Artomandin, a new xanthone from Artocarpus kemando (Moraceae)

A new furanodihydrobenzoxanthone, artomandin (1), together with three other flavonoid derivatives, artoindonesianin C (2), artonol B (3), and artochamin A (4), as well as β-sitosterol (5) were isolated from the stem bark of Artocarpus kemando. The structures of these compounds were determined on the basis of spectral evidence. All of these compounds displayed inhibition effects to a very susceptible degree in cancer cell line tests. Compound 1 also exhibited significant antioxidant capacity in the free radical 1,1-diphenyl-2-picrylhydrazyl tests.

[1]  Y. Fujimoto,et al.  Chemical constituents of the fruits of Artocarpus altilis , 2008 .

[2]  U. Jayasinghe,et al.  Four new prenylated flavonoids and xanthones from the root bark of Artocarpus nobilis. , 2008, Fitoterapia.

[3]  Xiaoxiang Zheng,et al.  Geranyl flavonoids from the leaves of Artocarpus altilis. , 2007, Phytochemistry.

[4]  G. Amin,et al.  Chemical Constituents of Dichloromethane Extract of Cultivated Satureja khuzistanica , 2006, Evidence-based complementary and alternative medicine : eCAM.

[5]  M. Öztürk,et al.  Antioxidant abietane diterpenoids from Salvia barrelieri , 2007 .

[6]  E. Ghisalberti,et al.  Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae) , 2006, Journal of natural medicines.

[7]  C. Hung,et al.  Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. , 2005, Journal of agricultural and food chemistry.

[8]  G. Ee,et al.  Structure-Activity Relationship of Xanthones from Mesua daphnifolia and Garcinia nitida towards Human Estrogen Receptor Nagative Breast Cancer Cell Line , 2005 .

[9]  Han-Dong Sun,et al.  New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama. , 2004, Journal of natural products.

[10]  H. Sakagami,et al.  Antinephritis and radical scavenging activity of prenylflavonoids. , 2003, Fitoterapia.

[11]  G. Cordell,et al.  Bioactive prenylated flavonoids from the stem bark ofartocarpus kemando , 2003, Archives of pharmacal research.

[12]  H. Takayama,et al.  Artoindonesianin C, a new xanthone derivative from Artocarpus teysmanii. , 2000, Journal of natural products.

[13]  H. Cidade,et al.  Further prenylflavonoids from Artocarpus elasticus , 1998 .

[14]  D. Peterson,et al.  Mechanism of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction , 1997, Journal of neurochemistry.

[15]  T. Nomura,et al.  Artonols A, B, C, D, and E, five new isoprenylated phenols from the bark of Artocarpus communis forst. , 1997 .