论文信息 - Diffuse gastrointestinal involvement of mantle cell lymphoma.

Diffuse gastrointestinal involvement of mantle cell lymphoma.

The gastrointestinal tract is the predominant site of appearance of extranodal non-Hodgkin lymphomas. The most frequent endoscopic finding of mantle cell lymphoma is multiple lymphomatous polyposis, which is a very rare entity. Multiple lymphomatous polyposis is characterized by multiple polypoid lesions involving long segments of the gastrointestinal tract and it accounts for 2% of primary gastrointestinal tract lymphomas. A 68-year-old patient was admitted to our clinic with intermittent diarrhea, weight loss, hematochezia and fatigue. Multiple lymphomatous polyposis was detected on the endoscopic evaluations. Gastrointestinal mantle cell lymphoma was confirmed with histopathological and immunohistochemical studies on biopsy specimens from colon, small intestine and stomach. The patient was successfully treated by combination chemotherapy.

[1] S. Tamura,et al. Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract , 2004, Journal of Gastroenterology.

[2] K. Okazaki. Multiple lymphomatous polyposis form is common but not specific for mantle cell lymphoma in the gastrointestinal tract , 2004, Journal of gastroenterology.

[3] N. Nakamura,et al. Multiple lymphomatous polyposis of the gastrointestinal tract is a heterogenous group that includes mantle cell lymphoma and follicular lymphoma: analysis of somatic mutation of immunoglobulin heavy chain gene variable region. , 1999, Human pathology.

[4] A. López-Guillermo,et al. Mantle cell lymphoma , 1998, Seminars in hematology.

[5] D. Weisenburger,et al. Mantle cell lymphoma-- an entity comes of age. , 1996, Blood.

[6] M. Amer,et al. Gastrointestinal lymphoma in adults: clinical features and management of 300 cases. , 1994, Gastroenterology.

[7] G. D. Scarrow,et al. Multiple lymphomatous polyposis of the gastro‐intestinal tract , 1970, The British journal of surgery.

[8] T. Molina,et al. Multiple lymphomatous polyposis of the gastrointestinal tract: prospective clinicopathologic study of 31 cases. Groupe D'étude des Lymphomes Digestifs. , 1997, Gastroenterology.