Protein Sequence Variants: Resources and Tools

Originally published in: Biomedical Applications of Proteomics. Edited by Jean-Charles Sanchez, Garry L. Corthals and Denis F. Hochstrasser. Copyright © 2004 Wiley-VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3-527-30807-1 The sections in this article are Introduction Medical Protein Annotation Databases Central Databases Online Mendelian Inheritance in Man (OMIM) The Human Gene Mutation Database (HGMD) The SNP Databases Advantages and Drawbacks of Central Databases Specialized Databases An Example of a Locus-specific Database: the IARC TP53 Database An Example of a Disease-oriented Specialized Database: Retina International's Scientific Newsletter – Mutation Database Other Locus-specific Databases Advantages and Drawbacks of Specialized Databases The Swiss-Prot Protein Knowledgebase and Information on Disease and Sequence Variations Gene Names Description of Diseases Proteins as Therapeutic Drugs Data on Variants Cross-references Medical-oriented Keywords Techniques of Search Challenges for Databases Analysis Tools in the Context of Protein Variants Proteomic Tools for Protein Identification and the Characterization of Variants Protein Identification Tools Peptide Characterization Tools Tools for Analyzing and/or Predicting the Effects of Protein Variants Sequence-based Analysis or Prediction Tools Structure-based Analysis or Prediction Tools The Swiss-Prot Variant Page and Comparative Modeling Remarks Conclusions Keywords: protein variations; predicting the effects; resources; databases; techniques of search; analysis tools

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