The vitamin K debacle and infants with cholestatic liver disease
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Editor,—We write in support of Tripp and McNinch’s paper1 recommending daily oral administration of 25 μg phytomenadione to all breast fed infants up to the age of six months. However, we remain concerned that high risk infants with cholestatic jaundice (up to 1 in 500 births2) are still liable to develop bleeding secondary to vitamin K deficiency.
An audit of all infants younger than 3 months admitted between 1 …
[1] J. Tripp,et al. The vitamin K debacle: cut the Gordian knot but first do no harm , 1998, Archives of disease in childhood.
[2] D. Kelly,et al. Population screening for neonatal liver disease: a feasibility study. , 1998, Journal of pediatric gastroenterology and nutrition.
[3] G. A. Mackinlay. Jaundice persisting beyond 14 days after birth. , 1993, BMJ.
[4] J. Golding,et al. Intramuscular vitamin K and childhood cancer , 1992 .