Analyze and Determine the Forces Associated with the Nanoparticle Movement

The primary research objective of this paper is to analyze and determine the forces associated with the nanoparticle movement for use in in-vivo drug delivery by considering the fundamental physical and bio-mechanical principles. It requires a thorough study and understanding of the complex inter-relationships of the forces created from interactions among different nanoparticles, cells, and the biological environment. Lab-on-chip for nanoparticle drug delivery are the two innovative concepts that have evolved from recent investigations in the area of micro/nanosciences and technology. Lab-on-chip allow in-vitro research to be tested before, invivo techniques are applied. These studies will lay the foundation for future use in drug targeting to the diseased site or organ using externally applied forces. 1. Background

[1]  H. Bryant,et al.  A biomagnetic system for in vivo cancer imaging , 2005, Physics in medicine and biology.

[2]  Rong Wang,et al.  Protein delivery with nanoscale precision , 2005 .

[3]  M. Brightman,et al.  The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. II. Parenchymal distribution. , 1965, The American journal of anatomy.

[4]  John C. Bischof,et al.  In vitro characterization of movement, heating and visualization of magnetic nanoparticles for biomedical applications , 2005 .

[5]  Charles R. Meyer,et al.  Demonstration of accuracy and clinical versatility of mutual information for automatic multimodality image fusion using affine and thin-plate spline warped geometric deformations , 1997, Medical Image Anal..

[6]  Metin Sitti,et al.  Teleoperated touch feedback from the surfaces at the nanoscale: modeling and experiments , 2003 .

[7]  Gabriel A Silva,et al.  Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier. , 2007, Surgical neurology.

[8]  Bernhard Gleich,et al.  Targeted delivery of magnetic aerosol droplets to the lung , 2007, Nature Nanotechnology.

[9]  Raoul Kopelman,et al.  Brain cancer diagnosis and therapy with nanoplatforms. , 2006, Advanced drug delivery reviews.

[10]  Pavel Ikonomov,et al.  Virtual Reality approach for nanoparticles tracking using simulated forces , 2006 .

[11]  Daniel Horák,et al.  Size-dependent magnetic properties of iron oxide nanoparticles , 2016 .

[12]  Byungkyu Kim,et al.  Modeling and Simulation of Nanorobotic Manipulation with an AFM probe , 2002 .

[13]  Krishna C. Bhavaraju Interactive Virtual Reality Simulation for Nanoparticle Manipulation and Nanoassembly using Optical Tweezers , 2009, 2009 IEEE Virtual Reality Conference.

[14]  S. Kode,et al.  Simulation of Virtual Nanoparticle tracking using calculated forces for an Atomic Force Microscope and Optical Tweezers , 2007 .

[15]  Raoul Kopelman,et al.  Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors , 2006, Clinical Cancer Research.

[16]  Y. Sugii,et al.  Measurement of a Velocity Field in Microvessels Using a High Resolution PIV Technique , 2002, Annals of the New York Academy of Sciences.

[17]  A. Curtis,et al.  Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. , 2003, Biomaterials.

[18]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[19]  C Alexiou,et al.  Clinical applications of magnetic drug targeting. , 2001, The Journal of surgical research.

[20]  J. King,et al.  Drug delivery by magnetic microspheres , 2000 .

[21]  Taegyun Kim,et al.  Reduced magnetization in magnetic oxide nanoparticles , 2007 .

[22]  A. Pries,et al.  Biophysical aspects of blood flow in the microvasculature. , 1996, Cardiovascular research.

[23]  H. Hashimoto,et al.  Controlled pushing of nanoparticles: modeling and experiments , 2000 .

[24]  Ralph Weissleder,et al.  Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. , 2003, Journal of the American Chemical Society.

[25]  J. Gallo,et al.  Targeting Magnetic Microspheres to Brain Tumors , 1997 .

[26]  Giles Richardson,et al.  Mathematical modelling of magnetically targeted drug delivery , 2005 .

[27]  J. Dobson Magnetic nanoparticles for drug delivery , 2006 .

[28]  Pavel Ikonomov,et al.  Virtual Assembly/Disassembly System Using Natural Human Interaction and Control , 2004 .

[29]  A. P. Proshin,et al.  Mathematical modeling of blood circulation system and its practical application , 2006 .

[30]  E. Edelman,et al.  Physiological Transport Forces Govern Drug Distribution for Stent-Based Delivery , 2001, Circulation.

[31]  S. Nie,et al.  Therapeutic Nanoparticles for Drug Delivery in Cancer Types of Nanoparticles Used as Drug Delivery Systems , 2022 .

[32]  Milan Timko,et al.  Magnetic targeted drug delivery using focused magnet , 2004 .

[33]  I. V. Melemuka,et al.  Axial-flow micropumped system for assisted circulation , 1994 .