Regulation of cellular iron metabolism
暂无分享,去创建一个
[1] T. Rouault,et al. Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins , 2009, Metabolic Brain Disease.
[2] C. Lok,et al. The transferrin receptor: role in health and disease. , 1999, The international journal of biochemistry & cell biology.
[3] N. Grishin,et al. An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis , 2009, Science.
[4] R. Cousins,et al. Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells , 2006, Proceedings of the National Academy of Sciences.
[5] R. Fleming. Iron and inflammation: cross-talk between pathways regulating hepcidin , 2008, Journal of Molecular Medicine.
[6] D. Richardson,et al. Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1 , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[7] A. Biederbick,et al. Iron-Dependent Degradation of Apo-IRP1 by the Ubiquitin-Proteasome Pathway , 2007, Molecular and Cellular Biology.
[8] D. Brenner,et al. Hepatitis C virus–induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity , 2008, Hepatology.
[9] M. Knutson,et al. ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin* , 2010, The Journal of Biological Chemistry.
[10] Wei Li,et al. Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit. , 2010, Antioxidants & redox signaling.
[11] M. Kennedy,et al. Evidence That Phosphorylation of Iron Regulatory Protein 1 at Serine 138 Destabilizes the [4Fe-4S] Cluster in Cytosolic Aconitase by Enhancing 4Fe-3Fe Cycling* , 2009, Journal of Biological Chemistry.
[12] C. Camaschella,et al. Pathogenesis of hyperferritinemia cataract syndrome. , 2002, Blood cells, molecules & diseases.
[13] M. Koenig,et al. Friedreich ataxia: the oxidative stress paradox. , 2005, Human molecular genetics.
[14] K. Pantopoulos,et al. Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity , 2008, BMC Molecular Biology.
[15] T. Grune,et al. Oxidation-induced ferritin turnover in microglial cells: role of proteasome. , 2005, Free radical biology & medicine.
[16] Dimitrios Galaris,et al. Oxidative stress and iron homeostasis: mechanistic and health aspects. , 2008, Critical reviews in clinical laboratory sciences.
[17] J. Guest,et al. Direct evidence for mRNA binding and post-transcriptional regulation by Escherichia coli aconitases. , 1999, Microbiology.
[18] R. Lill,et al. Human Nbp35 Is Essential for both Cytosolic Iron-Sulfur Protein Assembly and Iron Homeostasis , 2008, Molecular and Cellular Biology.
[19] F. Carvalho,et al. ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C/EBPalpha Activity , 2009, PloS one.
[20] A. Donovan,et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. , 2005, Cell metabolism.
[21] M. Cazzola,et al. Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. , 2003, Blood.
[22] J. Andersen,et al. Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease , 2009, Brain Research.
[23] Jean Mosser,et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. , 2008, Blood.
[24] Yin Xia,et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism , 2009, Nature Genetics.
[25] C. Fillebeen,et al. Redox control of iron regulatory proteins , 2002, Redox report : communications in free radical research.
[26] C. Lok,et al. Identification of an Erythroid Active Element in the Transferrin Receptor Gene* , 2000, The Journal of Biological Chemistry.
[27] D. Kell. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases , 2008, BMC Medical Genomics.
[28] P. Ponka. Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. , 1997, Blood.
[29] G. Minotti,et al. Iron regulatory proteins: from molecular mechanisms to drug development. , 2010, Antioxidants & redox signaling.
[30] G. Musci,et al. Ferroportin‐mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome , 2006, The EMBO journal.
[31] M. Roth,et al. Lack of the bone morphogenetic protein BMP6 induces massive iron overload , 2009, Nature Genetics.
[32] W. Koppenol. The centennial of the Fenton reaction. , 1993, Free radical biology & medicine.
[33] P. Aisen,et al. Chemistry and biology of eukaryotic iron metabolism. , 2001, The international journal of biochemistry & cell biology.
[34] T. Rouault. The role of iron regulatory proteins in mammalian iron homeostasis and disease , 2006, Nature chemical biology.
[35] N. Andrews,et al. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. , 2005, The Journal of clinical investigation.
