatings , 2004 .

[130]  S. Haswell,et al.  Monitoring of chemical reactions within microreactors using an inverted Raman microscopic spectrometer , 2003, Electrophoresis.

[131]  R. Chambers,et al.  Elemental fluorine. Part 13. Gas-liquid thin film microreactors for selective direct fluorination. , 2001, Lab on a chip.

[132]  Ch. Wille,et al.  Synthesis of pigments in a three-stage microreactor pilot plant—an experimental technical report , 2004 .

[133]  William P Flanagan,et al.  Fluorescence spectroscopy and multivariate spectral descriptor analysis for high-throughput multiparameter optimization of polymerization conditions of combinatorial 96-microreactor arrays. , 2003, Journal of combinatorial chemistry.

[134]  David Wong,et al.  Bubble Behaviour in Three Phase Capillary Microreactors , 2003 .

[135]  Toshiro Higuchi,et al.  Novel microreactors for functional polymer beads , 2004 .

[136]  N. Mishchuk,et al.  Electroosmosis of the second kind , 1995 .

[137]  Zhicheng Zhang,et al.  Preparation of micron-size monodisperse poly(vinyl acetate) microspheres with γ-rays-initiated dispersion polymerization in microreactor , 2004 .

[138]  Klavs F. Jensen,et al.  Microfabricated cross-flow chemical reactor for catalyst testing , 2002 .

[139]  Holger Krummradt,et al.  Experiences with the use of microreactors in organic synthesis , 2000 .

[140]  Kurt M. VandenBussche,et al.  Novel tools to speed up the technology commercialization process , 2003 .

[141]  Götz Veser,et al.  Experimental and theoretical investigation of H2 oxidation in a high-temperature catalytic microreactor , 2001 .

[142]  Asterios Gavriilidis,et al.  Flow Distribution in Different Microreactors Scale-Out Geometries and the Effect on Manufacturing Tolerances and Channel Blocking , 2004 .

[143]  K. Jensen,et al.  Microchemical Systems for Direct Fluorination of Aromatics , 2001 .

[144]  S. Ekström,et al.  Improved performance in silicon enzyme microreactors obtained by homogeneous porous silicon carrier matrix. , 2002, Talanta.

[145]  N. Garti,et al.  Sucrose ester microemulsions as microreactors for model Maillard reaction , 2001 .

[146]  J. Köhler,et al.  Nanotiterplates for combinatorial chemistry. , 2001, Journal of biotechnology.

[147]  Frank J. Villani,et al.  Application of Microreactor Technology in Process Development , 2004 .

[148]  T. Laurell Biocatalytic porous silicon microreactors , 2002 .

[149]  Asterios Gavriilidis,et al.  Technology and Applications of Microengineered Reactors , 2002 .

[150]  N. Miyake,et al.  Microreactors for the synthesis of fluorinated materials , 2003 .

[151]  S. Haswell,et al.  Kumada-Corriu reactions in a pressure-driven microflow reactor. , 2001, Lab on a chip.

[152]  Volker Hessel,et al.  Microchemical Engineering: Components, Plant Concepts, User Acceptance – Part II , 2003 .

[153]  James E. Miller,et al.  Batch microreactor studies of lignin and lignin model compound depolymerization by bases in alcohol solvents , 1999 .