The mechanical properties of rat spinal cord in vitro.

Freshly excised rat spinal cords were tested in uniaxial tension, in vitro, at strain rates ranging from 0.002 to 0.2 s-1. Stress relaxation tests were performed for a range of strains from 2% to 5%, with the relaxation behaviour being recorded for a period of at least 30 min. Samples exhibited a characteristic "J" shaped non-linear stress-strain response, with stiffness increasing with applied strain. The cords were labelled with rows of small markers and the uniaxial tension tests were recorded via video. Subsequent image analysis enabled the distribution of strain on the cord surface to be determined. Viscoelastic models were developed to model the mechanical behaviour of the specimens and were found to adequately describe the material behaviour.

[1]  S. Woo,et al.  Stress relaxation of a peripheral nerve. , 1991, The Journal of hand surgery.

[2]  Y. Fung,et al.  Biorheology of soft tissues. , 1973, Biorheology.

[3]  L. Dougherty,et al.  In Vivo Human Cervical Spinal Cord Deformation and Displacement in Flexion , 1998, Spine.

[4]  T. Hung,et al.  Biomechanical and neurological response of the spinal cord of a puppy to uniaxial tension. , 1981, Journal of biomechanical engineering.

[5]  Lynne E. Bilston,et al.  The Effect of Perfusion on Soft Tissue Mechanical Properties: A Computational Model , 2002, Computer methods in biomechanics and biomedical engineering.

[6]  T. Hung,et al.  Stress-strain relationship and neurological sequelae of uniaxial elongation of the spinal cord of cats. , 1981, Surgical neurology.

[7]  T. G. Rogers,et al.  A non-linear integral representation for viscoelastic behaviour , 1968 .

[8]  W. W. Feng,et al.  An in-vivo measurement and analysis of viscoelastic properties of the spinal cord of cats. , 1988, Journal of biomechanical engineering.

[9]  T. Hung,et al.  Stress-strain relationship of the spinal cord of anesthetized cats. , 1981, Journal of biomechanics.

[10]  Y Lanir,et al.  Time-dependent mechanical behavior of sheep digital tendons, including the effects of preconditioning. , 2002, Journal of biomechanical engineering.

[11]  Alfred Reginald Allen,et al.  SURGERY OF EXPERIMENTAL LESION OF SPINAL CORD EQUIVALENT TO CRUSH INJURY OF FRACTURE DISLOCATION OF SPINAL COLUMN: A PRELIMINARY REPORT , 1911 .

[12]  S. Woo,et al.  Mechanical properties of tendons and ligaments. I. Quasi-static and nonlinear viscoelastic properties. , 1982, Biorheology.

[13]  T. Taguchi,et al.  Gray matter of the bovine cervical spinal cord is mechanically more rigid and fragile than the white matter. , 2001, Journal of neurotrauma.

[14]  A. Nachemson,et al.  Some mechanical properties of the third human lumbar interlaminar ligament (ligamentum flavum). , 1968, Journal of biomechanics.

[15]  A Viidik,et al.  A rheological model for uncalcified parallel-fibred collagenous tissue. , 1968, Journal of biomechanics.

[16]  J. Mcelhaney,et al.  A viscoelastic study of scalp, brain, and dura. , 1970, Journal of biomechanics.

[17]  M. Stoodley,et al.  Cerebrospinal fluid flow in an animal model of noncommunicating syringomyelia. , 1999, Neurosurgery.

[18]  J. Wrathall.  Spinal cord injury models. , 1992, Journal of neurotrauma.

[19]  A Viidik,et al.  Rheological analysis of soft collagenous tissue. Part I: theoretical considerations. , 1969, Journal of biomechanics.

[20]  Lynne E. Bilston,et al.  The mechanical properties of the human cervical spinal cordIn Vitro , 1995, Annals of Biomedical Engineering.

[21]  Y. Lanir.  The rheological behavior of the skin: experimental results and a structural model. , 1979, Biorheology.