[36] Matthias W. Hentze,et al. Two to Tango: Regulation of Mammalian Iron Metabolism , 2010, Cell.
[37] Paolo Arosio,et al. Ferritins: a family of molecules for iron storage, antioxidation and more. , 2009, Biochimica et biophysica acta.
[38] A. Brownlie,et al. Mitoferrin is essential for erythroid iron assimilation , 2006, Nature.
[39] R. Lill,et al. The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol. , 2007, Nature chemical biology.
[40] A. Bosserhoff,et al. Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors , 2009, PloS one.
[41] Xiaoling Xu,et al. A Role of Smad4 in Iron Metabolism through the Positive Regulation of Hepcidin Expression , 2022 .
[42] H. Elsässer,et al. Role of Human Mitochondrial Nfs1 in Cytosolic Iron-Sulfur Protein Biogenesis and Iron Regulation , 2006, Molecular and Cellular Biology.
[43] F. Torti,et al. Regulation of ferritin genes and protein. , 2002, Blood.
[44] B. Paw,et al. Deficiency of glutaredoxin 5 reveals Fe–S clusters are required for vertebrate haem synthesis , 2005, Nature.
[45] Shizuo Akira,et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron , 2004, Nature.
[46] Michael R. Green,et al. A Cell-Surface Receptor for Lipocalin 24p3 Selectively Mediates Apoptosis and Iron Uptake , 2005, Cell.
[47] E. Rankin,et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. , 2007, The Journal of clinical investigation.
[48] T. Rouault,et al. Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. , 2006, Cell metabolism.
[49] R. Johnson,et al. Acute postnatal ablation of Hif-2α results in anemia , 2007, Proceedings of the National Academy of Sciences.
[50] B. Andriopoulos,et al. Sodium Nitroprusside Promotes IRP2 Degradation via an Increase in Intracellular Iron and in the Absence of S Nitrosylation at C178 , 2006, Molecular and Cellular Biology.
[51] A. Vasanthakumar,et al. Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[52] Subramanian Rajagopalan,et al. Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo A Novel Therapy for Parkinson's Disease , 2003, Neuron.
[53] Elizabeth C. Theil,et al. Structure of Dual Function Iron Regulatory Protein 1 Complexed with Ferritin IRE-RNA , 2006, Science.
[54] T. Stemmler,et al. A Cytosolic Iron Chaperone That Delivers Iron to Ferritin , 2008, Science.
[55] S. Mueller,et al. Sustained Hydrogen Peroxide Induces Iron Uptake by Transferrin Receptor-1 Independent of the Iron Regulatory Protein/Iron-responsive Element Network* , 2007, Journal of Biological Chemistry.
[56] J. Drapier,et al. RNA Silencing of Mitochondrial m-Nfs1 Reduces Fe-S Enzyme Activity Both in Mitochondria and Cytosol of Mammalian Cells* , 2006, Journal of Biological Chemistry.
[57] D. Dean,et al. Structure, function, and formation of biological iron-sulfur clusters. , 2005, Annual review of biochemistry.
[58] M. Hentze,et al. Iron regulatory proteins secure mitochondrial iron sufficiency and function. , 2010, Cell metabolism.
[59] E. Meyron-Holtz,et al. Mammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo , 2004, Science.
[60] M. Hentze,et al. In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation , 2009, Journal of Molecular Medicine.
[61] J. J. Sharp,et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells , 2005, Nature Genetics.
[62] W. Seaman,et al. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1 , 2010, Proceedings of the National Academy of Sciences.
[63] S. Ryter,et al. The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. , 2000, Free radical biology & medicine.
[64] Hermann-Josef Gröne,et al. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. , 2008, Cell metabolism.
[65] N. Andrews,et al. ASH 50th Anniversary Reviews (34 articles) , 2022 .
[66] S. J. Romney,et al. Cysteine Oxidation Regulates the RNA-Binding Activity of Iron Regulatory Protein 2 , 2009, Molecular and Cellular Biology.
