Optimizing the performance of magnetic-assisted capsule endoscopy of the upper GI tract using multiplanar CT modelling

Background and aims This study used computed tomography modelling of the abdomen to determine the optimal placements of a magnetic capsule endoscope in the stomach that allows complete mucosal visualization and determined the optimal placement of the handheld magnet to aid pyloric traversing. Materials and methods Using multiplanar reformatting, 100 abdominal computed tomography scans were analysed to assess gastric luminal visualization by a capsule endoscope from five fixed stations throughout the stomach. From each station, we assessed the ability of a capsule endoscope to visualize six gastric landmarks. The pyloric canal angles were calculated to create a vector. We mapped the position of this vector on the patient to determine the optimal placement of the magnet that would aid pyloric traversing. Results Complete visualization of the stomach (viewing all landmarks) was only achievable in up to 29% of cases when viewed from a sole station. Maximal visualization required combining stations. Fundal dependent (station 1) and opposite antral dependent (station 4) was the best, achieving visualization in 85% (P<0.01). The optimal positioning of the magnet to aid pyloric traversing was posteriorly between vertebrae T5 and L2 in an area 10 cm to the left and 18 cm to the right (83% cases). Age older than 55 years (P=0.03) and the ability to view the pylorus from station 3 (P=0.04) were associated with an extreme pyloric vector. Conclusion Although there is some extreme variation in the upper gastrointestinal anatomy, the majority of cases will allow the use of a single standard method in performing MACE, which may be very useful for screening purposes.

[1]  Moshe Rubin,et al.  Pillcam ESO® is more accurate than clinical scoring systems in risk stratifying emergency room patients with acute upper gastrointestinal bleeding , 2013, Therapeutic advances in gastroenterology.

[2]  J. Aparicio,et al.  Right lateral position does not affect gastric transit times of video capsule endoscopy: a prospective study. , 2009, Gastrointestinal endoscopy.

[3]  M Takahashi,et al.  CT evaluation of gastric lesions with three-dimensional display and interactive virtual endoscopy: comparison with conventional barium study and endoscopy. , 1999, AJR. American journal of roentgenology.

[4]  R. Mohan,et al.  Quantifying the interfractional displacement of the gastroesophageal junction during radiation therapy for esophageal cancer. , 2012, International journal of radiation oncology, biology, physics.

[5]  W. Ahmed,et al.  Normal oesophageal manometric values in healthy adult volunteers. , 2003, JPMA. The Journal of the Pakistan Medical Association.

[6]  Christoph F. Dietrich,et al.  Wie sicher ist die Sedierung in der gastrointestinalen Endoskopie? Eine multizentrische Auswertung von 388 404 Endoskopien und Auswertung der Daten aus prospektiv geführten Komplikationsregistern von Mitgliedern der Arbeitsgemeinschaft leitender Gastroenterologen im Krankenhaus (ALGK) , 2013, Zeitschrift für Gastroenterologie.

[7]  P. Swain,et al.  Inspection of the human stomach using remote-controlled capsule endoscopy: a feasibility study in healthy volunteers (with videos). , 2011, Gastrointestinal endoscopy.

[8]  E. Fishman,et al.  CT of the stomach: spectrum of disease. , 1996, Radiographics : a review publication of the Radiological Society of North America, Inc.

[9]  A. Hila,et al.  Normal values for manometry performed with swallows of viscous test material , 2008, Scandinavian journal of gastroenterology.

[10]  Konstantinos Triantafyllou,et al.  Colon capsule endoscopy is feasible to perform after incomplete colonoscopy and guides further workup in clinical practice. , 2014, Gastrointestinal endoscopy.

[11]  M. Crowell,et al.  A national study of cardiopulmonary unplanned events after GI endoscopy. , 2007, Gastrointestinal endoscopy.

[12]  Guido Costamagna,et al.  Second-generation colon capsule endoscopy compared with colonoscopy. , 2011, Gastrointestinal endoscopy.

[13]  Anne M.R. Agur,et al.  Grant's Atlas of Anatomy , 1943 .

[14]  R. Sidhu,et al.  PTU-034 Double Blind Randomised Controlled Trial Of Magnetically Steerable Gastric Capsule Endoscopy (msgce) Vs. Conventional Gastroscopy For Detection Of Beads In A Porcine Stomach , 2014, Gut.

[15]  Federico Carpi,et al.  Magnetic shells for gastrointestinal endoscopic capsules as a means to control their motion. , 2006, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[16]  S. Kudo,et al.  Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard videoendoscope. , 2012, Gastrointestinal endoscopy.

[17]  Jae Young Lee,et al.  Gastrointestinal stromal tumor of the stomach: preliminary results of preoperative evaluation with CT gastrography , 2008, Abdominal Imaging.

[18]  Y. Kuo,et al.  Capsule endoscopy with PILLCAM ESO for detecting esophageal varices: a meta-analysis. , 2011, Minerva gastroenterologica e dietologica.

[19]  A. Wu,et al.  Normal oesophageal manometric values in healthy adult volunteers. , 2003 .

[20]  Hisao Ito,et al.  Intrafractional gastric motion and interfractional stomach deformity using CT images. , 2011, Journal of Radiation Research.

[21]  June A. Castell,et al.  Esophageal manometry in 95 healthy adult volunteers , 1987, Digestive Diseases and Sciences.

[22]  P J Kahrilas,et al.  Esophageal peristaltic dysfunction in peptic esophagitis. , 1986, Gastroenterology.

[23]  Geoffrey H. Sperber,et al.  Clinically Oriented Anatomy , 2006 .