Dendritic spines are lost in clusters in Alzheimer’s disease

[1]  M. Sabbagh,et al.  Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval , 2020, Alzheimer's Research & Therapy.

[2]  F. Edwards A Unifying Hypothesis for Alzheimer’s Disease: From Plaques to Neurodegeneration , 2019, Trends in Neurosciences.

[3]  Guy Eyal,et al.  Human Cortical Pyramidal Neurons: From Spines to Spikes via Models , 2018, bioRxiv.

[4]  T. Hortobágyi,et al.  Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach , 2018, Brain : a journal of neurology.

[5]  Alcino J. Silva,et al.  Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory , 2018, Nature Communications.

[6]  Teresa J. Feo,et al.  Structural absorption by barbule microstructures of super black bird of paradise feathers , 2018, Nature Communications.

[7]  F. LaFerla,et al.  Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony , 2017, Trends in Neurosciences.

[8]  Daniel J. Whitcomb,et al.  Physiological and Pathophysiological Implications of Synaptic Tau , 2017, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[9]  Y. Zuo,et al.  Clustered structural and functional plasticity of dendritic spines , 2017, Brain Research Bulletin.

[10]  T. Arendt,et al.  Tau and tauopathies , 2016, Brain Research Bulletin.

[11]  A. Simmons,et al.  Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease , 2016, Cerebral cortex.

[12]  L. Schneider,et al.  Defeating Alzheimer's disease and other dementias: a priority for European science and society , 2016, The Lancet Neurology.

[13]  E. Mandelkow,et al.  Tau in physiology and pathology , 2015, Nature Reviews Neuroscience.

[14]  Se Jin Park,et al.  Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD , 2015, The Journal of Neuroscience.

[15]  Javier DeFelipe,et al.  The dendritic spine story: an intriguing process of discovery , 2015, Front. Neuroanat..

[16]  Alcino J. Silva,et al.  Synaptic clustering within dendrites: An emerging theory of memory formation , 2015, Progress in Neurobiology.

[17]  D. Liao,et al.  Tau acts as a mediator for Alzheimer's disease‐related synaptic deficits , 2014, The European journal of neuroscience.

[18]  E. Kandel,et al.  The Molecular and Systems Biology of Memory , 2014, Cell.

[19]  W. Noble,et al.  A role for tau at the synapse in Alzheimer's disease pathogenesis , 2014, Neuropharmacology.

[20]  G. Collingridge,et al.  Microtubule-associated protein tau is essential for long-term depression in the hippocampus , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[21]  Rafael Yuste,et al.  Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions. , 2013, Cerebral cortex.

[22]  Christine Haberler,et al.  Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series , 2013, Acta Neuropathologica.

[23]  J. DeFelipe,et al.  The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer’s disease , 2013, Brain : a journal of neurology.

[24]  J. DeFelipe,et al.  Tau Phosphorylation by GSK3 in Different Conditions , 2012, International journal of Alzheimer's disease.

[25]  Christian Lohmann,et al.  Synaptic clustering during development and learning: the why, when, and how , 2012, Front. Mol. Neurosci..

[26]  Ju Lu,et al.  REPETITIVE MOTOR LEARNING INDUCES COORDINATED FORMATION OF CLUSTERED DENDRITIC SPINES IN VIVO , 2012, Nature.

[27]  M. Häusser,et al.  Synaptic Integration Gradients in Single Cortical Pyramidal Cell Dendrites , 2011, Neuron.

[28]  Edward T. Bullmore,et al.  Modular and Hierarchically Modular Organization of Brain Networks , 2010, Front. Neurosci..

[29]  R. Yuste Dendritic Spines , 2010 .

[30]  J. DeFelipe,et al.  Pericellular Innervation of Neurons Expressing Abnormally Hyperphosphorylated Tau in the Hippocampal Formation of Alzheimer's Disease Patients , 2010, Front. Neuroanat..

[31]  Xenophon Papademetris,et al.  Graph-theory based parcellation of functional subunits in the brain from resting-state fMRI data , 2010, NeuroImage.

[32]  Dmitri B Chklovskii,et al.  Maximization of the connectivity repertoire as a statistical principle governing the shapes of dendritic arbors , 2009, Proceedings of the National Academy of Sciences.

[33]  I Ferrer,et al.  Widespread changes in dendritic spines in a model of Alzheimer's disease. , 2009, Cerebral cortex.

[34]  Alan C. Evans,et al.  Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease , 2008, The Journal of Neuroscience.

[35]  Jean-Loup Guillaume,et al.  Fast unfolding of communities in large networks , 2008, 0803.0476.

[36]  N. Spruston Pyramidal neurons: dendritic structure and synaptic integration , 2008, Nature Reviews Neuroscience.

[37]  Rafael Yuste,et al.  Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies , 2007, Front. Neurosci..

[38]  S. Tonegawa,et al.  A clustered plasticity model of long-term memory engrams , 2006, Nature Reviews Neuroscience.

[39]  P. T. Nguyen,et al.  Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy , 2005, The Journal of Neuroscience.

[40]  Jaime Grutzendler,et al.  Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches , 2004, Nature Neuroscience.

[41]  H. Braak,et al.  Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections , 1991, Brain pathology.

[42]  H. Wiśniewski,et al.  Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Gloria Lee,et al.  Tau and tauopathies. , 2012, Progress in molecular biology and translational science.

[44]  Judith G Giri,et al.  2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories. , 2012, Biopreservation and biobanking.

[45]  V. Murthy,et al.  Dendritic spines , 1998 .