Single-pixel coherent diffraction imaging

Complex-field imaging is indispensable for numerous applications at wavelengths from X-ray to THz, with amplitude describing transmittance (or reflectivity) and phase revealing intrinsic structure of the target object. Coherent diffraction imaging (CDI) employs iterative phase retrieval algorithms to process diffraction measurements and is the predominant non-interferometric method to image complex fields. However, the working spectrum of CDI is quite narrow, because the diffraction measurements on which it relies require dense array detection with ultra-high dynamic range. Here we report a single-pixel CDI technique that works for a wide waveband. A single-pixel detector instead of an array sensor is employed in the far field for detection. It repeatedly records the DC-only component of the diffracted wavefront scattered from an object as it is illuminated by a sequence of binary modulation patterns. This decreases the measurements' dynamic range by several orders of magnitude. We employ an efficient single-pixel phase-retrieval algorithm to jointly recover the object's 2D amplitude and phase maps from the 1D intensity-only measurements. No a priori object information is needed in the recovery process. We validate the technique's quantitative phase imaging nature using both calibrated phase objects and biological samples, and demonstrate its wide working spectrum with both 488-nm visible light and 980-nm near-infrared light. Our approach paves the way for complex-field imaging in a wider waveband where 2D detector arrays are not available, with broad applications in life and material sciences.

[1]  Garth J. Williams,et al.  Three-dimensional mapping of a deformation field inside a nanocrystal , 2006, Nature.

[2]  M. D. de Jonge,et al.  Fresnel coherent diffractive imaging. , 2006, Physical review letters.

[3]  Shuang Zhang,et al.  Electromagnetic reprogrammable coding-metasurface holograms , 2017, Nature Communications.

[4]  Aydogan Ozcan,et al.  Off-axis holography and micro-optics improve lab-on-a-chip imaging , 2017, Light, science & applications.

[5]  P. Thibault X-ray ptychography , 2011 .

[6]  E. Leith,et al.  Reconstructed Wavefronts and Communication Theory , 1962 .

[7]  C. Werner,et al.  Satellite radar interferometry: Two-dimensional phase unwrapping , 1988 .

[8]  J R Fienup,et al.  Phase retrieval algorithms: a comparison. , 1982, Applied optics.

[9]  Yonina C. Eldar,et al.  Phase Retrieval with Application to Optical Imaging: A contemporary overview , 2015, IEEE Signal Processing Magazine.

[10]  Guoan Zheng,et al.  Reflective Fourier ptychography , 2016, Journal of biomedical optics.

[11]  O. Bunk,et al.  High-Resolution Scanning X-ray Diffraction Microscopy , 2008, Science.

[12]  Miles J. Padgett,et al.  Principles and prospects for single-pixel imaging , 2018, Nature Photonics.

[13]  Duncan Graham-Rowe,et al.  Terahertz takes to the stage , 2007 .

[14]  Y. Zel’dovich,et al.  Principles of phase conjugation , 1985 .

[15]  I. Robinson,et al.  Reconstruction of the shapes of gold nanocrystals using coherent x-ray diffraction. , 2001, Physical review letters.

[16]  Wolfgang Osten,et al.  Quantitative phase imaging using a deep UV LED source. , 2014, Optics letters.

[17]  D. Gabor A New Microscopic Principle , 1948, Nature.

[18]  Wilhelm Burger,et al.  Digital Image Processing - An Algorithmic Introduction using Java , 2008, Texts in Computer Science.

[19]  A. Kirsch An Introduction to the Mathematical Theory of Inverse Problems , 1996, Applied Mathematical Sciences.

[20]  Shaowei Jiang,et al.  Super-resolution microscopy via ptychographic structured modulation of a diffuser. , 2019, Optics letters.

[21]  Enrique Tajahuerce,et al.  High sampling rate single-pixel digital holography system employing a DMD and phase-encoded patterns. , 2018, Optics express.

[22]  Andrea Alù,et al.  Machine-learning reprogrammable metasurface imager , 2019, Nature Communications.

[23]  S. D. Babacan,et al.  White-light diffraction tomography of unlabelled live cells , 2014, Nature Photonics.

[24]  Gabriel Popescu,et al.  Quantitative phase imaging of live cells using fast Fourier phase microscopy. , 2007, Applied optics.

[25]  M. Murnane,et al.  Tabletop nanometer extreme ultraviolet imaging in an extended reflection mode using coherent Fresnel ptychography , 2013, 1312.2049.

[26]  E. Tajahuerce,et al.  Single-pixel digital holography with phase-encoded illumination. , 2017, Optics express.

[27]  J. Rodenburg Ptychography and Related Diffractive Imaging Methods , 2008 .

[28]  T. Latychevskaia,et al.  When holography meets coherent diffraction imaging. , 2011, Optics express.

[29]  J. Campbell Introduction to remote sensing , 1987 .

[30]  Vicente Durán,et al.  Compressive holography with a single-pixel detector. , 2013, Optics letters.

[31]  I. Yamaguchi,et al.  Phase-shifting digital holography. , 1997, Optics letters.

[32]  Ki-Nam Joo,et al.  High-speed combined NIR low-coherence interferometry for wafer metrology. , 2017, Applied optics.

[33]  J. Miao,et al.  Beyond crystallography: Diffractive imaging using coherent x-ray light sources , 2015, Science.

[34]  O. Bunk,et al.  Ptychographic X-ray computed tomography at the nanoscale , 2010, Nature.

[35]  J. Miao,et al.  Extending the methodology of X-ray crystallography to allow imaging of micrometre-sized non-crystalline specimens , 1999, Nature.

[36]  A. Greenaway,et al.  Alternative to Holography for Determining Phase from Image Intensity Measurements in Optics , 1974, Nature.

[37]  A Yariv,et al.  Amplified reflection, phase conjugation, and oscillation in degenerate four-wave mixing. , 1977, Optics letters.

[38]  Qionghai Dai,et al.  Single-pixel phase and fluorescence microscope. , 2018, Optics express.

[39]  Zhang Jiang,et al.  Three-dimensional coherent X-ray surface scattering imaging near total external reflection , 2012, Nature Photonics.

[40]  Robert W. Boyd,et al.  Imaging with a small number of photons , 2014, Nature Communications.

[41]  Keith A. Nugent,et al.  Coherent lensless X-ray imaging , 2010 .

[42]  Ting Sun,et al.  Single-pixel imaging via compressive sampling , 2008, IEEE Signal Process. Mag..

[43]  J. Goodman Introduction to Fourier optics , 1969 .

[44]  Ramachandra R. Dasari,et al.  Label-free route to rapid, nanoscale characterization of cellular structure and dynamics through opaque media , 2013, Scientific Reports.

[45]  C. Depeursinge,et al.  Quantitative phase imaging in biomedicine , 2012, 2012 Conference on Lasers and Electro-Optics (CLEO).

[46]  Kubilay Sertel,et al.  Phase-Sensitive Single-Pixel THz Imaging Using Intensity-Only Measurements , 2016, IEEE Transactions on Terahertz Science and Technology.

[47]  R. Horstmeyer,et al.  Wide-field, high-resolution Fourier ptychographic microscopy , 2013, Nature Photonics.

[48]  Ruifeng Liu,et al.  Complex wavefront reconstruction with single-pixel detector , 2019, Applied Physics Letters.