The role of hemoglobin in nitric oxide transport in vascular system

[1]  M. Perutz,et al.  Hemoglobin structure and respiratory transport. , 1978, Scientific American.

[2]  M. Doyle,et al.  Oxidation of nitrogen oxides by bound dioxygen in hemoproteins. , 1981, Journal of inorganic biochemistry.

[3]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[4]  H. Mizukami,et al.  Reaction of nitric oxide with heme proteins and model compounds of hemoglobin. , 1987, Biochemistry.

[5]  L. Ignarro,et al.  Endothelium‐Derived Relaxing Factor From Pulmonary Artery and Vein Possesses Pharmacologic and Chemical Properties Identical to Those of Nitric Oxide Radical , 1987, Circulation research.

[6]  P. Lane.  Sickle cell disease. , 1996, Pediatric clinics of North America.

[7]  J. R. Lancaster,et al.  Quantitation of nitrate and nitrite in extracellular fluids. , 1996, Methods in enzymology.

[8]  J. Stamler,et al.  S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control , 1996, Nature.

[9]  J. Olson,et al.  Mechanism of NO-induced oxidation of myoglobin and hemoglobin. , 1996, Biochemistry.

[10]  A. Seiyama,et al.  Physiological role of nitric oxide as an enhancer of oxygen transfer from erythrocytes to tissues. , 1996, Biochemical and biophysical research communications.

[11]  E. Camporesi,et al.  Half-life of nitric oxide in aqueous solutions with and without haemoglobin , 1996, Physiological measurement.

[12]  K. Phillips,et al.  The crystal structure of horse deoxyhaemoglobin trapped in the high-affinity (R) state. , 1996, Journal of molecular biology.

[13]  J. Liao,et al.  Intravascular flow decreases erythrocyte consumption of nitric oxide. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[14]  M. Gladwin,et al.  Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[15]  S. Herold,et al.  Kinetic and mechanistic studies of the NO*-mediated oxidation of oxymyoglobin and oxyhemoglobin. , 2001, Biochemistry.

[16]  Santiago Lamas,et al.  Nitrosylation The Prototypic Redox-Based Signaling Mechanism , 2001, Cell.

[17]  A. Popel,et al.  Erythrocyte consumption of nitric oxide in presence and absence of plasma-based hemoglobin. , 2002, American journal of physiology. Heart and circulatory physiology.

[18]  M. Gladwin,et al.  Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease , 2002, Nature Medicine.

[19]  M. Gladwin,et al.  Effects of Iron Nitrosylation on Sickle Cell Hemoglobin Solubility* , 2002, The Journal of Biological Chemistry.

[20]  M. Gladwin,et al.  Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation , 2003, Nature Medicine.

[21]  D. Green,et al.  Exercise and the Nitric Oxide Vasodilator System , 2003, Sports medicine.

[22]  R. Nagel,et al.  Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. , 2004, The Journal of clinical investigation.

[23]  G. Koren,et al.  Systemic Exposure to Morphine and the Risk of Acute Chest Syndrome in Sickle Cell Disease , 2003, Clinical pharmacology and therapeutics.

[24]  M. Gladwin,et al.  The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation. , 2005, Journal of inorganic biochemistry.

[25]  J. Lancaster,et al.  Hemoglobin-mediated, hypoxia-induced vasodilation via nitric oxide: mechanism(s) and physiologic versus pathophysiologic relevance. , 2005, American journal of respiratory cell and molecular biology.

[26]  M. Gladwin,et al.  Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. , 2005, The Journal of clinical investigation.

[27]  J. Liao,et al.  Erythrocyte nitric oxide transport reduced by a submembrane cytoskeletal barrier. , 2005, Biochimica et biophysica acta.

[28]  David J Singel,et al.  Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin. , 2005, Annual review of physiology.

[29]  T. McMahon,et al.  Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Martin Feelisch,et al.  Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues , 2005, Nature chemical biology.

[31]  M. Gladwin,et al.  Nitric Oxide Scavenging by Red Blood Cells as a Function of Hematocrit and Oxygenation* , 2005, Journal of Biological Chemistry.

[32]  M. Gladwin,et al.  Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. , 2005, The Journal of clinical investigation.

[33]  S. Peddada,et al.  Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis. , 2006, Thrombosis research.

[34]  M. Gladwin,et al.  Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. , 2006, American journal of physiology. Heart and circulatory physiology.

[35]  H. Ghofrani,et al.  Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond , 2006, Nature Reviews Drug Discovery.

[36]  M. Gladwin,et al.  Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin. , 2007, Blood.