[67] Elizabeth C. Theil,et al. Localized Unfolding at the Junction of Three Ferritin Subunits , 1998, The Journal of Biological Chemistry.
[68] M. Hentze,et al. IRP1-independent alterations of cardiac iron metabolism in doxorubicin-treated mice , 2006, Journal of Molecular Medicine.
[69] H. Elsässer,et al. Iron-sulfur protein maturation in human cells: evidence for a function of frataxin. , 2004, Human molecular genetics.
[70] D. Song,et al. A Role for IOP1 in Mammalian Cytosolic Iron-Sulfur Protein Biogenesis* , 2008, Journal of Biological Chemistry.
[71] B. Andriopoulos,et al. Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo , 2009, Proceedings of the National Academy of Sciences.
[72] W. Breuer,et al. The importance of non-transferrin bound iron in disorders of iron metabolism. , 2000, Transfusion science.
[73] Xudong Huang,et al. Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1*♦ , 2010, The Journal of Biological Chemistry.
[74] R. Eisenstein,et al. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. , 2006, Biochimica et biophysica acta.
[75] S. Srai,et al. Activated macrophages induce hepcidin expression in HuH7 hepatoma cells , 2009, Haematologica.
[76] S. Moestrup,et al. The endocytic receptor megalin binds the iron transporting neutrophil‐gelatinase‐associated lipocalin with high affinity and mediates its cellular uptake , 2005, FEBS letters.
[77] Manuela M. Santos,et al. Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis? , 2009, Hepatology.
[78] M. Hentze,et al. Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. , 2009, Blood.
[79] D. Gilot,et al. C/EBPα Regulates Hepatic Transcription of Hepcidin, an Antimicrobial Peptide and Regulator of Iron Metabolism , 2002, The Journal of Biological Chemistry.
[80] N. Andrews,et al. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[81] T. Ganz,et al. Suppression of hepcidin during anemia requires erythropoietic activity. , 2006, Blood.
[82] N. Andrews,et al. Disorders of iron metabolism. , 1999, The New England journal of medicine.
[83] T. Rouault,et al. Roles of the Mammalian Cytosolic Cysteine Desulfurase, ISCS, and Scaffold Protein, ISCU, in Iron-Sulfur Cluster Assembly* , 2006, Journal of Biological Chemistry.
[84] T. Rouault,et al. Metabolic regulation of citrate and iron by aconitases: role of iron–sulfur cluster biogenesis , 2007, BioMetals.
[85] T. Samuelsson,et al. Evolution of the iron-responsive element. , 2007, RNA.
[86] H. Beug,et al. Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis. , 2006, Blood.
[87] M. L. Rawlins,et al. Oxygen and Iron Regulation of Iron Regulatory Protein 2* , 2003, Journal of Biological Chemistry.
[88] K. Pantopoulos,et al. Redox control of iron regulatory protein 2 stability , 2011, FEBS letters.
[89] S. Wing,et al. S-Nitrosylation of IRP2 Regulates Its Stability via the Ubiquitin-Proteasome Pathway , 2004, Molecular and Cellular Biology.
[90] D. Templeton,et al. Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state. , 2010, The Biochemical journal.
[91] K. Pantopoulos,et al. Nitric Oxide Inhibits the Degradation of IRP2 , 2005, Molecular and Cellular Biology.
[92] T. Rouault,et al. Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease† , 2010, Biochemistry.
[93] T. Rouault,et al. Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. , 2009, Human molecular genetics.
[94] L. Kühn,et al. Intestinal ferritin H is required for an accurate control of iron absorption. , 2010, Cell metabolism.
[95] M. Hentze,et al. Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). , 2005, Blood.
[96] S. Moestrup,et al. Identification of the haemoglobin scavenger receptor , 2001, Nature.
[97] C. Beaumont,et al. Early Embryonic Lethality of H Ferritin Gene Deletion in Mice* , 2000, The Journal of Biological Chemistry.
[98] Katrin Beyer,et al. Systematic genomic screening and analysis of mRNA in untranslated regions and mRNA precursors: combining experimental and computational approaches , 1998, Bioinform..
[99] T. Golub,et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. , 2008, Molecular cell.
