Coronary and Basilar Artery Ectasia Are Associated: Results From an Autopsy Case–Control Study

Background and Purpose— Intracranial artery dolichoectasia (IADE) and coronary artery ectasia have been associated with stroke and myocardial infarction, respectively. Only rarely have cases of coexisting IADE and coronary artery ectasia been reported. We investigated this association in a large consecutive autopsy series. Methods— Sixteen stroke patients with IADE were identified among 381 stroke patients and were matched with 16 stroke patients without IADE. The heart and coronary arteries from all patients were examined after a prespecified protocol. Results— Coronary artery ectasia was observed in 8 of the stroke patients with IADE, and in none of the stroke patients without IADE (P=0.008). The diameters of basilar and right coronary arteries were positively correlated (IADE patients, r=0.51; P=0.003 and coronary artery ectasia patients, P=0.006). Conclusions— This autopsy study examining the association of coronary artery ectasia and IADE in stroke patients suggests a common pathogenesis.

[1]  Pierre Amarenco,et al.  Pathophysiology, presentation, prognosis, and management of intracranial arterial dolichoectasia , 2015, The Lancet Neurology.

[2]  Hideki Mochizuki,et al.  Basilar Artery Diameter Is an Independent Predictor of Incident Cardiovascular Events , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[3]  R. Swartz.  Moving vessel wall research beyond the plaque: basilar artery dilation as a window to systemic cardiovascular events. , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[4]  F. Cambien,et al.  Matrix metalloproteinase‐3 and intracranial arterial dolichoectasia , 2009, Annals of Neurology.

[5]  C. Duyckaerts,et al.  Association of Small-Vessel Disease With Dilatative Arteriopathy of the Brain: Neuropathologic Evidence , 2007, Stroke.

[6]  N. Lamblin,et al.  Prospective aortic screening in men with coronary aneurysms. , 2006, Journal of the American College of Cardiology.

[7]  P. Amarenco,et al.  Concurrent dolichoectasia of basilar and coronary arteries , 2005, Neurology.

[8]  O. Zaidat,et al.  Intracranial arterial dolichoectasia is associated with enlarged descending thoracic aorta , 2004, Neurology.

[9]  P. Amouyel,et al.  Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease. , 2002, Journal of the American College of Cardiology.

[10]  R. Simon,et al.  Exercise-induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“dilated coronaropathy”) , 1999 .

[11]  R. Meuli,et al.  The etiology of posterior circulation infarcts , 1993, Neurology.

[12]  C. Duyckaerts,et al.  The prevalence of ulcerated plaques in the aortic arch in patients with stroke. , 1992, The New England journal of medicine.

[13]  L. Fisher,et al.  Aneurysmal Coronary Artery Disease , 1983, Circulation.

[14]  Sacks Jg,et al.  Dolicho-ectatic intracranial arteries: symptomatology and pathogenesis of arterial elongation and distention. , 1969, The Johns Hopkins medical journal.