Association of microwaves and ionizing radiation: potentiation of teratogenic effects in the rat.

Pregnant Wistar rats were exposed to either microwave-induced hyperthermia or gamma radiation or a combination of both. In microwave-induced hyperthermia, a core temperature of 42 degrees C was slightly teratogenic and a core temperature greater than or equal to 43 degrees C was highly teratogenic. Gamma radiation at 40 cGy was subteratogenic, while a dose of 75 cGy was highly teratogenic. A combination of microwave-induced hyperthermia up to 42 degrees C with 40 cGy of gamma radiation was highly teratogenic, indicating a mutual potentiation of the embryotoxic action of these two teratogens.

[1]  J. Lepock,et al.  Involvement of membranes in cellular responses to hyperthermia. , 1982, Radiation research.

[2]  W. James,et al.  HYPERTHERMIA AND MENINGOMYELOCELE AND ANENCEPHALY , 1978, The Lancet.

[3]  J. German.  Embryonic stress hypothesis of teratogenesis. , 1984, The American journal of medicine.

[4]  W. H. Nelson,et al.  American Environmental Mutagen Society Abstract of paper presented at the eighth annual meeting, 13 February–17 February, 1977, Colorado Springs (Colorado) (U.S.A.)Effects of chronic non-thermal exposures of pulsed microwaves on a repair-deficient mutant of Escherichia coli , 1978 .

[5]  F. Dietzel,et al.  [Abortion and deformities following short wave diathermy in pregnancy]. , 1966, Geburtshilfe und Frauenheilkunde.

[6]  D. Conover,et al.  Teratogenic effects of 27.12 MHz radiofrequency radiation in rats. , 1982, Teratology.

[7]  R D Blevins,et al.  The effects of microwave radiation and heat on specific mutants of Salmonella typhimurium LT2. , 1980, Radiation research.

[8]  J. Graham,et al.  Central nervous system and facial defects associated with maternal hyperthermia at four to 14 weeks' gestation. , 1981, Pediatrics.

[9]  James G. Wilson,et al.  EMBRYOLOGICAL CONSIDERATIONS IN TERATOLOGY * , 1965, Annals of the New York Academy of Sciences.

[10]  M. Edwards,et al.  Congenital malformations in the rat following induced hyperthermia during gestation. , 1968, Teratology.

[11]  D. Conover,et al.  Teratogenicity of 27.12-MHz radiation in rats is related to duration of hyperthermic exposure. , 1983, Bioelectromagnetics.

[12]  S. Clarren,et al.  Hyperthermia as a Possible Teratogenic Agent , 1978, The Journal of pediatrics.

[13]  R. Brent.  Radiations and Other Physical Agents , 1977 .

[14]  K. Shiota,et al.  Neural tube defects and maternal hyperthermia in early pregnancy: epidemiology in a human embryo population. , 1982, American journal of medical genetics.

[15]  M. Fahim,et al.  Enhancement of ionizing radiation effect on the testes of rats by microwave or ultrasound-induced hyperthermia. , 2009, Journal of medicine.

[16]  I. Leck.  MATERNAL HYPERTHERMIA AND ANENCEPHALY , 1978, The Lancet.

[17]  R. Mole.  Radiation effects on pre-natal development and their radiological significance. , 1979, The British journal of radiology.

[18]  W. STODOLNIK-BARAŃSKA.  Lymphoblastoid Transformation of Lymphocytes in vitro after Microwave Irradiation , 1967, Nature.

[19]  N. Škreb,et al.  Developmental abnormalities in the rat induced by heat shock. , 1963, Journal of embryology and experimental morphology.

[20]  S. Hume,et al.  The response of tissues to combined hyperthermia and X rays. , 1977, The British journal of radiology.

[21]  H. B. Carter,et al.  Observations of mouse fetuses after irradiation with 2.45 GHz microwaves. , 1978, Health physics.

[22]  A. Berteaud,et al.  An evaluation of the mutagenic, carcinogenic and teratogenic potential of microwaves. , 1983, Mutation research.

[23]  D. McRee,et al.  Teratogenic, biochemical, and histological studies with mice prenatally exposed to 2.45-GHz microwave radiation. , 1985, Radiation research.

[24]  S.M. Michaelson,et al.  Microwave biological effects: An overview , 1980, Proceedings of the IEEE.