Modeling Sequences of Regressions Distinguish Nonmechanical from Mechanical Associations between Metabolic Factors , Body Composition , and Bone in Healthy Postmenopausal Women 1 – 3

Background: There is increasing recognition of complex interrelations between the endocrine functions of bone and fat

[1]  P. Ebeling,et al.  Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. , 2014, Bone.

[2]  J. Kanis,et al.  Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden , 2014, Osteoporosis International.

[3]  L. Korányi,et al.  Serum osteocalcin is associated with improved metabolic state via adiponectin in females versus testosterone in males. Gender specific nature of the bone-energy homeostasis axis. , 2013, Bone.

[4]  M. Oudega,et al.  Aberrant Crossed Corticospinal Facilitation in Muscles Distant from a Spinal Cord Injury , 2013, PloS one.

[5]  C. Langefeld,et al.  Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. , 2013, The Journal of clinical endocrinology and metabolism.

[6]  Nanny Wermuth,et al.  Concepts and a case study for a flexible class of graphical Markov models , 2013, 1303.1436.

[7]  J. Kanis,et al.  High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  J. Cauley,et al.  The effects of adiponectin and leptin on changes in bone mineral density , 2012, Osteoporosis International.

[9]  K. Ward.  Musculoskeletal phenotype through the life course: the role of nutrition , 2011, Proceedings of the Nutrition Society.

[10]  K. Ng.  Regulation of glucose metabolism and the skeleton , 2011, Clinical endocrinology.

[11]  C. Combescure,et al.  Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. , 2011, The Journal of clinical endocrinology and metabolism.

[12]  J. Cauley,et al.  Adipokines and the risk of fracture in older adults , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[13]  T. Clemens,et al.  The osteoblast: An insulin target cell controlling glucose homeostasis , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  N. Wermuth,et al.  Sequences of regressions and their independences , 2011, 1110.1986.

[15]  L. Ferrucci,et al.  Adiponectin and bone mass density: The InCHIANTI study. , 2010, Bone.

[16]  I. Reid.  Fat and bone. , 2010, Archives of biochemistry and biophysics.

[17]  A. Schwartz,et al.  Bone and glucose metabolism: a two-way street. , 2010, Archives of biochemistry and biophysics.

[18]  N. Timpson,et al.  Adiponectin and its association with bone mass accrual in childhood , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[19]  I. Reid,et al.  In vitro and in vivo effects of adiponectin on bone. , 2009, Endocrinology.

[20]  P. Havel,et al.  Physiological, pharmacological, and nutritional regulation of circulating adiponectin concentrations in humans. , 2008, Metabolic syndrome and related disorders.

[21]  J. Jürimäe,et al.  Plasma adiponectin concentration in healthy pre- and postmenopausal women: relationship with body composition, bone mineral, and metabolic variables. , 2007, American journal of physiology. Endocrinology and metabolism.

[22]  Anthony C. Jones,et al.  Construction of the Femoral Neck During Growth Determines Its Strength in Old Age , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  T. Spector,et al.  Serum adiponectin and bone mineral density in women. , 2007, The Journal of clinical endocrinology and metabolism.

[24]  F. Rauch.  Bone Accrual in Children: Adding Substance to Surfaces , 2007, Pediatrics.

[25]  Kozo Nakamura,et al.  Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways , 2006, Journal of cellular biochemistry.

[26]  E. Barrett-Connor,et al.  Leptin Predicts BMD and Bone Resorption in Older Women but Not Older Men: The Rancho Bernardo Study , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[27]  J. Adams,et al.  Recommendations for Thresholds for Cortical Bone Geometry and Density Measurement by Peripheral Quantitative Computed Tomography , 2005, Calcified Tissue International.

[28]  C. Drevon,et al.  Adiponectin and its receptors are expressed in bone-forming cells. , 2004, Bone.

[29]  M. Shearer,et al.  Determination of phylloquinone (vitamin K1) in plasma and serum by HPLC with fluorescence detection. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[30]  S. Takeda,et al.  Serum leptin level is a regulator of bone mass. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[31]  H. Syddall,et al.  Plasma Leptin Concentration and Change in Bone Density Among Elderly Men and Women: The Hertfordshire Cohort Study , 2004, Calcified Tissue International.

[32]  S. Kihara,et al.  Obesity, adiponectin and vascular inflammatory disease , 2003, Current opinion in lipidology.

[33]  R. Vettor,et al.  Relationship between leptin levels and bone mineral density in the elderly , 2003, Clinical endocrinology.

[34]  R. Baumgartner,et al.  Serum leptin levels, bone mineral density and osteoblast alkaline phosphatase activity in elderly men and women , 2003, Mechanisms of Ageing and Development.

[35]  Graham J. Wills,et al.  Introduction to graphical modelling , 1995 .

[36]  L. Melton,et al.  Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. , 2001, Bone.

[37]  P. Laippala,et al.  Strong Prediction of Fractures Among Older Adults by the Ratio of Carboxylated to Total Serum Osteocalcin , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[38]  Arndt F Schilling,et al.  Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass , 2000, Cell.

[39]  B. Riggs,et al.  Immunoradiometric assay for intact human osteocalcin(1-49) without cross-reactivity to breakdown products. , 1999, Clinical chemistry.

[40]  M. Jensen,et al.  Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. , 1999, Endocrinology.

[41]  A. Goulding,et al.  Plasma Leptin Values in Relation to Bone Mass and Density and to Dynamic Biochemical Markers of Bone Resorption and Formation in Postmenopausal Women , 1998, Calcified Tissue International.

[42]  A. Boyde,et al.  Cancellous Bone Structure in the Growing and Aging Lumbar Spine in a Historic Nubian Population , 1997, Calcified Tissue International.

[43]  Nanny Wermuth,et al.  Multivariate Dependencies: Models, Analysis and Interpretation , 1996 .

[44]  P. Delmas,et al.  Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. , 1993, The Journal of clinical investigation.

[45]  W. Coward,et al.  Four-component model for the assessment of body composition in humans: comparison with alternative methods, and evaluation of the density and hydration of fat-free mass. , 1992, Clinical science.

[46]  H. Frost.  Bone “mass” and the “mechanostat”: A proposal , 1987, The Anatomical record.

[47]  B. McElmurry,et al.  The health of older women. , 1986, The Nursing clinics of North America.

[48]  S. Wright.  The Method of Path Coefficients , 1934 .

[49]  Jessika Weiss,et al.  Graphical Models In Applied Multivariate Statistics , 2016 .

[50]  Andreas Ritter,et al.  Structural Equations With Latent Variables , 2016 .

[51]  S. Booth,et al.  The role of osteocalcin in human glucose metabolism: marker or mediator? , 2013, Nature Reviews Endocrinology.

[52]  S de Bono,et al.  Could image analysis of pQCT scans provide additional information about bone strength? , 2008, Journal of musculoskeletal & neuronal interactions.

[53]  Mary L Bouxsein,et al.  Mechanisms of Disease: is osteoporosis the obesity of bone? , 2006, Nature Clinical Practice Rheumatology.

[54]  D. Reidpath,et al.  Near Normalisation of Lumbar Spine Bone Density in Young Women with Osteopenia Recovered from Adolescent Onset Anorexia Nervosa: A Longitudinal Study , 2005, Journal of pediatric endocrinology & metabolism : JPEM.

[55]  T. Cole,et al.  Sympercents: symmetric percentage differences on the 100 log(e) scale simplify the presentation of log transformed data. , 2002, Statistics in medicine.