PET-MR Attenuation Correction in Dynamic Brain PET Using [11C]Cimbi-36: A Direct Comparison With PET-CT

PET-MR is increasingly used in a range of clinical indications, though its use for quantitative brain PET research has not been widely reported. To isolate and evaluate MR-based attenuation correction (MR-AC) effects on fitted PET kinetic model parameters, we used a previously reported atlas-based method to synthesize CTs from structural MR scans, substituted for the CTs acquired in a dynamic PET-CT study where [11C]Cimbi-36 was used to quantify 5-HT2A receptor binding in the brain. The resulting small differences (<5%) in kinetic outcome measures using MR-AC compared to CT-AC were consistent with the observed differences between the MR-AC and CT attenuation maps and within the test-retest variability of the radioligand. This supports the use of MR-AC for quantitative PET imaging of the brain.

[1]  E. Hoffman,et al.  TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD , 1980, Annals of neurology.

[2]  A. Lammertsma,et al.  Simplified Reference Tissue Model for PET Receptor Studies , 1996, NeuroImage.

[3]  Vincent J. Cunningham,et al.  Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model , 1997, NeuroImage.

[4]  M. Daube-Witherspoon,et al.  Quantitative functional brain imaging with positron emission tomography , 1998 .

[5]  A. Gjedde,et al.  Quantitative functional brain imaging with positron emission tomography , 1998 .

[6]  Michael Brady,et al.  Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images , 2002, NeuroImage.

[7]  N. Craddock,et al.  No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis , 2003, Acta psychiatrica Scandinavica.

[8]  L. Lam,et al.  5‐HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease , 2004, International journal of geriatric psychiatry.

[9]  Andrei G. Vlassenko,et al.  Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography , 2004, Biological Psychiatry.

[10]  E. Rabiner,et al.  PET studies in drug development: Methodological considerations. , 2005, Drug discovery today. Technologies.

[11]  Kris Thielemans,et al.  Correction of head movement on PET studies: comparison of methods. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[12]  D. Townsend,et al.  Method for transforming CT images for attenuation correction in PET/CT imaging. , 2006, Medical physics.

[13]  D. Louis Collins,et al.  Symmetric Atlasing and Model Based Segmentation: An Application to the Hippocampus in Older Adults , 2006, MICCAI.

[14]  K. Herholz,et al.  Brain receptor imaging. , 2010, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[15]  Kris Thielemans,et al.  Image-based correction for mismatched attenuation in PET images , 2008, 2008 IEEE Nuclear Science Symposium Conference Record.

[16]  Mark Jenkinson,et al.  Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy , 2011, NeuroImage.

[17]  C. Svarer,et al.  Serotonin 2A Receptor Agonist Binding in the Human Brain with [11C]Cimbi-36 , 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  Ninon Burgos,et al.  Attenuation Correction Synthesis for Hybrid PET-MR Scanners: Application to Brain Studies , 2014, IEEE Transactions on Medical Imaging.

[19]  Ninon Burgos,et al.  Multi-contrast attenuation map synthesis for PET/MR scanners: assessment on FDG and Florbetapir PET tracers , 2015, European Journal of Nuclear Medicine and Molecular Imaging.

[20]  G. Searle,et al.  The Simplified Reference Tissue Model: Model Assumption Violations and Their Impact on Binding Potential , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[21]  Claus Svarer,et al.  Serotonin 2A receptor agonist binding in the human brain with [11C]Cimbi-36: Test–retest reproducibility and head-to-head comparison with the antagonist [18F]altanserin , 2016, NeuroImage.

[22]  Ninon Burgos,et al.  A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients , 2016, NeuroImage.

[23]  N. Costes,et al.  Multi-atlas attenuation correction supports full quantification of static and dynamic brain PET data in PET-MR , 2017, Physics in medicine and biology.