The influence of semantic priming on event-related potentials to painful laser-heat stimuli in humans

In this study we investigated the effects of different semantic primes on the processing of painful stimuli. For prime stimuli, descriptors of three categories were used: somatosensory pain-related, affective pain-related, and neutral adjectives. While subjects (n=10) processed these primes, a painful laser-heat stimulus was applied. Laser-evoked potentials (LEPs) were recorded and pain intensity ratings were obtained after each single laser stimulus. Painful stimuli applied while subjects processed pain-related primes (affective and somatosensory adjectives) resulted in larger LEP amplitudes at 370 ms post laser stimulus compared to amplitudes of laser-evoked activities while subjects processed neutral primes (F((2,18))=3.90, P=0.05). It is suggested that pain-related semantic primes might preactivate neural networks subserving pain memory and pain processing. The processing of pain-related primes seems to preactivate cortical cell-assemblies involved in the processing of the succeeding painful laser stimuli.

[1]  R. Melzack.  The McGill Pain Questionnaire: Major properties and scoring methods , 1975, PAIN.

[2]  M. Rugg,et al.  Neural correlates of cued recall with and without retrieval of source memory , 1998, Neuroreport.

[3]  R. Treede,et al.  Laser-evoked potentials: exogenous and endogenous components. , 1996, Electroencephalography and clinical neurophysiology.

[4]  G. Bower.  Mood and memory. , 1981, The American psychologist.

[5]  P. Richardson,et al.  Memory and pain: tests of mood congruity and state dependent learning in experimentally induced and clinical pain , 1990, Pain.

[6]  Z. Segal,et al.  Mood priming and construct activation in tests of cognitive vulnerability to unipolar depression , 1994 .

[7]  R. Treede,et al.  Laser-evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients. , 1991, Revue neurologique.

[8]  V. Johnston,et al.  Multiple P3s to emotional stimuli and their theoretical significance. , 1986, Psychophysiology.

[9]  D. Yarnitsky,et al.  The P300 in pain evoked potentials , 1996, Pain.

[10]  P. Tueting,et al.  Event-related brain potentials in man , 1978 .

[11]  Thomas Weiss,et al.  A bioadaptive approach for experimental pain research in humans using laser-evoked brain potentials , 1997, Neuroscience Letters.

[12]  J. Spiegel,et al.  Laser-evoked potentials after painful hand and foot stimulation in humans: evidence for generation of the middle-latency component in the secondary somatosensory cortex , 1996, Neuroscience Letters.

[13]  E. Donchin,et al.  COGNITIVE PSYCHOPHYSIOLOGY: THE ENDOGENOUS COMPONENTS OF THE ERP , 1978 .

[14]  C. Braun,et al.  Somatosensory event-related potentials to painful and non-painful stimuli: effects of attention , 1989, Pain.

[15]  B. Bromm,et al.  Laser evoked brain potentials in response to painful trigeminal nerve activation. , 1995, The International journal of neuroscience.

[16]  W. Miltner,et al.  Reorganization of the somatosensory cortex after amputation of the index finger , 1998, Neuroreport.