[37]  B. Pipy,et al.  Microparticles from apoptotic monocytes induce transient platelet recruitment and tissue factor expression by cultured human vascular endothelial cells via a redox-sensitive mechanism , 2007, Thrombosis and Haemostasis.

[38]  I. Kosmidou,et al.  Statin Treatment and 3′ Polyadenylation of eNOS mRNA , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[39]  Zhi Huang,et al.  Nitric oxide red blood cell membrane permeability at high and low oxygen tension. , 2007, Nitric oxide : biology and chemistry.

[40]  M. Gladwin,et al.  Concerted Nitric Oxide Formation and Release from the Simultaneous Reactions of Nitrite with Deoxy- and Oxyhemoglobin* , 2007, Journal of Biological Chemistry.

[41]  M. Gladwin,et al.  Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. , 2007, Nature chemical biology.

[42]  S. Takeoka,et al.  Encapsulation of Concentrated Hemoglobin Solution in Phospholipid Vesicles Retards the Reaction with NO, but Not CO, by Intracellular Diffusion Barrier* , 2008, Journal of Biological Chemistry.

[43]  Aleksander S Popel,et al.  Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. , 2008, Antioxidants & redox signaling.

[44]  Mark T. Gladwin,et al.  The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics , 2008, Nature Reviews Drug Discovery.

[45]  Mark T Gladwin,et al.  The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase. , 2009, Accounts of chemical research.

[46]  M. Gladwin,et al.  Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions , 2009, American journal of hematology.

[47]  B. Isakson,et al.  The Myoendothelial Junction: Breaking through the Matrix? , 2009, Microcirculation.

[48]  Xiaoping Liu,et al.  Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall. , 2010, Nitric oxide : biology and chemistry.

[49]  M. Kavdia,et al.  Extracellular diffusion and permeability effects on NO-RBCs interactions using an experimental and theoretical model. , 2010, Microvascular research.

[50]  O. Platt,et al.  Pulmonary hypertension and nitric oxide depletion in sickle cell disease. , 2010, Blood.

[51]  M. L. Ellsworth,et al.  Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. , 2010, American journal of physiology. Heart and circulatory physiology.

[52]  A. Levy,et al.  Haptoglobin: basic and clinical aspects. , 2010, Antioxidants & redox signaling.

[53]  W. Yin,et al.  Complement activation on platelets: implications for vascular inflammation and thrombosis. , 2010, Molecular immunology.

[54]  M. Gladwin,et al.  Effect of eculizumab on haemolysis‐associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria , 2010, British journal of haematology.

[55]  O. Baskurt,et al.  Nitric oxide generation in red blood cells induced by mechanical stress. , 2010, Clinical hemorheology and microcirculation.

[56]  Janet S. Lee,et al.  Mechanisms of Slower Nitric Oxide Uptake by Red Blood Cells and Other Hemoglobin-containing Vesicles* , 2011, The Journal of Biological Chemistry.

[57]  M. Gladwin.  Nitric oxide scavenging by red cell microparticles and cell free hemoglobin as a mechanism for hemolytic diseases and the red blood cell storage lesion , 2011, BMC Pharmacology.

[58]  M. Gladwin,et al.  The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals , 2011 .

[59]  A. Palmer,et al.  Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling. , 2011, Nitric oxide : biology and chemistry.

[60]  M. Gladwin,et al.  Hemoglobin as a nitrite anhydrase: modeling methemoglobin-mediated N2O3 formation. , 2011, Chemistry.

[61]  R. Touyz,et al.  Microparticles Induce Cell Cycle Arrest Through Redox-Sensitive Processes in Endothelial Cells: Implications in Vascular Senescence , 2012, Journal of the American Heart Association.

[62]  Y. Daaka.  S-nitrosylation-regulated GPCR signaling. , 2012, Biochimica et biophysica acta.

[63]  A. Lumb,et al.  Physiology of haemoglobin , 2012 .

[64]  A. Risitano,et al.  Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders. , 2012, Immunobiology.

[65]  U. Förstermann,et al.  Nitric oxide synthases: regulation and function. , 2012, European heart journal.

[66]  Mark T. Gladwin,et al.  Vascular biology: Nitric oxide caught in traffic , 2012, Nature.

[67]  G. Kato.  Priapism in sickle-cell disease: a hematologist's perspective. , 2012, The journal of sexual medicine.

[68]  B. Owusu,et al.  Nitric oxide formation versus scavenging: the red blood cell balancing act , 2012, The Journal of physiology.

[69]  M. Thevis,et al.  RBC-NOS-Dependent S-Nitrosylation of Cytoskeletal Proteins Improves RBC Deformability , 2013, PloS one.

[70]  M. Kavdia,et al.  Contribution of membrane permeability and unstirred layer diffusion to nitric oxide-red blood cell interaction. , 2013, Journal of theoretical biology.

