Pro‐inflammatory cytokines are raised in extrahepatic portal venous obstruction, with minimal hepatic encephalopathy

Background and Aims:  Minimal hepatic encephalopathy (MHE) and hyperammonemia are seen in patients with extrahepatic portal venous obstruction (EHPVO). Inflammation has been shown to play an important role in the pathogenesis of hepatic encephalopathy in cirrhotics. This study assessed serum pro‐inflammatory cytokines and their correlation with hyperammonemia, 1H‐magnetic resonance (MR) spectroscopy‐derived brain glutamine, and diffusion tensor imaging (DTI)‐derived metrics in patients with EPHVO, with and without MHE.

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