Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

[1]  J. Kehrl,et al.  TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones , 2009, The Journal of experimental medicine.

[2]  Sue E. Poynter,et al.  Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4 , 2009, Respiratory research.

[3]  Michael Meyer-Hermann,et al.  Germinal centres seen through the mathematical eye: B-cell models on the catwalk. , 2009, Trends in immunology.

[4]  Arthur S Slutsky,et al.  Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury , 2008, Cell.

[5]  D. Hackam,et al.  The role of epithelial Toll‐like receptor signaling in the pathogenesis of intestinal inflammation , 2008, Journal of leukocyte biology.

[6]  T. Nakayama,et al.  Toll-like receptors in the respiratory system: Their roles in inflammation , 2008, Current allergy and asthma reports.

[7]  A. Best,et al.  Immune Complex-Bearing Follicular Dendritic Cells Deliver a Late Antigenic Signal That Promotes Somatic Hypermutation1 , 2008, The Journal of Immunology.

[8]  D. Rawlings,et al.  B cell–intrinsic TLR signals amplify but are not required for humoral immunity , 2007, The Journal of experimental medicine.

[9]  R. Ulevitch,et al.  TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock , 2007, The Journal of Immunology.

[10]  J. Tew,et al.  TLR4 on Follicular Dendritic Cells: An Activation Pathway That Promotes Accessory Activity1 , 2007, The Journal of Immunology.

[11]  Steve Gerondakis,et al.  Coordinating TLR‐activated signaling pathways in cells of the immune system , 2007, Immunology and cell biology.

[12]  M. Skobe,et al.  Lymphotoxin β receptor signaling is required for inflammatory lymphangiogenesis in the thyroid , 2007, Proceedings of the National Academy of Sciences.

[13]  A. Iwasaki,et al.  Innate control of adaptive immunity: dendritic cells and beyond. , 2007, Seminars in immunology.

[14]  A. Marshak‐Rothstein.  Toll-like receptors in systemic autoimmune disease , 2006, Nature Reviews Immunology.

[15]  D. Nemazee,et al.  Immunology: Toll-like receptors and antibody responses , 2006, Nature.

[16]  S. Akira,et al.  Pathogen Recognition and Innate Immunity , 2006, Cell.

[17]  Ruslan Medzhitov,et al.  Control of B-cell responses by Toll-like receptors , 2005, Nature.

[18]  F. Alt,et al.  The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation , 2005, Nature.

[19]  J. Tew,et al.  The Influence of Immune Complex-Bearing Follicular Dendritic Cells on the IgM Response, Ig Class Switching, and Production of High Affinity IgG1 , 2005, The Journal of Immunology.

[20]  Y. Choi,et al.  Follicular Dendritic Cells Produce IL-15 That Enhances Germinal Center B Cell Proliferation in Membrane-Bound Form1 , 2004, The Journal of Immunology.

[21]  J. Witztum,et al.  Oxidized low density lipoprotein and innate immune receptors , 2003, Current opinion in lipidology.

[22]  K. Toellner,et al.  Extrafollicular antibody responses , 2003, Immunological reviews.

[23]  M. Neuberger,et al.  Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase , 2002, Nature.

[24]  S. Akira,et al.  Toll-like receptors: critical proteins linking innate and acquired immunity , 2001, Nature Immunology.

[25]  A. Deutsch,et al.  Recycling probability and dynamical properties of germinal center reactions. , 2001, Journal of theoretical biology.

[26]  H. Husson,et al.  Functional Effects of TNF and Lymphotoxin α1β2 on FDC-like Cells , 2000 .

[27]  E. Dennis,et al.  Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[28]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[29]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[30]  C. Lawrence,et al.  Deoxycytidyl transferase activity of yeast REV1 protein , 1996, Nature.

[31]  R. Geha,et al.  Affinity maturation without germinal centres in lymphotoxin-α-deficient mice , 1996, Nature.

[32]  David D. Chaplin,et al.  Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers , 1996, Science.

[33]  H. Savelkoul,et al.  Suppression of polyclonal and antigen‐specific murine IgG1 but not IgE responses by neutralizing interleukin‐6 in vivo , 1994, European journal of immunology.

[34]  W. Newman,et al.  Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. , 1994, Journal of immunology.

[35]  J. Kwekkeboom,et al.  Direct evidence that human follicular dendritic cells (FDC) rescue germinal centre B cells from death by apoptosis , 1993, Clinical and experimental immunology.

[36]  D. Gray,et al.  Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. , 1992, Journal of immunology.

[37]  Klaus Rajewsky,et al.  Intraclonal generation of antibody mutants in germinal centres , 1991, Nature.

[38]  C. Meijer,et al.  Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways , 1991, The Journal of experimental medicine.

[39]  A Cumano,et al.  Evolutionary and somatic selection of the antibody repertoire in the mouse. , 1987, Science.

[40]  R. Phipps,et al.  Effect of immunosuppressive agents on antigen retained in lymphoid follicles and collagenous tissue of immune mice. , 1981, Cellular immunology.

[41]  Michael Meyer-Hermann,et al.  University of Birmingham Deriving a germinal center lymphocyte migration model from two-photon data , 2008 .

[42]  J. Humphrey,et al.  The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes on them , 1984, European journal of immunology.