Human Tau in an Ultradian Light-Dark Cycle

Multiple experimental approaches have been used to assess the free-running period, or “tau,” of humans. One approach has been to study circadian rhythms in free-running blind humans. For example, Sack et al. (1992) measured the plasma melatonin rhythm in 11 free-running blind people and reported an average tau of 24.55 h.

[1]  Jürgen Aschoff,et al.  The Circadian System of Man , 1979 .

[2]  D. Dawson,et al.  When the human circadian system is caught napping: evidence for endogenous rhythms close to 24 hours. , 1993, Sleep.

[3]  Claude Gronfier,et al.  Intrinsic Period and Light Intensity Determine the Phase Relationship between Melatonin and Sleep in Humans , 2005, Journal of biological rhythms.

[4]  Kenneth P. Wright,et al.  Entrainment of the Human Circadian System by Light , 2005, Journal of biological rhythms.

[5]  C. Eastman,et al.  How to Trick Mother Nature into Letting You Fly Around or Stay Up All Night , 2005, Journal of biological rhythms.

[6]  A. Lewy,et al.  Circadian rhythm abnormalities in totally blind people: incidence and clinical significance. , 1992, The Journal of clinical endocrinology and metabolism.

[7]  R. Wever The Circadian System of Man , 1979, Topics in Environmental Physiology and Medicine.

[8]  Wever Ra Characteristics of circadian rhythms in human functions. , 1986 .

[9]  R. Wever Basic Principles of Human Circadian Rhythms , 1992 .

[10]  Serge Daan,et al.  A functional analysis of circadian pacemakers in nocturnal rodents , 1976, Journal of comparative physiology.

[11]  R. H. van den Hoofdakker,et al.  Endogenous and exogenous components in the circadian variation of core body temperature in humans , 1997, Journal of sleep research.

[12]  R. Kronauer,et al.  Stability, precision, and near-24-hour period of the human circadian pacemaker. , 1999, Science.

[13]  D. Kripke,et al.  Circadian Phase in Adults of Contrasting Ages , 2005, Chronobiology international.

[14]  C. Eastman,et al.  A three pulse phase response curve to three milligrams of melatonin in humans , 2008, The Journal of physiology.

[15]  R. Wever Characteristics of circadian rhythms in human functions. , 1986, Journal of neural transmission. Supplementum.

[16]  B. Middleton,et al.  Complex Effects of Melatonin on Human Circadian Rhythms in Constant Dim Light , 1997, Journal of biological rhythms.

[17]  B M Stone,et al.  Human circadian rhythms in constant dim light (8 lux) with knowledge of clock time , 1996, Journal of sleep research.

[18]  D. Dawson,et al.  Salivary Melatonin as a Circadian Phase Marker: Validation and Comparison to Plasma Melatonin , 1997, Journal of biological rhythms.