[100] C. Ouzounis,et al. Tumorigenic Properties of Iron Regulatory Protein 2 (IRP2) Mediated by Its Specific 73-Amino Acids Insert , 2010, PloS one.
[101] V. Nizet,et al. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. , 2006, Blood.
[102] R. Kaufman,et al. ER Stress Controls Iron Metabolism Through Induction of Hepcidin , 2009, Science.
[103] R. Lill,et al. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. , 2010, Nature chemical biology.
[104] T. Rouault,et al. Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. , 2006, Blood cells, molecules & diseases.
[105] H. Erdjument-Bromage,et al. An iron delivery pathway mediated by a lipocalin. , 2002, Molecular cell.
[106] S. Abboud,et al. A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism* , 2000, The Journal of Biological Chemistry.
[107] J. Balk,et al. The Essential WD40 Protein Cia1 Is Involved in a Late Step of Cytosolic and Nuclear Iron-Sulfur Protein Assembly , 2005, Molecular and Cellular Biology.
[108] C. Masters,et al. Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease , 2010, Cell.
[109] Kazuhiro Iwai,et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice , 2001, Nature Genetics.
[110] David N. Powers,et al. Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase , 2009, Science.
[111] L. Bockenstedt,et al. Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi. , 2009, Blood.
[112] Nancy Andrews,et al. Transferrin receptor is necessary for development of erythrocytes and the nervous system , 1999, Nature Genetics.
[113] F. Petrat,et al. The Chelatable Iron Pool in Living Cells: A Methodically Defined Quantity , 2002, Biological chemistry.
[114] S. Vaulont,et al. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes , 2009, Haematologica.
[115] R J Simpson,et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. , 2000, Molecular cell.
[116] N. Andrews,et al. The molecular defect in hypotransferrinemic mice. , 2000, Blood.
[117] J. Abkowitz,et al. A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis , 2008, Science.
[118] E. Bourdon,et al. The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2. , 2003, Blood cells, molecules & diseases.
[119] K. Pantopoulos,et al. Modulation of Cellular Iron Metabolism by Hydrogen Peroxide , 2001, The Journal of Biological Chemistry.
[120] R. Crystal. Managed care for viruses , 1997, Nature Medicine.
[121] Simone Sanna-Cherchi,et al. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. , 2009, Developmental cell.
[122] K. Pantopoulos,et al. Conditional Derepression of Ferritin Synthesis in Cells Expressing a Constitutive IRP1 Mutant , 2002, Molecular and Cellular Biology.
[123] D. Richardson,et al. Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol , 2010, Proceedings of the National Academy of Sciences.
[124] M. Hentze,et al. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. , 2010, Blood.
[125] Mayka Sanchez,et al. Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency , 2007, Nature Structural &Molecular Biology.
[126] F. Daldal,et al. Dre2, a Conserved Eukaryotic Fe/S Cluster Protein, Functions in Cytosolic Fe/S Protein Biogenesis , 2008, Molecular and Cellular Biology.
[127] C. Bougault,et al. Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein. , 2007, The Biochemical journal.
[128] J. Jelinek,et al. Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice , 2004, Development.
[129] C. Fillebeen,et al. IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities. , 2005, The Biochemical journal.
[130] Jiri Petrak,et al. A novel iron responsive element in the 3'UTR of human MRCKalpha. , 2006, Biochemical and biophysical research communications.
[131] M. Hentze,et al. Iron-Mediated Degradation of IRP2, an Unexpected Pathway Involving a 2-Oxoglutarate-Dependent Oxygenase Activity , 2004, Molecular and Cellular Biology.
[132] Ian R. Drexler,et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. , 2005, The Journal of clinical investigation.
[133] Jerry Kaplan,et al. Regulation of iron acquisition and storage: consequences for iron-linked disorders , 2008, Nature Reviews Molecular Cell Biology.
[134] Maya Shvartsman,et al. Intracellular labile iron. , 2008, The international journal of biochemistry & cell biology.
[135] R. Strong,et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. , 2002, Molecular cell.
