Insulin-injection-site reactions associated with type I latex allergy.

To the Editor: A 35-year-old woman with diabetes presented with pruritic, erythematous, urticated plaques at insulin-injection sites, persisting for up to 48 hours (Figure 1). Reactions were associated with the use of Humulin I and Humulin S (Lilly) injected with a prefilled cartridge pen and Human Monotard (Novo Nordisk) aspirated from a vial and injected with a latex-free Microfine syringe. The patient had positive skin-prick-test reactions to an aqueous powdered-latex-glove solution and commercial solutions ALK (960) Latex 100 and 10 HEP (Soluprick SQ). Skin-prick testing directly through an insulin-vial bung was also positive. We then compared injection of 10 U . . .