The correlation of photometric signals derived from in vivo red blood cell flow in microvessels.

Abstract Photometric signals generated by projecting the in vivo image of microvessels of cat omentum onto two photodetectors aligned in the direction of blood flow were cross-correlated as a function of time delay and progressively greater detector spacing. It was found that the degree of correlation decreases as a function of increasing detector separation, in an approximate exponential fashion, until correlation is no longer discernible. The persistence of downstream correlation is inversely proportional to blood velocity and vessel diameters when these are greater than 30 μm and is directly proportional to velocity and diameter in smaller vessels. These results were related to a “correlation length” analogous to the mixed length theory for turbulent flows. It is proposed that a similarly defined parameter be established for blood flow in the microvascular system, and utilized to compare flowing blood in normal and abnormal conditions.

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