[136] Jerry Kaplan,et al. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. , 2009, Cell metabolism.
[137] L. Kühn,et al. Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage , 2009, Hepatology.
[138] Kou-Juey Wu,et al. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. , 1999, Science.
[139] W. Walden,et al. A novel eukaryotic factor for cytosolic Fe–S cluster assembly , 2003, The EMBO journal.
[140] Claudius Mueller,et al. Iron regulatory protein 2 is involved in brain copper homeostasis. , 2009, Journal of Alzheimer's disease : JAD.
[141] M. Muckenthaler,et al. Iron refractory iron deficiency anemia , 2013, Haematologica.
[142] R. Tanzi,et al. The 5′-untranslated region of Parkinson's disease α-synuclein messengerRNA contains a predicted iron responsive element , 2007, Molecular Psychiatry.
[143] E. Beutler,et al. Regulation of hepcidin and iron-overload disease. , 2009, Annual review of pathology.
[144] P. Højrup,et al. Identification of the receptor scavenging hemopexin-heme complexes. , 2005, Blood.
[145] S. Goh,et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin , 2007, Nature Medicine.
[146] S. Mueller,et al. Myeloperoxidase-derived Hypochlorous Acid Antagonizes the Oxidative Stress-mediated Activation of Iron Regulatory Protein 1* , 2003, Journal of Biological Chemistry.
[147] Michael R. Green,et al. A Mammalian Siderophore Synthesized by an Enzyme with a Bacterial Homolog Involved in Enterobactin Production , 2010, Cell.
[148] R. Lill. Function and biogenesis of iron–sulphur proteins , 2009, Nature.
[149] J. Tisdale,et al. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. , 2010, The Journal of clinical investigation.
[150] A. Norrby,et al. Comment to: Hepcidin: from discovery to differential diagnosis. Haematologica 2008; 93:90-7 , 2008, Haematologica.
[151] M. Gassmann,et al. Hypoxic up-regulation of erythroid 5-aminolevulinate synthase. , 2003, Blood.
[152] S. J. Romney,et al. Iron-independent Phosphorylation of Iron Regulatory Protein 2 Regulates Ferritin during the Cell Cycle* , 2008, Journal of Biological Chemistry.
[153] J. Kaplan,et al. Specific iron chelators determine the route of ferritin degradation. , 2009, Blood.
[154] Stephan Nussberger,et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter , 1997, Nature.
[155] J. Drapier,et al. Recycling of RNA Binding Iron Regulatory Protein 1 into an Aconitase after Nitric Oxide Removal Depends on Mitochondrial ATP* , 2002, The Journal of Biological Chemistry.
[156] K. Iwai,et al. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis , 2004, The EMBO journal.
[157] N. Andrews,et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene , 1997, Nature genetics.
[158] Jerry Kaplan,et al. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. , 2008, Cell metabolism.
[159] C. Beaumont,et al. H-ferritin subunit overexpression in erythroid cells reduces the oxidative stress response and induces multidrug resistance properties. , 1999, Blood.
[160] A. Bosserhoff,et al. Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo. , 2010, Gastroenterology.
[161] T. Ganz,et al. The Role of Hepcidin in Iron Metabolism , 2009, Acta Haematologica.
[162] Benjamin L Ebert,et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. , 2010, Cancer research.
[163] Marta A. Uzarska,et al. Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. , 2010, Cell metabolism.
[164] B. Jortner,et al. Severity of Neurodegeneration Correlates with Compromise of Iron Metabolism in Mice with Iron Regulatory Protein Deficiencies , 2004, Annals of the New York Academy of Sciences.
[165] Peter Bengert,et al. Iron Regulation and the Cell Cycle , 2006, Journal of Biological Chemistry.
[166] Y. T. Lee,et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. , 2009, Blood.
[167] T. Rouault,et al. A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. , 2009, Cell metabolism.
[168] J. Connor,et al. Subcellular localization of iron regulatory proteins to Golgi and ER membranes , 2005, Journal of Cell Science.
