Fluid–structure interaction analysis of the left coronary artery with variable angulation

The aim of this study is to elucidate the correlation between coronary artery branch angulation, local mechanical and haemodynamic forces at the vicinity of bifurcation. Using a coupled fluid–structure interaction (FSI) modelling approach, five idealized left coronary artery models with various angles ranging from 70° to 110° were developed to investigate the influence of branch angulations. In addition, one CT image-based model was reconstructed to further demonstrate the medical application potential of the proposed FSI coupling method. The results show that the angulation strongly alters its mechanical stress distribution, and the instantaneous wall shear stress distributions are substantially moderated by the arterial wall compliance. As high tensile stress is hypothesized to cause stenosis, the left circumflex side bifurcation shoulder is indicated to induce atherosclerotic changes with a high tendency for wide-angled models.

[1]  Zhonghua Sun,et al.  Computation of hemodynamics in the left coronary artery with variable angulations. , 2011, Journal of biomechanics.

[2]  Yiannis Ventikos,et al.  Computational simulation of intracoronary flow based on real coronary geometry. , 2004, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[3]  Zhonghua Sun,et al.  Computational Fluid Dynamics Analysis of the Effect of Plaques in the Left Coronary Artery , 2012, Comput. Math. Methods Medicine.

[4]  R. M. Nerem,et al.  Coronary Artery Geometry and Its Fluid Mechanical Implications , 1983 .

[5]  S. Chien,et al.  Effects of mechanical forces on signal transduction and gene expression in endothelial cells. , 1998, Hypertension.

[6]  Yiannis S. Chatzizisis,et al.  Myocardial bridges are free from atherosclerosis: Overview of the underlying mechanisms , 2009 .

[7]  Foad Kabinejadian,et al.  Compliant model of a coupled sequential coronary arterial bypass graft: effects of vessel wall elasticity and non-Newtonian rheology on blood flow regime and hemodynamic parameters distribution. , 2012, Medical engineering & physics.

[8]  Jesper Swedenborg,et al.  McDonald's Blood Flow in Arteries , 2006 .

[9]  L. Boxt.  McDonald's blood flow in arteries , 1991, CardioVascular and Interventional Radiology.

[10]  J. Guilbert.  The world health report 2002 - reducing risks, promoting healthy life. , 2003, Education for health.

[11]  J. Ohayon,et al.  Unsteady blood flow and mass transfer of a human left coronary artery bifurcation: FSI vs. CFD , 2012 .

[12]  Kiao Inthavong,et al.  Image-based computational hemodynamics evaluation of atherosclerotic carotid bifurcation models , 2013, Comput. Biol. Medicine.

[13]  Zhonghua Sun,et al.  Multislice CT angiography assessment of left coronary artery: correlation between bifurcation angle and dimensions and development of coronary artery disease. , 2011, European journal of radiology.

[14]  R. Nerem,et al.  Fluid dynamics as a localizing factor for atherosclerosis : the proceedings of a symposium held at Heidelberg, FRG, June 18-20, 1982 , 1983 .

[15]  A. Zeiher,et al.  Endothelial Function: Cardiac Events , 2005, Circulation.

[16]  Toshio Kobayashi,et al.  Fluid-structure interaction modeling of blood flow and cerebral aneurysm: Significance of artery and aneurysm shapes , 2009 .

[17]  E. Edelman,et al.  Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. , 2007, Journal of the American College of Cardiology.

[18]  Kenji Takizawa,et al.  Space–time fluid–structure interaction modeling of patient‐specific cerebral aneurysms , 2011 .

[19]  J. M. Tarbell,et al.  A Computational Study of Flow in a Compliant Carotid Bifurcation–Stress Phase Angle Correlation with Shear Stress , 2005, Annals of Biomedical Engineering.

[20]  P. Serruys,et al.  A new imaging technique to study 3-D plaque and shear stress distribution in human coronary artery bifurcations in vivo. , 2007, Journal of biomechanics.

[21]  Guang-Zhong Yang,et al.  Fluid-structure interaction analysis of a patient-specific right coronary artery with physiological velocity and pressure waveforms , 2009 .

