In vivo chemical exchange saturation transfer imaging of creatine (CrCEST) in skeletal muscle at 3T

To characterize the chemical exchange saturation transfer (CEST)‐based technique to measure free creatine (Cr), a key component of muscle energy metabolism, distribution in skeletal muscle with high spatial resolution before and after exercise at 3T.

[1]  Peter C M van Zijl,et al.  High-throughput screening of chemical exchange saturation transfer MR contrast agents. , 2010, Contrast media & molecular imaging.

[2]  Ravinder Reddy,et al.  Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI , 2012, NMR in biomedicine.

[3]  Ravinder Reddy,et al.  Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer , 2014, Magnetic resonance in medicine.

[4]  T. Parrish,et al.  A new T2 preparation technique for ultrafast gradient‐echo sequence , 1994, Magnetic resonance in medicine.

[5]  T. Inubushi,et al.  Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopy. , 1995, Circulation.

[6]  R S Balaban,et al.  Detection of proton chemical exchange between metabolites and water in biological tissues. , 1998, Journal of magnetic resonance.

[7]  S. Ward,et al.  Dynamics of intramuscular 31P-MRS P(i) peak splitting and the slow components of PCr and O2 uptake during exercise. , 2002, Journal of applied physiology.

[8]  P A Bottomley,et al.  Total creatine in muscle: imaging and quantification with proton MR spectroscopy. , 1997, Radiology.

[9]  Jinyuan Zhou,et al.  Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments , 2004, Magnetic resonance in medicine.

[10]  Ravinder Reddy,et al.  On B1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T , 2013, Magnetic resonance in medicine.

[11]  M. Tarnopolsky,et al.  Direct measurement of high‐energy phosphate compounds in patients with neuromuscular disease , 1999, Muscle & nerve.

[12]  R S Balaban,et al.  Imaging of urea using chemical exchange‐dependent saturation transfer at 1.5T , 2000, Journal of magnetic resonance imaging : JMRI.

[13]  B CHANCE,et al.  Respiratory enzymes in oxidative phosphorylation. III. The steady state. , 1955, The Journal of biological chemistry.

[14]  B. Chance.  ENZYMES IN OXIDATIVE PHOSPHORYLATION , 2003 .

[15]  Bennett A Landman,et al.  Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments , 2009, Magnetic resonance in medicine.

[16]  D. I. Hoult,et al.  Observation of tissue metabolites using 31P nuclear magnetic resonance , 1974, Nature.

[17]  Manojkumar Saranathan,et al.  Musculoskeletal MRI at 3.0 T and 7.0 T: a comparison of relaxation times and image contrast. , 2013, European journal of radiology.

[18]  D. Arnold,et al.  Insights into muscle diseases gained by phosphorus magnetic resonance spectroscopy , 2000, Muscle & nerve.

[19]  R S Balaban,et al.  A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). , 2000, Journal of magnetic resonance.

[20]  Thomas Benner,et al.  Investigation of optimizing and translating pH‐sensitive pulsed‐chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner , 2008, Magnetic resonance in medicine.

[21]  Jinyuan Zhou,et al.  Amide proton transfer (APT) contrast for imaging of brain tumors , 2003, Magnetic resonance in medicine.

[22]  R. Davies,et al.  A Molecular Theory of Muscle Contraction : Calcium-Dependent Contractions with Hydrogen Bond Formation Plus ATP-Dependent Extensions of Part of the Myosin-Actin Cross-Bridges , 1963, Nature.

[23]  Ravinder Reddy,et al.  Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications , 2013, Current Radiology Reports.

[24]  Ewald Moser,et al.  Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review , 2007, NMR in biomedicine.