Decision Activity in Parietal Cortex – Leader or Follower?

Katz and colleagues demonstrate that inactivating the primate lateral intraparietal area (LIP) spares visual motion decisions, even though these same decisions strongly modulate LIP neurons. This work is the latest addition to an intense effort spanning sensory modalities, animals, and techniques to understand which structures comprise the circuits responsible for interpreting sensory signals to make decisions.

[1]  Bingni W. Brunton,et al.  Cortical and Subcortical Contributions to Short-Term Memory for Orienting Movements , 2015, Neuron.

[2]  Matthew T. Kaufman,et al.  Posterior parietal cortex guides visual decisions in rats , 2016 .

[3]  Jacqueline Gottlieb,et al.  Functional Significance of Nonspatial Information in Monkey Lateral Intraparietal Area , 2009, The Journal of Neuroscience.

[4]  Zengcai V. Guo,et al.  A motor cortex circuit for motor planning and movement , 2015, Nature.

[5]  Bingni W. Brunton,et al.  Distinct effects of prefrontal and parietal cortex inactivations on an accumulation of evidence task in the rat , 2015, bioRxiv.

[6]  Jonathan W. Pillow,et al.  Dissociated functional significance of decision-related activity in the primate dorsal stream , 2016, Nature.

[7]  Yong Gu,et al.  Evidence for a Causal Contribution of Macaque Vestibular, But Not Intraparietal, Cortex to Heading Perception , 2016, The Journal of Neuroscience.

[8]  Matthew T. Kaufman,et al.  A category-free neural population supports evolving demands during decision-making , 2014, Nature Neuroscience.

[9]  Christopher D. Harvey,et al.  Choice-specific sequences in parietal cortex during a virtual-navigation decision task , 2012, Nature.

[10]  Roozbeh Kiani,et al.  Three challenges for connecting model to mechanism in decision-making , 2016, Current Opinion in Behavioral Sciences.

[11]  Roozbeh Kiani,et al.  A neural mechanism of speed-accuracy tradeoff in macaque area LIP , 2014, eLife.

[12]  M. Shadlen,et al.  Decision-making with multiple alternatives , 2008, Nature Neuroscience.