[169] C. Fillebeen,et al. A Phosphomimetic Mutation at Ser-138 Renders Iron Regulatory Protein 1 Sensitive to Iron-Dependent Degradation , 2003, Molecular and Cellular Biology.
[170] Jong-Wan Park,et al. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. , 2007, Biochemical and biophysical research communications.
[171] I. Hamza,et al. Trafficking of heme and porphyrins in metazoa. , 2009, Chemical reviews.
[172] J. Gollan,et al. Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression* , 2006, Journal of Biological Chemistry.
[173] P. Ponka,et al. Ferritin does not donate its iron for haem synthesis in macrophages. , 2010, The Biochemical journal.
[174] Fatima Mechta-Grigoriou,et al. JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress , 2004, Cell.
[175] C. Beaumont,et al. Function and regulation of transferrin and ferritin. , 1998, Seminars in hematology.
[176] K. Yeh,et al. Iron feeding induces ferroportin 1 and hephaestin migration and interaction in rat duodenal epithelium. , 2009, American journal of physiology. Gastrointestinal and liver physiology.
[177] M. Hentze,et al. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[178] C. Epstein,et al. Iron‐responsive degradation of iron‐regulatory protein 1 does not require the Fe–S cluster , 2006, The EMBO journal.
[179] A. Dautry‐Varsat,et al. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[180] F. Brodsky,et al. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis , 2005, The Journal of experimental medicine.
[181] James B. Mitchell,et al. Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice , 2008, Proceedings of the National Academy of Sciences.
[182] M. Hentze,et al. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. , 2008, Annual review of nutrition.
[183] A. Sonenshein,et al. Bacillus subtilis aconitase is an RNA-binding protein. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[184] P. Arosio,et al. Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation. , 2005, Best practice & research. Clinical haematology.
[185] P. Artymiuk,et al. The aconitase family: three structural variations on a common theme. , 1997, Trends in biochemical sciences.
[186] P. Arosio,et al. Mitochondrial ferritin. , 2004, International Journal of Biochemistry and Cell Biology.
[187] J. Kutok,et al. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. , 2006, Human molecular genetics.
[188] R. Bruick,et al. Maintaining Mammalian Iron and Oxygen Homeostasis , 2009, Annals of the New York Academy of Sciences.
[189] R. Hider. Nature of nontransferrin‐bound iron , 2002, European journal of clinical investigation.
[190] F. Petrat,et al. Assessment of Chelatable Mitochondrial Iron by Using Mitochondrion‐Selective Fluorescent Iron Indicators with Different Iron‐Binding Affinities , 2007, Chembiochem : a European journal of chemical biology.
[191] E. Meyron-Holtz,et al. Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. , 2005, Blood.
[192] F. Gonzalez,et al. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. , 2009, Cell metabolism.
[193] C. French,et al. Diversity and distribution of hemerythrin-like proteins in prokaryotes. , 2008, FEMS microbiology letters.
[194] J. Connor,et al. Iron, brain ageing and neurodegenerative disorders , 2004, Nature Reviews Neuroscience.
[195] C. Fillebeen,et al. Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts. , 2006, Carcinogenesis.
[196] G. Weiss,et al. Cytokine Mediated Regulation of Iron Transport in Human Monocytic Cells , 2003 .
[197] F. Thévenod,et al. Iron transport and the kidney. , 2009, Biochimica et biophysica acta.
[198] J. Dupuy,et al. Crystal structure of human iron regulatory protein 1 as cytosolic aconitase. , 2006, Structure.
[199] B. Paw,et al. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria , 2009, Proceedings of the National Academy of Sciences.
[200] B. Paw,et al. Regulation of Mitochondrial Iron Import through Differential Turnover of Mitoferrin 1 and Mitoferrin 2 , 2008, Molecular and Cellular Biology.
[201] H. Tsukamoto,et al. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. , 2009, Cell metabolism.
[202] M. Hentze,et al. Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse , 2006, Nature Genetics.
[203] S. David,et al. Glycosylphosphatidylinositol-anchored Ceruloplasmin Is Required for Iron Efflux from Cells in the Central Nervous System* , 2003, Journal of Biological Chemistry.