Demonstration of Mycoplasma hyorhinis as a Possible Primary Pathogen for Porcine Otitis Media

A study of the pathology of the ear was performed on 479 pigs ranging in age from 1 day to 1 year. Histologically, 364 (76.0%) of 479 pigs were affected with otitis. Eustachitis was the most common and preceded an inflammation of other sites of the ear, and an acute eustachitis occurred from as early as 1 week of life. Immunohistochemical examination of frozen cryostat sections revealed Mycoplasma hyorhinis (Mhr) antigens on the luminal surface of the eustachian epithelia in 14 (50.0%) of 28 piglets examined. All the pigs positive for Mhr had an acute eustachitis. Ultrastructural examination on the auditory tubes with positive immunostaining disclosed many mycoplasmas among the cilia. Mhr was isolated from the auditory tubes and tympanic cavities of 19 (67.9%) and 16 (57.1%) of 28 piglets examined, respectively. Porcine otitis media may be caused primarily by Mhr infection in the auditory tube.

[1]  学 尾形,et al.  Mycoplasma hyosynoviae , 1982, CABI Compendium.

[2]  M. Stenbeck,et al.  Respiratory system. , 1995, Acta oncologica.

[3]  D. Dungworth,et al.  The Respiratory System , 1993, Pathology of Domestic Animals.

[4]  T. Umemura,et al.  Detection of Mycoplasma hyorhinis in porcine eustachitis. , 1993, The Journal of veterinary medical science.

[5]  Y. Sakaguchi,et al.  A Pathologic and Bacteriologic Study on Otitis Media in Swine , 1992, Veterinary pathology.

[6]  G. Pearson,et al.  Inflammatory middle ear disease of the dog: the pathology of otitis media , 1991, Veterinary Record.

[7]  R. Boot,et al.  Otitis media in guineapigs: pathology and bacteriology , 1986 .

[8]  学 尾形,et al.  Mycoplasma hyopneumoniae の抗生物質感受性 , 1986 .

[9]  K. Yamamoto,et al.  In vitro susceptibility of Mycoplasma hyopneumoniae to antibiotics. , 1986, Nihon juigaku zasshi. The Japanese journal of veterinary science.

[10]  R. Boot,et al.  Otitis media in guinea pigs: pathology and bacteriology. , 1986, Laboratory Animals. Journal of the Laboratory Animal Science Association.

[11]  J. Weibel,et al.  Cause and pathogenesis of middle ear infection in young feedlot cattle. , 1983, Journal of the American Veterinary Medical Association.

[12]  S. Razin,et al.  Methods in mycoplasmology , 1983 .

[13]  S. Sorokin,et al.  The Respiratory System , 1983 .

[14]  J. Weibel,et al.  Middle ear infection in feedlot lambs. , 1982, Journal of the American Veterinary Medical Association.

[15]  M. Tajima,et al.  Interaction of Mycoplasma hyopneumoniae with the porcine respiratory epithelium as observed by electron microscopy , 1982, Infection and immunity.

[16]  J. Pukander,et al.  Incidence of acute otitis media. , 1982, Acta oto-laryngologica.

[17]  K. Yamamoto,et al.  Selective isolation of Mycoplasma hyosynoviae by anaerobic cultivation. , 1982, Nihon juigaku zasshi. The Japanese journal of veterinary science.

[18]  Olson Ld.  Gross and microscopic lesions of middle and inner ear infections in swine. , 1981 .

[19]  D. Roberts,et al.  The etiology of bullous myringitis and the role of mycoplasmas in ear disease: a review. , 1980, Pediatrics.

[20]  Orning Ap,et al.  Isolation of Mycoplasma arginini from swine and from a swine waste disposal system. , 1978 .

[21]  M. Barile,et al.  Isolation of Mycoplasma arginini from swine and from a swine waste disposal system. , 1978, American Journal of Veterinary Research.

[22]  Mebus Ca,et al.  Scanning electron microscopy of trachea and bronchi from gnotobiotic pigs inoculated with Mycoplasma hyopneumoniae. , 1977 .

[23]  Flatt Re,et al.  Suppurative otitis media in the rabbit: prevalence, pathology, and microbiology. , 1977 .

[24]  D. Deyoung,et al.  Suppurative otitis media in the rabbit: prevalence, pathology, and microbiology. , 1977, Laboratory animal science.

[25]  C. Mebus,et al.  Scanning electron microscopy of trachea and bronchi from gnotobiotic pigs inoculated with Mycoplasma hyopneumoniae. , 1977, American journal of veterinary research.

[26]  A. Baskerville,et al.  Ultrastructural changes in experimental enzootic pneumonia of pigs. , 1973, Research in veterinary science.

[27]  C. Mebus,et al.  Pathogenesis of mycoplasmal pneumonia in swine. , 1972, American journal of veterinary research.

[28]  M. Góis,et al.  Production of pneumonia after intransal inoculation of gnotobiotic piglets with three strains of Mycoplasma hyorhinis. , 1971, Journal of comparative pathology.

[29]  W. Clyde,et al.  Mycoplasma pneumoniae pneumonia. , 1971, Military medicine.

[30]  W. P. Glezen,et al.  Mycoplasma pneumoniae disease: clinical spectrum, pathophysiology, epidemiology, and control. , 1971, The Journal of infectious diseases.

[31]  S. Mawson.  Diseases of the Ear , 1911, Glasgow Medical Journal.