Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease

In this work, we imaged the retina of wild-type and triple-transgenic mice model of Alzheimer’s disease (AD) (3xTg-AD), at the ages of one and two months, by optical coherence tomography. Texture analysis of calculated fundus images, for the six most anterior layers of the retina, present widespread differences between groups, demonstrating that retinal changes in the animal model of AD are notorious across the neuroretina. These results and the consistency of data pave the way for the identification of texture biomarkers of disease onset and progression with potential application to the human retina.

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