Abstract 2, 3-Butanediol is a very promising chemical due to its several applications and may be produced by microbial production. The recovery of 2, 3-Butanediol from the fermentation broth is yet a challenge due to its low concentration. Moreover, a broader point of view is also necessary since current needs require a process with low environmental impact and high inherent safety. In this work, the inherent risk will be approached at early-stages at the same time that economic and environmental issues. The aim of this paper is to synthesis, design and optimize some alternatives to purify 2,3-Butanediol based on distillation, those alternatives are synthesized in such way that is obtained as results thermally coupled, thermodynamically equivalent and intensified sequences. The alternatives were designed and optimized considering three objective functions: the total annual cost as an economic index, the eco-indicator 99 as an environmental index, and the inherent risk of the process (analyzed as individual risk). In general terms, the intensified alternative presented 15 % reduction of the TAC and 14% of the environmental impact. Moreover, the same alternative presented the lowest inherent risk with a reduction of about 50% in comparison with the reference alternative.
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