[22]  N. Cheshire,et al.  Fluid structure interaction of patient specific abdominal aortic aneurysms: a comparison with solid stress models , 2006, Biomedical engineering online.

[23]  S. Alper,et al.  Hemodynamic shear stress and its role in atherosclerosis. , 1999, JAMA.

[24]  Jia Lu,et al.  Fluid–structure interaction methods in biological flows with special emphasis on heart valve dynamics , 2010 .

[25]  P. Davies,et al.  Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology , 2009, Nature Clinical Practice Cardiovascular Medicine.

[26]  M. Thubrikar,et al.  Pressure-induced arterial wall stress and atherosclerosis. , 1995, The Annals of thoracic surgery.

[27]  Jacques Ohayon,et al.  Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture. , 2008, American journal of physiology. Heart and circulatory physiology.

[28]  C. R. Ethier,et al.  Intimal Thickness Is not Associated With Wall Shear Stress Patterns in the Human Right Coronary Artery , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[29]  J. Westerweel,et al.  In vivo whole-field blood velocity measurement techniques , 2007 .

[30]  P. Serruys,et al.  3-Dimensional bifurcation angle analysis in patients with left main disease: a substudy of the SYNTAX trial (SYNergy Between Percutaneous Coronary Intervention with TAXus and Cardiac Surgery). , 2010, JACC. Cardiovascular interventions.

[31]  Milan Sonka,et al.  Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. , 2007, European heart journal.

[32]  H. Ives,et al.  Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. , 1995, The Journal of clinical investigation.

[33]  Alexander D. Shkolnik,et al.  Fluid-structure interaction in abdominal aortic aneurysms: effects of asymmetry and wall thickness , 2005, Biomedical engineering online.

[34]  P. Serruys,et al.  The role of shear stress in the destabilization of vulnerable plaques and related therapeutic implications , 2005, Nature Clinical Practice Cardiovascular Medicine.

[35]  R. Schroter,et al.  Arterial Wall Shear and Distribution of Early Atheroma in Man , 1969, Nature.

[36]  G. Osol.  Mechanotransduction by vascular smooth muscle. , 1995, Journal of vascular research.

[37]  T. O'donnell,et al.  Pulsatile flow and atherosclerosis in the human carotid bifurcation: Positive correlation between plaque location and low and oscillating shear stress: Ku DN, Giddens DP, Zarins CK, et al. Arteriosclerosis 1985; 5: 293–302 , 1986 .

[38]  R. Abbate,et al.  Role of hemodynamic shear stress in cardiovascular disease. , 2011, Atherosclerosis.

[39]  D. Liepsch,et al.  Flow Characteristics in an Anatomically Realistic Compliant Carotid Artery Bifurcation Model. , 1999, Computer methods in biomechanics and biomedical engineering.

[40]  Yunlong Huo,et al.  Effects of vessel compliance on flow pattern in porcine epicardial right coronary arterial tree. , 2009, Journal of biomechanics.

[41]  G. Louridas,et al.  Wall shear stress in normal left coronary artery tree. , 2006, Journal of biomechanics.

[42]  A. Tedgui,et al.  Signal transduction of mechanical stresses in the vascular wall. , 1998, Hypertension.

[43]  Jiyuan Tu,et al.  Hemodynamics analysis of patient‐specific carotid bifurcation: A CFD model of downstream peripheral vascular impedance , 2013, International journal for numerical methods in biomedical engineering.

[44]  Guilbert Jj.  The world health report 2002 - reducing risks, promoting healthy life. , 2003 .

[45]  D. Ku,et al.  3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis. , 2009, Journal of biomechanical engineering.

[46]  M. Schwartz,et al.  The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[47]  R. Schroter,et al.  Atheroma and arterial wall shear - Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis , 1971, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[48]  N. Koshiba,et al.  Multiphysics simulation of blood flow and LDL transport in a porohyperelastic arterial wall model. , 2007, Journal of biomechanical engineering.

[49]  A. Hazel,et al.  Fluid-Structure Interaction in Internal Physiological Flows , 2011 .

[50]  H. Zahedmanesh,et al.  A method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments. , 2010, Journal of the mechanical behavior of biomedical materials.