[71]  M. Gladwin,et al.  Nitric oxide scavenging by red cell microparticles. , 2013, Free radical biology & medicine.

[72]  F. Vinchi,et al.  Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction: Scavenging Free Heme to Preserve Vasculature Homeostasis , 2013, Oxidative medicine and cellular longevity.

[73]  Daniel B Kim-Shapiro,et al.  Hemoglobin-mediated nitric oxide signaling. , 2013, Free radical biology & medicine.

[74]  P. Kadowitz,et al.  Updated role of nitric oxide in disorders of erythrocyte function. , 2013, Cardiovascular & hematological disorders drug targets.

[75]  A. Vitin,et al.  A Randomized Clinical Trial Testing the Anti-Inflammatory Effects of Preemptive Inhaled Nitric Oxide in Human Liver Transplantation , 2014, PloS one.

[76]  M. Kavdia,et al.  Computational analysis of nitric oxide biotransport to red blood cell in the presence of free hemoglobin and NO donor. , 2014, Microvascular research.

[77]  E. Ongini,et al.  Nitric oxide (NO): an emerging target for the treatment of glaucoma. , 2014, Investigative ophthalmology & visual science.

[78]  P. Ridker.  LDL cholesterol: controversies and future therapeutic directions , 2014, The Lancet.

[79]  L. Forgan,et al.  The evolution of nitric oxide signalling in vertebrate blood vessels , 2014, Journal of Comparative Physiology B.

[80]  Megan P. Miller,et al.  Hemoglobin &agr;/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[81]  J. Detterich,et al.  Nitric oxide, vasodilation and the red blood cell. , 2014, Biorheology.

[82]  B. Isakson,et al.  The myoendothelial junction: connections that deliver the message. , 2014, Physiology.

[83]  A. Hausladen,et al.  Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia , 2015, Proceedings of the National Academy of Sciences.

[84]  J. Tanus-Santos,et al.  Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension. , 2015, Free radical biology & medicine.

[85]  R. Waugh,et al.  Piezo1 regulates mechanotransductive release of ATP from human RBCs , 2015, Proceedings of the National Academy of Sciences.

[86]  D. Gorog,et al.  Endogenous Fibrinolysis: An Important Mediator of Thrombus Formation and Cardiovascular Risk. , 2015, Journal of the American College of Cardiology.

[87]  Yingzi Zhao,et al.  Vascular nitric oxide: Beyond eNOS. , 2015, Journal of pharmacological sciences.

[88]  M. Gladwin,et al.  Strategies to increase nitric oxide signalling in cardiovascular disease , 2015, Nature Reviews Drug Discovery.

[89]  C. Ellis,et al.  Role of erythrocyte‐released ATP in the regulation of microvascular oxygen supply in skeletal muscle , 2016, Acta physiologica.

[90]  D. Jaron,et al.  A mathematical model for the role of N2O3 in enhancing nitric oxide bioavailability following nitrite infusion. , 2016, Nitric oxide : biology and chemistry.

[91]  M. Telen,et al.  Sevuparin binds to multiple adhesive ligands and reduces sickle red blood cell‐induced vaso‐occlusion , 2016, British journal of haematology.

[92]  P. Buehler,et al.  Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. , 2016, American journal of respiratory and critical care medicine.

[93]  R. Patel,et al.  Compartmentalization Is Key in Limiting Nitric Oxide Scavenging by Cell-Free Hemoglobin. , 2016, American journal of respiratory and critical care medicine.

[94]  M. Gladwin.  How Red Blood Cells Process Nitric Oxide: Evidence for the Nitrite Hypothesis , 2017, Circulation.

[95]  N. Secher,et al.  Nitrite and S-Nitrosohemoglobin Exchange Across the Human Cerebral and Femoral CirculationClinical Perspective , 2017 .

[96]  M. Kelm,et al.  Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia , 2017, Antioxidants & redox signaling.

[97]  L. Marshall,et al.  Paroxysmal nocturnal haemoglobinuria , 2017, Nature Reviews Disease Primers.

[98]  H. S. Warren,et al.  Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. , 2017, American journal of physiology. Heart and circulatory physiology.

[99]  J. Balligand,et al.  Nitric oxide signalling in cardiovascular health and disease , 2018, Nature Reviews Cardiology.

[100]  J. Stamler,et al.  Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle. , 2020, Circulation research.

[101]  Mark T Gladwin,et al.  Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation , 2019, Physiological reviews.

[102]  P. Kameritsch,et al.  Molecular regulation of myoendothelial gap junctions. , 2019, Current opinion in pharmacology.