TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients

[1]  M. Relling,et al.  Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia , 2009, Clinical pharmacology and therapeutics.

[2]  J. Sanderson,et al.  Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease , 2008, Alimentary pharmacology & therapeutics.

[3]  V. Armstrong,et al.  Characterization of the Inosine Triphosphatase (ITPA) Gene: Haplotype Structure, Haplotype-Phenotype Correlation and Promoter Function , 2008, Therapeutic drug monitoring.

[4]  D. Svinarov,et al.  Analysis of ITPA Phenotype-Genotype Correlation in the Bulgarian Population Revealed a Novel Gene Variant in Exon 6 , 2007, Therapeutic drug monitoring.

[5]  M. Benninga,et al.  Pharmacogenetics of thiopurine therapy in paediatric IBD patients , 2006, Alimentary pharmacology & therapeutics.

[6]  D. Hommes,et al.  Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[7]  Shufeng Zhou Clinical pharmacogenomics of thiopurine S-methyltransferase. , 2006, Current clinical pharmacology.

[8]  V. Armstrong,et al.  Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study. , 2005, Clinical chemistry.

[9]  E. Kuipers,et al.  ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients. , 2005, Gut.

[10]  L. Domański,et al.  The Impact of Thiopurine S-Methyltransferase Polymorphism on Azathioprine-Induced Myelotoxicity in Renal Transplant Recipients , 2005, Therapeutic drug monitoring.

[11]  C. Libersa,et al.  ITPA genotyping test does not improve detection of Crohn’s disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression , 2005, Gut.

[12]  R. Gearry,et al.  Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine. , 2004, Pharmacogenetics.

[13]  M. Droździk,et al.  Frequency Distribution of Thiopurine S-Methyltransferase Alleles in a Polish Population , 2004, Therapeutic drug monitoring.

[14]  Des C. Jones,et al.  The impact of thiopurine S-methyltransferase polymorphisms on azathioprine dose 1 year after renal transplantation , 2004, Transplant international : official journal of the European Society for Organ Transplantation.

[15]  C. Lewis,et al.  Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). , 2004, Pharmacogenetics.

[16]  J. Sanderson,et al.  Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency , 2002, Human Genetics.

[17]  H. McLeod,et al.  The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics. , 2002, Pharmacogenomics.

[18]  M. Relling,et al.  Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  C. Kirkpatrick,et al.  Genetic polymorphism and outcomes with azathioprine and 6-mercaptopurine. , 2000, Adverse drug reactions and toxicological reviews.

[20]  M. Relling,et al.  Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. , 1996, Pharmacogenetics.

[21]  J. Lilleyman,et al.  Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. , 1993, Archives of disease in childhood.

[22]  R. Weinshilboum,et al.  Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. , 1980, American journal of human genetics.